Treatment of congestive heart failure: Interfering the aldosterone-cardiac extracellular matrix relationship

Hypertension

Volumn 38, Issue 5, 2001, Pages 1227-1232

  Zannad, Faiez ^a   Dousset, Brigitte ^a   Alla, François ^a  

^a Ctr Hospitalier Univ de Nancy   (France)

Author keywords

Aldosterone; Collagen; Extracellular matrix; Heart failure; Renin angiotensin system

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN RECEPTOR ANTAGONIST; SPIRONOLACTONE;

CLINICAL TRIAL; COLLAGEN METABOLISM; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; EXTRACELLULAR MATRIX; HEART DILATATION; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE HYPERTROPHY; HUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0035724041     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/hy1101.099484     Document Type: Conference Paper

References (49)

1. Collagen production and replication by cardiac fibroblasts is enhanced in response to diverse classes of growth factors
2. Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts
3. Regulation and role of myocardial collagen matrix remodeling in hypertensive heart disease
4. Angiotensin Il induces TIMP-1 production in rat heart endothelial cells
5. Effects of angiotensin converting enzyme inhibitors and angiotensin II type I receptor antagonists in rats with heart failure
6. Molecular mechanisms of myocardial remodeling
7. Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio
8. Alteration of cardiac collagen phenotypes in hypertension hypertrophy: Role of blood pressure
9. Alteration of collagen phenotypes in ischemic cardiomyopathy
10. Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts
11. Lisinopril mediated regression of myocardial fibrosis in patients with hypertensive heart disease
12. Treatment with lisinopril normalizes serum concentrations of procollagen type III amino-terminal peptide in patients with essential hypertension
13. 1 blockade stimulates extracellular collagen type I degradation and reverses myocardial fibrosis in spontaneously hypertensive rats
14. Role of myocytes in myocardial collagen production
15. The effects of endothelin-1 on collagen type I and type III synthesis in cultured porcine coronary artery vascular smooth muscle cells
16. Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure
17. Monitoring tissue repair and fibrosis from a distance
18. Collagen scar formation after acute myocardial infarction: Relationships to infarct size, left ventricular function, and coronary artery patency
19. Measuring serum aminoterminal type III procollagen peptide, 7S domain of type IV collagen, and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy
20. The amino-terminal propeptide of type III procollagen provides new information on prognosis after acute myocardial infarction
21. Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis
22. Increased serum concentration of procollagen peptides in essential hypertension: Relation to cardiac alteration
23. Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease
24. Changes of serum markers of cardiac extra-cellular matrix turnover in heart failure and high risk patients
25. Studies on collagen in the experimental myocardial infarction
26. Radioimmunoassay of the carboxy-terminal propeptide of human type I procollagen
27. Analysing connective tissue metabolites in human serum: Biochemical, physiological and methodological aspects
28. Serum amino-terminal type III procollagen peptide reflects repair after myocardial infarction
29. Thrombolytic therapy with streptokinase stimulates collagen breakdown
30. Relationship between serum amino-terminal propeptide of type III procollagen and changes of left ventricular function after acute myocardial infarction
31. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: Insights from the Randomized Aldactone Evaluation Study (RALES)
32. Categorizing a prognostic variable: Review of methods, code for easy implementation and applications to decision-making about cancer treatments
33. Incidence, clinical and etiologic features, and outcomes of advanced chronic heart failure: The EPICAL Study; Epidémiologie de l'insuffisance cardiaque avancée en Lorraine
34. Matrix metalloproteinases, their inhibitors in connective tissue remodeling
35. Tissue inhibitor of metalloproteinases (TIMP aka EPA): Structure, control of expression and biological functions
36. Aldosterone production is activated in failing ventricle in humans
37. Antagonism of the renin angiotensin aldosterone system and collagen metabolism in cardiac fibroblasts
38. Aldosterone and the heart: Towards a physiological function?
39. Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: In Vivo and in vitro studies on collagen matrix regulation
40. Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension
41. Reactive and reparative myocardial fibrosis in arterial hypertension in the rat
42. Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats
43. Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients
44. The effect of spironolactone on morbidity and mortality in patients with severe heart failure
45. Aldosterone and spironolactone in heart failure
46. Angiotensin-converting enzyme inhibitor and spironolactone combination therapy: New objectives in congestive heart failure treatment
47. Aldosterone and heart failure
48. Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction
49. The EPHESUS Trial: Eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction