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Volumn 54, Issue 1, 1998, Pages 58-67

Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A (HMG CoA) reductase; Alzheimer's disease; Apolipoprotein E; Apoptosis; Cholesterol synthesis; Neuronal cell death

Indexed keywords

APOLIPOPROTEIN E4; COMPACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; SQUALENE;

EID: 0032189866     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19981001)54:1<58::AID-JNR7>3.0.CO;2-G     Document Type: Article
Times cited : (64)

References (41)
  • 1
    • 0030928650 scopus 로고    scopus 로고
    • Lipid binding to amyloid β-peptide aggregates: Preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids
    • Avdulov NA, Chochina SV, Igbavboa U, Warden CS, Vassiliev AV, Wood WG (1997): Lipid binding to amyloid β-peptide aggregates: Preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids. J Neurochem 69:1746-1752.
    • (1997) J Neurochem , vol.69 , pp. 1746-1752
    • Avdulov, N.A.1    Chochina, S.V.2    Igbavboa, U.3    Warden, C.S.4    Vassiliev, A.V.5    Wood, W.G.6
  • 2
    • 0030610645 scopus 로고    scopus 로고
    • Microglical activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
    • Barger DW, Harmon AD (1997): Microglical activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878-881.
    • (1997) Nature , vol.388 , pp. 878-881
    • Barger, D.W.1    Harmon, A.D.2
  • 3
    • 0030957196 scopus 로고    scopus 로고
    • Isoform-specific modulation by apolipoprotein e of the activities of secreted β-amyloid precursor protein
    • Barger SW, Mattson MP (1997): Isoform-specific modulation by apolipoprotein E of the activities of secreted β-amyloid precursor protein. J Neurochem 69:60-67.
    • (1997) J Neurochem , vol.69 , pp. 60-67
    • Barger, S.W.1    Mattson, M.P.2
  • 4
    • 0030009670 scopus 로고    scopus 로고
    • Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease
    • Beffert U, Poirier J (1996): Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease. Ann NY Acad Sci 777:166-174.
    • (1996) Ann NY Acad Sci , vol.777 , pp. 166-174
    • Beffert, U.1    Poirier, J.2
  • 5
    • 0028850374 scopus 로고
    • Stable expression and secretion of apolipoprotein E3 and E4 in mouse neuroblastoma cells produce differential effects on neurite outgrowth
    • Bellosta S, Nathan BP, Orth M, Mahley RW, Pitas RE (1995): Stable expression and secretion of apolipoprotein E3 and E4 in mouse neuroblastoma cells produce differential effects on neurite outgrowth. J Biol Chem 270:27063-27071.
    • (1995) J Biol Chem , vol.270 , pp. 27063-27071
    • Bellosta, S.1    Nathan, B.P.2    Orth, M.3    Mahley, R.W.4    Pitas, R.E.5
  • 7
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates α-secretase cleavage of amyloid precursor protein
    • Bodovitz S, Klein WL (1996): Cholesterol modulates α-secretase cleavage of amyloid precursor protein. J Biol Chem 271:4436-4440.
    • (1996) J Biol Chem , vol.271 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.L.2
  • 8
    • 0025149375 scopus 로고
    • Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve
    • Boyles JK, Notterpek LM, Anderson LJ (1990): Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. J Biol Chem 265:17805-17815.
    • (1990) J Biol Chem , vol.265 , pp. 17805-17815
    • Boyles, J.K.1    Notterpek, L.M.2    Anderson, L.J.3
  • 10
    • 0011098182 scopus 로고
    • Spatial distribution of 3-hydroxy-3-methylglutaryl coenzyme a reductase messenger RNA in the ocular lens: Relationship to cholesterogenesis
