Phosducin-like proteins in Dictyostelium discoideum: Implications for the phosducin family of proteins

EMBO Journal

Volumn 22, Issue 19, 2003, Pages 5047-5057

  Blaauw, Mieke ^a   Knol, Jaco C ^a   Kortholt, Arjan ^a   Roelofs, Jeroen ^a,b   Ruchira, ^a   Postma, Marten ^a   Visser, Antonie J W G ^a   Van Haastert, Peter J M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chaperone; Dictyostelium; G protein; Phosducin; Signal transduction

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSDUCIN; PHOSDUCIN LIKE PROTEIN; PROTOZOAL PROTEIN; TRANSDUCIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; DICTYOSTELIUM DISCOIDEUM; EUKARYOTIC CELL; METAZOON; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL CELL; PHYLOGENY; PLANT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; DICTYOSTELIUM; GENES, REPORTER; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NERVE TISSUE PROTEINS; PHYLOGENY; SEQUENCE ANALYSIS, PROTEIN;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; EUKARYOTA; METAZOA; PROTOZOA;

EID: 0141642022     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg508     Document Type: Article

References (40)

1. Barhite, S., Thibault, C. and Miles, M.F. (1998) Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1. Biochim. Biophys. Acta, 1402, 95-101.
2. Bauer, P.H., Muller, S., Puzicha, M., Pippig, S., Obermaier, B., Helmreich, E.J. and Lohse, M.J. (1992) Phosducin is a protein kinase A-regulated G-protein regulator. Nature, 358, 73-76.
3. Bluml, K., Schnepp, W., Schroder, S., Beyermann, M., Macias, M., Oschkinat, H. and Lohse, M.J. (1997) A small region in phosducin inhibits G-protein βγ-subunit function. EMBO J., 16, 4908-4915.
4. Clapham, D.E. and Neer, E.J. (1997) G protein βγ subunits. Annu. Rev. Pharmacol. Toxicol., 37, 167-203.
5. Craft, C.M., Xu, J., Slepak, V.Z., Zhan-Poe, X., Zhu, X., Brown, B. and Lolley, R.N. (1998) PhLPs and PhLOPs in the phosducin family of G βγ binding proteins. Biochemistry, 37, 15758-15772.
6. Danner, S. and Lohse, M.J. (1996) Phosducin is a ubiquitous G-protein regulator. Proc. Natl Acad. Sci. USA, 93, 10145-10150.
7. Dohlman, H.G. (2002) G proteins and pheromone signaling. Annu. Rev. Physiol., 64, 129-152.
8. Felsenstein, J. (1996) Inferring phylogenies from protein sequences by parsimony, distance and likelihood methods. Methods Enzymol., 266, 418-427.
9. Firtel, R.A. and Chung, C.Y. (2000) The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients, Bioessays, 22, 603-615.
10. Flanary, P.L., DiBello, P.R., Estrada, P. and Dohlman, H.G. (2000) Functional analysis of Plp1 and Plp2, two homologues of phosducin in yeast. J. Biol. Chem., 275, 18462-18469.
11. Garcia-Higuera, I., Gaitatzes, C., Smith, T.F. and Neer, E.J. (1998) Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein β subunit and Sec13. J. Biol. Chem., 273, 9041-9049.
12. Gaudet, R., Bohm, A. and Sigler, P. B. (1996) Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell, 87, 577-588,
13. Hamm, H.E. (1998) The many faces of G protein signaling. J. Biol. Chem., 273, 669-672.
14. Janetopoulos, C., Jin, T. and Devreotes, P. (2001) Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science, 291, 2408-2411.
15. Kasahara, S., Wang, P. and Nuss, D.L. (2000) Identification of bdm-1, a gene involved in G protein β-subunit function and α-subunit accumulation. Proc. Natl Acad. Sci. USA, 97, 412-417.
16. Konijn, T.M. (1970) Microbiological assay of cyclic 3′,5′ -AMP. Experientia, 26, 367-369.
17. Kuwayama, H., Ishida, S. and Van Haastert, P.J.M. (1993) Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction. J. Cell Biol., 123, 1453-1462.
18. Lee, R.H., Fowler, A., McGinnis, J.F., Lolley, R.N. and Craft, C.M. (1990) Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells. J. Biol. Chem., 265, 15867-15873.
