Synthesis and evaluation of novel 7-trifluoromethyl-4-(4-substituted anilino) quinolines as antiparasitic and antineoplastic agents

Arzneimittel-Forschung/Drug Research

Volumn 53, Issue 9, 2003, Pages 655-663

  Abadi, Ashraf H ^a   Brun, Reto ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

7 Trifluoromethyl 4 4 substituted anilino)quinolines, antiparasitic and antineoplastic activity, synthesis; Antineoplastic agents; Antiparasitic agents; Quinolines

Indexed keywords

1 [4 [[7 (TRIFLUOROMETHYL)QUINOLIN 4 YL]AMINO]PHENYL]ETHAN 1 ONE N METHYLTHIOSEMICARBAZONE; 1 [4 [[7 (TRIFLUOROMETHYL)QUINOLIN 4 YL]AMINO]PHENYL]ETHAN 1 ONE SEMICARBAZONE; 1 [4 [[7 (TRIFLUOROMETHYL)QUINOLIN 4 YL]AMINO]PHENYL]ETHAN 1 ONE THIOSEMICARBAZONE; 1 [5 (4 CHLOROPHENYL) 3 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL] 4,5 DIHYDROPYRAZOL 1 YL]ETHANONE; 1 [5 (4 DIMETHYLAMINOPHENYL) 3 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL] 4,5 DIHYDROPYRAZOL 1 YL]ETHANONE; 1 [5 (4 METHOXYPHENYL) 3 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL] 4,5 DIHYDROPYRAZOL 1 YL]ETHANONE; 1 [5 NAPHTHALEN 2 YL 3 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL] 4,5 DIHYDROPYRAZOL 1 YL]ETHANONE; 1 [5 PHENYL 3 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL] 4,5 DIHYDROPYRAZOL 1 YL]ETHANONE; 3 (4 CHLOROPHENYL) 1 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL]PROPENONE; 3 (4 DIMETHYLAMINOPHENYL) 1 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL]PROPENONE; 3 (4 METHOXYPHENYL) 1 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL]PROPENONE; 3 NAPHTHALEN 2 YL 1 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL]PROPENONE; 3 PHENYL 1 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YLAMINO)PHENYL]PROPENONE; 4 (4 ACETYLANILINO) 7 TRIFLUOROMETHYLQUINOLINE; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; N [4 (5 NAPHTHALEN 2 YL 4,5 DIHYDROISOXAZOL 3 YL)PHENYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 (5 PHENYL 4,5 DIHYDROISOXAZOL 3 YL)PHENYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 [5 (4 CHLOROPHENYL) 4,5 DIHYDROISOXAZOL 3 YL]PHENYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 [5 (4 DIMETHYLAMINOPHENYL) 4,5 DIHYDROISOXAZOL 3 YL]PHENYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 [5 (4 METHOXYPHENYL) 4,5 DIHYDROISOXAZOL 3 YL]PHENYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; HUMAN; HUMAN CELL; IC 50; LEISHMANIA DONOVANI; MOUSE; MYOBLAST; NONHUMAN; PERITONEUM MACROPHAGE; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

EID: 0141649557     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299808     Document Type: Article

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