The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to α- and β-tubulins

Biochemistry

Volumn 46, Issue 25, 2007, Pages 7337-7342

  Georges, Elias ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELLS; DRUG DELIVERY; DRUG PRODUCTS; GENE ENCODING; HYDROPHILICITY; HYDROPHOBICITY; TUMORS;

HYDROPHILIC DOMAINS; MULTIDRUG RESISTANCE; TUMOR CELL LINES;

GLYCOPROTEINS;

ALPHA TUBULIN; ANTINEOPLASTIC AGENT; BETA TUBULIN; CELL PROTEIN; HEXAPEPTIDE; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN 1; POLYPEPTIDE; PROTEIN P57;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; TUMOR CELL LINE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; BINDING SITES; CELL EXTRACTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P57; HUMANS; METHIONINE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; OLIGOPEPTIDES; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; SULFUR RADIOISOTOPES; TUBULIN;

EID: 34250885126     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7006228     Document Type: Article

References (41)

1. Ling, V. (1997) Multidrug resistance: Molecular mechanisms and clinical relevance, Cancer Chemother. Pharmacol. 40 (Suppl.), S3-S8.
2. Gottesman, M. M., Hrycyna, C. A., Schoenlein, P. V., Germann, U. A., and Pastan, I. (1995) Genetic analysis of the multidrug transporter, Annu. Rev. Genet. 29, 607-649.
3. Deeley, R. G., and Cole, S. P. C. (2006) Substrate recognition and transport by multidrug resistance protein 1 (ABCC1), FEBS Lett. 580, 1103-1111.
4. Dean, M., Rzhetsky, A., and Allikmets, R. (2001) The human ATP-binding cassette (ABC) transporter superfamily, Genome Res. 11, 1156-1166.
5. Shilling, R. A., et al. (2006) New light on multidrug biding by an ATP-binding cassette transporter, Trends Pharmacol. Sci. 27, 195-203.
6. Kast, C., and Gros, P. (1997) Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence, J. Biol. Chem. 272, 26479-26487.
7. O'Brien, J. P., and Cordon-Cardo, C. (1996) P-Glycoprotein Expression in Normal Human Tissues, in Multidrug Resistance in Cancer Cells: Molecular, Biochemical, Physiological and Biological Aspects (Gupta, S., and Tsuruo, T., Eds.) pp 285-292, Wiley, New York.
8. Gupta, S. (1996) P-Glycoprotein Expression in Normal Hematopoietic Pregenitors and Cells of the Immune System, in Multidrug Resistance in Cancer Cells: Molecular, Biochemical, Physiological and Biological Aspects (Gupta, S., and Tsuruo, T., Eds.) pp 293-302, Wiley, New York.
9. Cornelissen, J. J., Sonneveld, P., Schoester, M., Raaijmakers, H. G., Nieuwenhuis, H. K., Dekker, A. W., and Lokhorst, H. M. (1994) MDR-1 expression and response to vincristine, doxorubicin, and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents, J. Clin. Oncol. 12, 115-119.
10. Nooter, K., and Sonneveld, P. (1994) Clinical relevance of P-glycoprotein expression in haematological malignancies, Leuk. Res. 18, 233-243.
11. Bates, S. E., Meadows, B., Goldspiel, B. R., Denicoff, A., Le, T. B., Tucker, E., Steinberg, S. M., and Elwood, L. J. (1995) A pilot study of amiodarone with infusional doxorubicin or vinblastine in refractory breast cancer, Cancer Chemother. Pharmacol. 35, 457-463.
12. Verrelle, P., Meissonnier, F., Fonck, Y., Feillel, V., Dionet, C., Kwiatkowski, F., Plagne, R., and Chassagne, J. (1991) Clinical relevance of immunohistochemical detection of multidrug detection of multidrug resistance P-glycoprotein in breast carcinoma, J. Natl. Cancer Inst. 83, 111-116.
13. Chan, H. S., DeBoer, G., Haddad, G., Gallie, B. L., and Ling, V. (1995) Multidrug resistance in pediatric malignancies, Hematol.-Oncol. Clin. North Am. 9, 275-318.
14. Chan, H. S., Haddad, G., Thorner, P. S., DeBoer, G., Lin, Y. P., Ondrusek, N., Yeger, H., and Ling, V. (1991) P-Glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma, N. Engl. J. Med. 325, 1608-1614.
15. Szakacs, G., Peterson, J. K., Ludwig, J. A., Booth-Genthe, C., and Gottesman, M. M. (2006) Targeting multidrug resistance in cancer, Nat. Rev. Drug Discovery 5, 219-234.
