Obestatin stimulates Akt signalling in gastric cancer cells through β-arrestin-mediated epidermal growth factor receptor transactivation

Endocrine-Related Cancer

Volumn 16, Issue 2, 2009, Pages 599-611

  Álvarez, Carlos J P ^a,b   Lodeiro, María ^a,b   Theodoropoulou, Marily ^a,c   Camiña, Jesús P ^a,b   Casanueva, Felipe F ^a,b,d   Pazos, Yolanda ^a,b  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN C2; MATRIX METALLOPROTEINASE; OBESTATIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; UNCLASSIFIED DRUG; BETA ARRESTIN; EGFR PROTEIN, HUMAN; OBESTATIN, HUMAN; PEPTIDE HORMONE; PHOSPHATIDYLINOSITOL 3 KINASE; RETINA S ANTIGEN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE REGULATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE ACTIVATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; METABOLISM; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH CANCER; TRANSACTIVATION; DRUG ANTAGONISM; GENETICS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PATHOLOGY; PHOSPHORYLATION; STOMACH TUMOR; TRANSCRIPTION INITIATION; TUMOR CELL CULTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ARRESTINS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PEPTIDE HORMONES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TRANSCRIPTIONAL ACTIVATION; TUMOR CELLS, CULTURED;

EID: 67650485948     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-08-0192     Document Type: Article

References (50)

