Synthesis, biological evaluation and docking studies of novel benzopyranone congeners for their expected activity as anti-inflammatory, analgesic and antipyretic agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5059-5070

  Eissa, Amal A M ^a   Farag, Nahla A H ^b   Soliman, Gamal A H ^c  

^a CAIRO UNIVERSITY   (Egypt)

^b Egypt   (Egypt)

^c Cairo University   (Egypt)

Author keywords

Analgesic; Anti inflammatory; Antipyretic; Benzopyranone; Coumarin; Docking; Internal coordinate mechanics (ICM)

Indexed keywords

4 (N,N DIMETHYLAMINOPHENYL) 6 (7 HYDROXY 2 OXO 4 PHENYL 2H 1 BENZOPYRAN 8 YL) 2 IMINO 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 8 [3 (4 N,N DIMETHYLAMINOPHENYL)ACETYLOYL] 7 HYDROXY 4 PHENYL 2H 1 BENZOPYRAN 2 ONE; 8 [5 (4 ANISOYL) 1 PHENYL 4,5 DIHYDRO 1H 1 PYRAZOL 3 YL] 7 HYDROXY 4 PHENYL 2H 1 BENZOPYRAN 2 ONE; 8 [5 (4 N,N DIMETHYLAMINOPHENYL) 1 (2,4 DINITROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 HYDROXY 4 PHENYL 2H 1 BENZOPYRAN 2 ONE; 8 ACETYL 7 HYDROXY 4 PHENYL 2H 1 BENZOPYRAN 2 ONE; 8 ACETYL 7 HYDROXY 4 PHENYL 2H BENZOPYRAN 2 ONE DERIVATIVE; BENZOPYRAN DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2; DICLOFENAC; INDOMETACIN; SERINE; TYROSINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYPERPYREXIA; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PAIN; PAW EDEMA; RAT; REACTION ANALYSIS; WRITHING TEST;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOPYRANS; CATALYTIC DOMAIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; EDEMA; EXTREMITIES; FEVER; MALE; MICE; MODELS, MOLECULAR; PROTEIN BINDING; RATS;

EID: 67650264156     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.073     Document Type: Article

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