Differential inhibitor of Gβγ signaling to AKT and ERK derived from phosducin-like protein: Effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis

Journal of Biological Chemistry

Volumn 284, Issue 27, 2009, Pages 18334-18346

  Guzmán Hernández, María Luisa ^a   Vázquez Macías, Aleida ^a   Carretero Ortega, Jorge ^a   Hernández García, Ricardo ^a   García Regalado, Alejandro ^a   Hernández Negrete, Ivette ^a   Reyes Cruz, Guadalupe ^a   Gutkind, J Silvio ^b   Vázquez Prado, José ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; CELL MIGRATION; CO-IMMUNOPRECIPITATION EXPERIMENTS; GLYCOGEN SYNTHASE KINASE-3; HEPATOCYTE GROWTH FACTOR; HETERODIMER; IN-VITRO; MOLECULAR DETERMINANTS; OVER-EXPRESSION; PHOSPHOINOSITIDE 3-KINASE; PLASMA MEMBRANES; SIGNALING PATHWAYS; SPHINGOSINE 1 PHOSPHATES; TUBULOGENESIS;

BLOOD VESSEL PROSTHESES; CELL MEMBRANES; CYTOLOGY; PHOSPHORYLATION; SELF ASSEMBLY; SIGNALING;

ENDOTHELIAL CELLS;

GBETA,GAMMA PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSDUCIN LIKE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHOPROTEIN; PROTEIN KINASE B; SCATTER FACTOR; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG; CARRIER PROTEIN; DRUG DERIVATIVE; G PROTEIN BETA GAMMA; G-PROTEIN BETA GAMMA; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; LYSOPHOSPHOLIPID; NERVE PROTEIN; PDCL PROTEIN, HUMAN; PERTUSSIS TOXIN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANGIOGENESIS; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; AORTA; CELL LINE; CELL MOTION; CHEMISTRY; CYTOLOGY; DIMERIZATION; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; IN VITRO STUDY; KIDNEY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; SWINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; AORTA; CARRIER PROTEINS; CELL LINE; CELL MOVEMENT; DIMERIZATION; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; KIDNEY; LYSOPHOSPHOLIPIDS; MAP KINASE SIGNALING SYSTEM; MUTAGENESIS, SITE-DIRECTED; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; SPHINGOSINE; SWINE; TRANSFECTION;

EID: 67650546983     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.008839     Document Type: Article

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