16. Ahmad, S., Safa, A. A., and Glazer, R. I. (1994) Modulation of P-glycoprotein by protein-kinase C-α in a baculovirus expression system, Biochemistry 33, 10313-10318.
17. Chambers, T. C., Pohl, J., Glass, D. B., and Kuo, J. F. (1994) Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein, Biochem. J. 299, 309-315.
18. Bates, S. E., Lee, J. S., Dickstein, B., Spolyar, M., and Fojo, J. S. (1993) Differential modulation of P-glycoprotein transport by protein kinase inhibition, Biochemistry 37, 9156-9164.
19. Chambers, T. C., Chalikonda, I., and Eilon, G. (1990) Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells, Biochem. Biophys. Res. Commun. 169, 253-259.
20. Fine, R. L., Patel, J., and Chabner, B. A. (1988) Phorbol esters induce multidrug resistance in human breast, Proc. Natl. Acad. Sci. U.S.A. 85, 582-586.
21. Bates, S. E., Currier, S. J., Alvarez, M., and Fojo, M. (1992) Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate, Biochemistry 31, 6366-6372.
22. Germann, U. A., Chambers, M. S., Ambudkar, A., Licht, T., Cardarelli, C. O., Pastan, I., and Gottesman, M. M. (1996) Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells, J. Biol. Chem. 271, 1708-1716.
23. Valverde, M. A., Sepulveda, F. V., Gill, D. R., Hyde, S. C., and Higgins, C. F. (1992) Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein, Nature 355, 830-833.
24. Beck, W. T. (1983) Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts, Cancer Treat. Rep. 67, 875-882.
25. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein Measurement with Folin phenol reagent, J. Biol. Chem. 193, 265-275.
26. Georges, E., Tsuruo, T., and Ling, V. V. (1993) Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody, J. Biol. Chem. 268, 1792-1798.
27. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-685.
28. Towbin, H., Staehelin, T., and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications, Proc. Natl. Acad. Sci. U.S.A. 76, 4350-4354.
29. Edman, P., and Begg, G. (1967) A protein sequenator, Eur. J. Biochem. 1, 80-91.
30. Flynn, T. G., de Bold, M. L., and de Bold, A. J. (1983) The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties, Biochem. Biophys. Res. Commun. 117, 859-865.
31. Chambers, T. C., Pohl, J., Raynor, R. L., and Kuo, J. F. (1993) Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C, J. Biol. Chem. 268, 4592-4595.
32. Glavy, J. S., Horwitz, S. B., and Orr, G. A. (1997) Identification of the in vivo phosphorylation sites for acidic-directed kinases in murine mdr1b P-glycoprotein, J. Biol. Chem. 272, 5909-5914.
33. Kuriyan, J., and Cowburn, D. (1997) Modular peptide recognition domains in eukaryotic signaling, Annu. Rev. Biophys. Biomol. Struct. 26, 259-288.
34. Haga, K., Ogawa, H., Haga, T., and Murofushi, H. (1988) GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin, Eur. J. Biochem. 255, 363-368.
35. Giustetto, M., Kirsch, J., Fritschy, J. M., Cantino, D., and Sassoe-Pognetto, M. (1998) Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat, J. Comp. Neurol. 395, 231-244.
36. Perrot-Applanat, M., Cibert, C., Geraud, G., Renoir, J. M., and Baulieu, E. E. (1995) The 59 kDa FK506-binding protein, a 90 kDa heat shock protein binding immunophilin (FKBP59-HBI), is associated with the nucleus, the cytoskeleton and mitotic apparatus, J. Cell Sci. 108, 2037-2051.
37. Ravindra, R. (1997) Is signal transduction modulated by an interaction between heterotrimeric G-proteins and tubulin? Endocrine 7, 127-143.
38. Jacobson, K., Sheets, E. D., and Simson, R. (1995) Revsiting the fluid mosaic model of membranes, Sciences 268, 1441-1442.
39. Sako, Y., and Kusumi, A. (1995) Barriers for lateral diffusion of transferrin receptor in the plasma membrane as characterized by receptor dragging by laser tweezers: Fence versus tether, J. Cell Biol. 129, 1559-1574.
40. Lee, C. H., Bradley, G., and Ling, V. (1998) Increased P-glycoprotein messenger RNA stability in rat liver tumors in vivo, J. Cell. Physiol. 177, 1-12.
41. 2+ or microfilaments, J. Cell Sci. 109, 1325-1334.