19. Lilly, P., Wu, L., Welker, D.L. and Devreotes, P.N. (1993) A G-protein β-subunit is essential for Dictyostelium development. Genes Dev., 7, 986-995.
20. Linskens, M.H., Grootenhuis, P.D., Blaauw, M., Huisman-de Winkel, B., Van Ravestein, A., Van Haastert, P.J. and Heikoop, J.C. (1999) Random mutagenesis and screening of complex glycoproteins: expression of human gonadotropins in Dictyostelium discoideum. FASEB J., 13, 639-645.
21. Loew, A., Ho, Y.K., Blundell, T. and Bax, B. (1998) Phosducin induces a structural change in transducin βγ. Structure, 6, 1007-1019.
22. Lopez, P., Yaman, R., Lopez-Fernandez, L.A., Vidal, F., Puel, D., Clertant, P., Cuzin, F. and Rassoulzadegan, M. (2003) A novel germ line-specific gene of the phosducin-like protein (PhLP) family. A meiotic function conserved from yeast to mice. J. Biol. Chem., 278, 1751-1757.
23. McLaughlin, J.N., Thulin, C.D., Hart, S.J., Resing, K.A., Ahn, N.G. and Willardson, B.M. (2002) Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. Proc. Natl Acad. Sci. USA, 99, 7962-7967.
24. Miles, M.F., Barhite, S., Sganga, M. and Elliott, M. (1993) Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl Acad. Sci. USA, 90, 10831-10835.
25. Muntz, K.H., Sternweis, P.C., Gilman, A.G. and Mumby, S.M. (1992) Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes. Mol. Biol. Cell, 3, 49-61.
26. Parent, C.A. and Devreotes, P.N. (1999) A cell's sense of direction. Science, 284, 765-770.
27. Pronin, A.N. and Gautam, N. (1993) Proper processing of a G protein gamma subunit depends on complex formation with a β subunit. FEBS Lett., 328, 89-93.
28. Reig, J.A., Yu, L. and Klein, D.C. (1990) Pineal transduction. Adrenergic-cyclic AMP-dependent phosphorylation of cytoplasmic 33-kDa protein (MEKA) which binds βγ-complex of transducin. J. Biol. Chem., 265, 5816-5824.
29. Ross, E.M. and Wilkie, T.M. (2000) GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem., 69, 795-827.
30. Savage, J.R., McLaughlin, J.N., Skiba, N.P., Hamm, H.E. and Willardson, B.M. (2000) Functional roles of the two domains of phosducin and phosducin-like protein. J. Biol. Chem., 275, 30399-30407.
31. Schroder, S. and Lohse, M.J. (1996) Inhibition of G-protein βγ-subunit functions by phosducin-like protein. Proc. Natl Acad. Sci. USA, 93, 2100-2104.
32. Schroder, S. and Lohse, M.J. (2000) Quantification of the tissue levels and function of the G-protein regulator phosducin-like protein (PhlP). Naunyn Schmiedebergs Arch. Pharmacol., 362, 435-439.
33. Snaar-Jagalska, B.E. and Van Haastert, P.J. (1994) G-protein assays in Dictyostelium. Methods Enzymol., 237, 387-408.
34. Sutoh, K. (1993) A transformation vector for Dictyostelium discoideum with a new selectable marker bsr. Plasmid, 30, 150-154.
35. Thompson, J.D., Higgins, D.G. and Gibson, T.J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.
36. Van Haastert, P.J.M. (1984) Guanine nucleotides modulate cell surface cAMP-binding sites in membranes from Dictyostelium discoideum. Biochem. Biophys. Res. Commun., 124, 597-604.
37. Van Haastert, P.J.M. and Kuwayama, H. (1997) cGMP as second messenger during Dictyostelium chemotaxis. FEBS Lett., 410, 25-28.
38. Van Haastert, P.J.M., De Wit, R.J., Janssens, P.M., Kesbeke, F. and DeGoede, J. (1986) G-protein-mediated interconversions of cell-surface cAMP receptors and their involvement in excitation and desensitization of guanylate cyclase in Dictyostelium discoideum. J. Biol. Chem., 261, 6904-6911.
39. Wu, L., Valkema, R., Van Haastert, P.J. and Devreotes, P.N. (1995) The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium. J. Cell Biol., 129, 1667-1675.
40. Zhang, N., Long, Y. and Devreotes, P.N. (2001) Ggamma in Dictyostelium: its role in localisation of gbetagamma to the membrane is required for chemotaxis in shallow gradients. Mol. Biol. Cell, 12, 3204-3213.