Functional role of the linker region in purified human P-glycoprotein

FEBS Journal

Volumn 276, Issue 13, 2009, Pages 3504-3516

  Sato, Tomomi ^a   Kodan, Atsushi ^b   Kimura, Yasuhisa ^a   Ueda, Kazumitsu ^a,b   Nakatsu, Toru ^a   Kato, Hiroaki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

ATPase activity; Limited proteolysis; Linker region; MDR1; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CALCEIN; COLCHICINE; DIGOXIN; GLYCOPROTEIN P; MSBA PROTEIN; NICARDIPINE; PACLITAXEL; RHODAMINE 123; RHODAMINE B; VALINOMYCIN; VERAPAMIL; VINBLASTINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; THERMOSTABILITY;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; CHROMATOGRAPHY, GEL; CHYMOTRYPSIN; DRUG RESISTANCE, MULTIPLE; HUMANS; HYDROLYSIS; LIPOSOMES; MICELLES; MODELS, MOLECULAR; P-GLYCOPROTEIN; PEPTIDE HYDROLASES; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TRYPSIN;

EID: 67650498383     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07072.x     Document Type: Article

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