    • Cenedella RJ, Shi H (1994): Spatial distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase messenger RNA in the ocular lens: Relationship to cholesterogenesis. J Lipid Res 23: 619-626.
    • (1994) J Lipid Res , vol.23 , pp. 619-626
    • Cenedella, R.J.1    Shi, H.2
  • 12
    • 0029958248 scopus 로고    scopus 로고
    • Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
    • Fagan A., Bu G, Sun Y, Daugherty A., Holzman D (1996): Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J Biol Chem 271:30121-30125.
    • (1996) J Biol Chem , vol.271 , pp. 30121-30125
    • Fagan, A.1    Bu, G.2    Sun, Y.3    Daugherty, A.4    Holzman, D.5
  • 13
    • 0025234857 scopus 로고
    • Cholesterol synthesis is down-regulated during regeneration of peripheral nerve
    • Goodrum JF (1990): Cholesterol synthesis is down-regulated during regeneration of peripheral nerve. J Neurochem 54:1709-1715.
    • (1990) J Neurochem , vol.54 , pp. 1709-1715
    • Goodrum, J.F.1
  • 14
    • 0026443801 scopus 로고
    • Effects of apolipoprotein E, β-very low density lipoproteins and cholesterol on the extension of neurites by rabbit dorsal root ganglion neruons in vitro
    • Handelmann GE, Boyles JK, Weisgraber KH, Mahley RW, Pitas RE (1992): Effects of apolipoprotein E, β-very low density lipoproteins and cholesterol on the extension of neurites by rabbit dorsal root ganglion neruons in vitro. J Lipid Res 33:1677-1688.
    • (1992) J Lipid Res , vol.33 , pp. 1677-1688
    • Handelmann, G.E.1    Boyles, J.K.2    Weisgraber, K.H.3    Mahley, R.W.4    Pitas, R.E.5
  • 15
    • 0028822219 scopus 로고
    • Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
    • Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL (1995): Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Aci USA 92:9480-9484.
    • (1995) Proc Natl Acad Aci USA , vol.92 , pp. 9480-9484
    • Holtzman, D.M.1    Pitas, R.E.2    Kilbridge, J.3    Nathan, B.4    Mahley, R.W.5    Bu, G.6    Schwartz, A.L.7
  • 16
    • 0030885417 scopus 로고    scopus 로고
    • Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins
    • Igbavboa U, Avdulov NA, Chochina SV, Wood WG (1997): Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 69:1661-1667.
    • (1997) J Neurochem , vol.69 , pp. 1661-1667
    • Igbavboa, U.1    Avdulov, N.A.2    Chochina, S.V.3    Wood, W.G.4
  • 17
    • 0031963852 scopus 로고    scopus 로고
    • Isoform-specific effect of apolipoprotein e on cell survival and β-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures
    • Jordan J, Galindo MF, Miller RJ., Reardon CA, Getz GS, LaDu MJ (1998): Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. J Neurosci 18:195-204.
    • (1998) J Neurosci , vol.18 , pp. 195-204
    • Jordan, J.1    Galindo, M.F.2    Miller, R.J.3    Reardon, C.A.4    Getz, G.S.5    LaDu, M.J.6
  • 18
    • 0030597061 scopus 로고    scopus 로고
    • Multiple inhibitory effects of Alzheimer's peptide Aβ1-40 on lipid biosynthesis in cultured human HepG2 cells
    • Koudinova NV, Berezov TT, Koudinov AR (1996): Multiple inhibitory effects of Alzheimer's peptide Aβ1-40 on lipid biosynthesis in cultured human HepG2 cells. FEBS Lett 395:204-206.
    • (1996) FEBS Lett , vol.395 , pp. 204-206
    • Koudinova, N.V.1    Berezov, T.T.2    Koudinov, A.R.3
  • 19
    • 0028173205 scopus 로고
    • Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein e promote assembly of Alzheimer β-protein into filaments
    • Ma J, Yee A, Brewer B Jr, Das S, Potter H (1994): Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 372: 92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer Jr., B.3    Das, S.4    Potter, H.5
  • 20
    • 0029832616 scopus 로고    scopus 로고
