Proteolytic Cleavage of the Linker Region of the Human P-glycoprotein Modulates Its ATPase Function

Journal of Biological Chemistry

Volumn 277, Issue 33, 2002, Pages 29417-29423

  Nuti, Shanthy L ^a   Rao, U Subrahmanyeswara ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; DRUG PRODUCTS; TUMORS;

ANTICANCER DRUG-TRANSLOCATING ATPASE; MULTIDRUG RESISTANCE; PROTEOLYSIS; TRYPSIN;

ENZYMES;

ADENOSINE TRIPHOSPHATASE; ARGININE; CHYMOTRYPSIN; GLYCOPROTEIN P; LEUCINE; PROTEINASE K; TRYPSIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; ARMYWORM; HYDROLYSIS; METABOLISM; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROLYSIS; MUTATION; P-GLYCOPROTEIN; SPODOPTERA;

EID: 0037119402     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204054200     Document Type: Article

References (50)

1. Gottesman, M. M. (1993) Cancer Res. 53, 747-754
2. Gottesman, M. M., Fojo, T., and Bates, S. E. (2002) Nat. Rev. Cancer 2, 48-58
3. Ling, V. (1997) Cancer Chemother. Pharmacol. 40, (suppl.) S3-S8
4. Juliano, R. L., and Ling, V. (1976) Biochim. Biophys. Acta 455, 152-162
5. Pastan, I., and Gottesman, M. M. (1991) Annu. Rev. Med. 42, 277-286
6. Gennann, U. A. (1996) Eur. J. Cancer 32(6), 927-944
7. Tan, B., Piwnica-Worros, D., and Ratner, L. (2000) Curr. Opin. Oncol. 12, 450-458
8. Chen, C. J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., and Roninson, I. B. (1986) Cell 47, 381-389
9. Higgins, C. F. (1992) Annu. Rev. Cell Biol. 8, 67-113
10. Hrycyna, C. A., Airan, L. E., Germann, U. A., Ambudkar, S. V., Pastan, I., and Gottesman, M. M. (1998) Biochemistry 37, 13660-13673
11. Walker, J. E., Saraste, M., Runswick, M. J., and Gay, N. J. (1982) EMBO J. 1, 945-951
12. Hrycyna, C. A., Ramachandra, M., Germann, U. A., Cheng, P. W., Pastan, I., and Gottesman, M. M. (1999) Biochemistry 38, 13887-13899
13. Georges, E., Zhang, J. T., and Ling, V. (1991) J. Cell. Physiol. 148, 479-484
14. Urbatsch, I. L., Sankaran, B., Bhagat, S., and Senior, A. E. (1995) J. Biol. Chem. 270, 26956-26961
15. Chambers, T. C., Pohl, J., Raynor, R. L., and Kuo, J. F. (1993) J. Biol. Chem. 268, 4592-4595
16. Riordan, J. R., Rommens, J. M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J. L., Drumm, M. L., Iannuzzi, M. C., Collins, F. S., and Tsui, L. C. (1989) Science 245, 1066-1073
17. Orr, G. A., Han, E. K., Browne, P. C., Nieves, E., O'Connor, B. M., Yang, C. P., and Horwitz, S. B. (1993) J. Biol. Chem. 268, 25054-25062
18. Germann, U. A., Chambers, T. C., Ambudkar, S. V., Licht, T., Cardarelli, C. O., Pastan, I., and Gottesman, M. M. (1996) J. Biol. Chem. 271, 1708-1716
19. Szabo, K., Bakos, E., Welker, E., Muller, M., Goodfellow, H. R., Higgins, C. F., Varadi, A., and Sarkadi, B. (1997) J. Biol. Chem. 272, 23165-23171
20. Germann, U. A. (1998) Methods Enzymol. 292, 427-441
21. Germann, U. A., Willingham, M. C., Pastan, I., and Gottesman, M. M. (1990) Biochemistry 29, 2295-2303
22. Loo, T. W., and Clarke, D. M. (1993) J. Biol. Chem. 268, 19965-19972
23. Loo, T. W., and Clarke, D. M. (1994) Biochemistry 33, 14049-14057
24. Rao, V. V., Chiu, M. L., Kronauge, J. F., and Piwnica-Worms, D. (1994) J. Nucl. Med. 35, 510-515
25. Rao, U. S. (1995) J. Biol. Chem. 270, 6686-6690
26. Rao, U. S. (1998) Biochemistry 37, 14981-14988
27. Sarkadi, B., Price, E. M., Boucher, R. C., Germann, U. A., and Scarborough, G. A. (1992) J. Biol. Chem. 267, 4854-4858
28. Nuti, S. L., Mehdi, A., and Rao, U. S. (2000) Biochemistry 39, 3424-3432
29. Shapiro, A. B., and Ling, V. (1994) J. Biol. Chem. 269, 3745-3754
30. Sharom, F. J., Yu, X., Chu, J. W., and Doige, C. A. (1995) Biochem. J. 308, 381-390
31. Ambudkar, S. V., Lelong, I. H., Zhang, J., Cardarelli, C. O., Gottesman, M. M., and Pastan, I. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8472-8476
32. al-Shawi, M. K., and Senior, A. E. (1993) J. Biol. Chem. 268, 4197-4206
33. Senior, A. E., al-Shawi, M. K., and Urbatsch, I. L. (1998) Methods Enzymol. 292, 514-523
34. Rao, U. S., Fine, R. L., and Scarborough, G. A. (1994) Biochem. Pharmacol. 48, 287-292
35. Shapiro, A. B., and Ling, V. (1998) Acta Physiol. Scand. Suppl. 643, 227-234
36. Welker, E., Szabo, K., Hollo, Z., Muller, M., Sarkadi, B., and Varadi, A. (1995) Biochem. Biophys. Res. Commun. 216, 602-609
37. Shepard, R. L., Winter, M. A., Hsaio, S. C., Pearce, H. L., Beck, W. T., and Dantzig, A. H. (1998) Biochem. Pharmacol. 56, 719-727
38. Muller, M., Bakos, E., Welker, E., Varadi, A., Germann, U. A., Gottesman, M. M., Morse, B. S., Roninson, I. B., and Sarkadi, B. (1996) J. Biol. Chem. 271, 1877-1883
39. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
40. Rao, U. S., Mehdi, A., and Steimle, R. E. (2000) Anal. Biochem. 286, 206-213
41. Baumann, W. K., Bizzozero, S. A., and Dutler, H. (1970) FEES Lett. 8, 257-260
42. Berezin, I. V., and Martinek, K. (1970) FEBS Lett, 8, 261-262
43. Nuti, S. L., Mehdi, A., and Rao, U. S. (2000) FASEB J. 14, A1468
44. Julien, M., and Gros, P. (2000) Biochemistry 39, 4559-4568
45. Wang, G., Pincheira, R., Zhang, M., and Zhang, J. T. (1997) Biochem. J. 328, 897-904
46. Senior, A. E., al-Shawi, M. K., and Urbatsch, I. L. (1995) FEBS Lett. 377, 285-289
47. Senior, A. E. (1998) Acta Physiol. Scand. Suppl. 643, 213-218
48. Berman, M. C. (2001) Biochim. Biophys. Acta 1513, 95-121
49. Sauna, Z. E., and Ambudkar, S. V. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2515-2520
50. Loo, T. W., and Clarke, D. M. (1994) J. Biol. Chem. 269, 7750-7755