1. Bhola NE & Grandis JR 2008 Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer. Frontiers in Bioscience 13 1857-1865.
2. Bresciani E, Rapetti D, Dòna F, Bulgarelli I, Tamiazzo L, Locatelli V & Torsello A 2006 Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. Journal of Endocrinological Investigation 29 RC16-RC18.
3. Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM & DuBois RN 2006 Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. PNAS 103 1492-1497.
4. Camiña JP, Campos JF, Caminos JE, Dieguez C & Casanueva FF 2007a Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms. Journal of Cellular Physiology 211 1-9.
5. Camiña JP, Lodeiro M, Ischenko O, Martini AC & Casanueva FF 2007b Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and beta-arrestins. Journal of Cellular Physiology 213 187-200.
6. Carlini VP, Schioth HB & Debarioglio SR 2007 Obestatin improves memory performance and causes anxiolytic effects in rats. BIochemical and Biophysical Research Communications 352 907-912.
7. Carpenter G 2000 EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists. Science's STKE: Signal Transduction Knowledge Environment PE1.
8. Casamayor A, Morrice NA & Alessi DR 1999 Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. Biochemical Journal 342 287-292.
9. Chartrel N, Alvear-Perez R, Leprince J, Iturrioz X, Reaux-Le Goazigo A, Audinot V, Chomarat P, Coge F, Nosjean O, Rodriguez M et al. 2007 Comment on 'Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake'. Science 315 766.
10. Chiu T, Santiskulvong C & Rozengurt E 2005 EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through PI3-kinase/Akt/m-TOR/p70S6K1 signalling pathway. American Journal of Physiology. Gastrointestinal and Liver Physiology 288 G182-G194.
11. DeFea KA, Vaughn ZD, O'Bryan EM, Nishijima D, Dery O & Bunnett NW 2000 The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex. PNAS 97 11086-11091.
12. Dun SL, Brailoiu GC, Brailoiu E, Yang J, Chang JK & Dun NJ 2006 Distribution and biological activity of obestatin in the rat. Journal of Endocrinology 191 481-489.
13. Gourcerol G, Million M, Adelson DW, Wang Y, Wang L, Rivier J, St-Pierre DH & Taché Y 2006 Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signalling in rodents. Peptides 27 2811-2819.
14. Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E et al. 2008 Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function. Diabetes 57 967-979.
15. Guertin DA & Sabatini DM 2007 Defining the role of mTOR in cancer. Cancer Cell 12 9-22.
16. Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H & Matsushita N 2008 Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Science 99 214-220.
17. Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG et al. 2007 GPR39 signalling is stimulated by zinc ions but not by obestatin. Endocrinology 148 13-20.
18. Huovila AP, Turner AJ, Pleto-Huikko M, Karkkaine I & Ortiz RM 2005 Shedding light on ADAM metalloproteinases. Trends in Biochemical Sciences 30 413-422.
19. Hwang JJ, Park MH, Choi SY & Koh JY 2005 Activation of the Trk signalling pathway by extracellular zinc. Role of metalloproteinases. Journal of Biological Chemistry 280 11995-12001.
20. Kenerson HL, Aicher LD, True LD & Yeung RS 2002 Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Research 62 5645-5650.
21. Lagaud GJ, Young A, Acena A, Morton MF, Barrett TD & Shankley NP 2007 Obestatin reduces food intake and suppresses body weight gain in rodents. Biochemical and Biophysical Research Communications 357 264-269.
22. Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR III, Parent CA & Firtel RA 2005 TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Molecular Biology of the Cell 16 4572-4583.
23. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK et al. 1999 Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283 655-661.
24. Manning BD & Cantley LC 2007 AKT/PKB signalling: navigating downstream. Cell 129 1261-1274.
25. Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vazquez MJ, Wiedmer P, Castañeda TR et al. 2007 Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 148 21-26.
26. Noma T, Lemaire A, Prassad SVN, Barki-Harrinton L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz R et al. 2007 Beta-arrestin-mediated beta1-adrrenergic receptor transactivation of EGFR confers cardioprotection. Journal of Clinical Investigation 117 2445-2458.
27. Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F & Salomon DS 2006 Epidermal growth factor receptor (EGFR) signalling in cancer. Gene 366 2-16.
28. Ohtsu H, Dempsey PJ & Eguchi S 2006 ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. American Journal of Physiology. Cell Physiology 291 C1-C10.
29. Olayioye MA, Neve1 RM, Lane HA & Hynes NE 2000 The ErbB signalling network: receptor heterodimerization in development and cancer. EMBO Journal 19 3159-3167.
30. Pazos Y, Alvarez CJ, Camiña JP & Casanueva FF 2007 Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. Growth Factors 25 373-381.
31. Prenzel N, Fischer OM, Streit S, Hart S & Ullrich A 2001 The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocrine-Related Cancer 8 11-31.
32. Pullen N & Thomas G 1997 The modular phosphorylation and activation of p70S6K. FEBS Letters 410 78-82.
33. Reynolds TH IV, Bodine SC & Lawrence JC Jr 2002 Control of Ser2448 phosphorylation in the mammalian target of rapamicin by insulin and skeletal muscle load. Journal of Biological Chemistry 277 17657-17662.
34. 2+-induced signal initiation through the epidermal growth factor receptor. Toxicology and Applied Pharmacology 191 86-93.
35. Samson WK, White MM, Price C & Ferguson AV 2007 Obestatin acts in brain to inhibit thirst. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 292 R637-R643.
36. Schroder WA, Buck M, Cloonan N, Hancock JF, Suhrbier A, Sculley T & Bushell G 2007 Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. Cellular Signalling 19 1279-1289.
37. Seals DF & Courtneidge SA 2003 The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes & Development 17 7-30.
38. Seoane LM, Al-Massadi O, Pazos Y, Pagotto U & Casanueva FF 2006 Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. Journal of Endocrinological Investigation 29 RC13-RC15.
39. Storjohann L, Holst B & Schwartz TW 2008 Molecular mechanism of Zn(2+) agonism in the extracellular domain of GPR39. FEBS Letters 582 2583-2588.
40. Storz P & Toker A 2002 3′-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signalling. Frontiers in Bioscience 7 886-902.
41. Szentirmai E & Krueger JM 2006 Obestatin alters sleep in rats. Neuroscience Letters 404 222-226.
42. Theodoropoulou M, Zhang J, Laupheimer S, Paez-Pereda M, Erneux C, Florio T, Pagotto U & Stalla GK 2006 Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signalling and inducing Zac1 expression. Cancer Research 66 1576-1582.
43. Tremblay F, Perreault M, Klaman LD, Tobin JF, Smith E & Gimeno RE 2007 Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39. Endocrinology 148 501-506.
44. Wu W, Graves LM, Gill GN, Parsons SJ & Samet JM 2002 Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. Journal of Biological Chemistry 277 24252-24257.
45. Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA & Graves LM 2004 Heparing-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. American Journal of Respiratory Cell and Molecular Biology 30 540-547.
46. 2+-induced cyclooxygenase-2 expression. American Journal of Physiology. Lung Cellular and Molecular Physiology 289 L883-L889.
47. Yamamoto D, Ikeshita N, Daito R, Herningtyas EH, Toda K, Takahashi K, Iida K, Takahashi Y, Kaji H, Chihara K et al. 2007 Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regulatory Peptides 138 141-144.
48. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C & Hsueh AJ 2005 Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310 996-999.
49. Zhang JV, Jahr H, Luo CW, Klein C, Van Kolen K, Ver Donck L, De A, Baart E, Li J, Moechars D et al. 2008 Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39. Molecular Endocrinology 22 1464-1475.
50. Zizzari P, Longchamps R, Epelbaum J & Bluet-Pajot MT 2007 Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology 148 1648-1653.