Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

Farmaco

Volumn 54, Issue 4, 1999, Pages 195-201

  Abadi, Ashraf ^a   Al Deeb, Omar ^a   Al Afify, Ahmed ^a   El Kashef, Hassan ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

2(1H) pyridinones; Cardiotonics; Milrinone analogues

Indexed keywords

3 CYANO 6 (3,4 DIMETHOXYPHENYL) 4 (4 HYDROXYPHENYL) 2(1H) PYRIDINONE; 4 ALKYL 3 CYANO 2(1H) IMINOPYRIDINE; 4 ALKYL 3 CYANO 2(1H) PYRIDINONE; ACETOPHENONE; ALDEHYDE; AMMONIUM ACETATE; CARDIOTONIC AGENT; MALONONITRILE; PYRIDONE DERIVATIVE; RESERPINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ATRIUM; HEART CONTRACTION; HEART MUSCLE CONTRACTILE FORCE; HEART RATE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION;

ANIMALS; ATRIAL FUNCTION; CARDIOTONIC AGENTS; GUINEA PIGS; HEART ATRIA; LETHAL DOSE 50; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MYOCARDIAL CONTRACTION; PYRIDONES; SPECTROPHOTOMETRY, INFRARED;

EID: 0033617593     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(99)00004-X     Document Type: Article

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