    • A thrombin cleavage fragment of apolipoprotein e exhibits isoform-specific neurotoxicity
    • Marques MA, Tolar M, Harmony JA, Crutcher KA (1996): A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity. Neuroreport 7:2529-2532.
    • (1996) Neuroreport , vol.7 , pp. 2529-2532
    • Marques, M.A.1    Tolar, M.2    Harmony, J.A.3    Crutcher, K.A.4
  • 21
    • 0030912141 scopus 로고    scopus 로고
    • Apolipoprotein e exhibits isoform-specific neurotoxicity
    • Marques MA Tolar M, Crutcher KA (1997): Apolipoprotein E exhibits isoform-specific neurotoxicity. Alzheimer Res 3:1-6.
    • (1997) Alzheimer Res , vol.3 , pp. 1-6
    • Marques, M.A.1    Tolar, M.2    Crutcher, K.A.3
  • 22
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein e allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
    • Miyata M, Smith JD (1996): Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nature Genet 14:55-61.
    • (1996) Nature Genet , vol.14 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 24
    • 0029157112 scopus 로고
    • The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
    • Nathan BP, Chang KC, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE (1995): The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Biol Chem 270:19791 -19799.
    • (1995) J Biol Chem , vol.270 , pp. 19791-19799
    • Nathan, B.P.1    Chang, K.C.2    Bellosta, S.3    Brisch, E.4    Ge, N.5    Mahley, R.W.6    Pitas, R.E.7
  • 25
    • 0028986690 scopus 로고
    • Apolipoprotein e e4 allele is associated with deposition of amyloid β-protein following head injury
    • Nicoll JAR, Roberts GW , Graham DI (1995): Apolipoprotein E e4 allele is associated with deposition of amyloid β-protein following head injury. Nature Med 1:135-137.
    • (1995) Nature Med , vol.1 , pp. 135-137
    • Nicoll, J.A.R.1    Roberts, G.W.2    Graham, D.I.3
  • 26
    • 0025826774 scopus 로고
    • Astrocytic apolipoprotein e mRNA and GFAP in hippocampus after entorhinal cortex lesioning
    • Poirier J, Hess M, May PC, Finch CE (1991): Astrocytic apolipoprotein E mRNA and GFAP in hippocampus after entorhinal cortex lesioning. Mol Brain Res 11:97-106.
    • (1991) Mol Brain Res , vol.11 , pp. 97-106
    • Poirier, J.1    Hess, M.2    May, P.C.3    Finch, C.E.4
  • 27
    • 0027298061 scopus 로고
    • Cholesterol synthesis and lipoprotein reuptake during synaptic remodeling in hippocampus in adult rats
    • Poirier J, Baccichet A, Dea D, Gauthier S (1993a): Cholesterol synthesis and lipoprotein reuptake during synaptic remodeling in hippocampus in adult rats. Neuroscience 55:81-90.
    • (1993) Neuroscience , vol.55 , pp. 81-90
    • Poirier, J.1    Baccichet, A.2    Dea, D.3    Gauthier, S.4
  • 29
    • 0023269864 scopus 로고
    • Effects of aging on cholesterol content and cholesterol-metabolizing enzymes in the rat adrenal gland
    • Popplewell PY, Azhar S (1987): Effects of aging on cholesterol content and cholesterol-metabolizing enzymes in the rat adrenal gland. Endocrinology 121:64-73.
    • (1987) Endocrinology , vol.121 , pp. 64-73
    • Popplewell, P.Y.1    Azhar, S.2
  • 30
    • 0031013111 scopus 로고    scopus 로고
    • Effect of apolipoprotein e on neurite outgrowth and β-amyloid-induced toxicity in developing rat primary hippocampal cultures
    • Puttfarcken PS, Manelli AM, Falduto MT, Getz GS, LaDu MJ (1997): Effect of apolipoprotein E on neurite outgrowth and β-amyloid-induced toxicity in developing rat primary hippocampal cultures. J Neurochem 68:760-769.
    • (1997) J Neurochem , vol.68 , pp. 760-769
    • Puttfarcken, P.S.1    Manelli, A.M.2    Falduto, M.T.3    Getz, G.S.4    LaDu, M.J.5
  • 32
    • 0027374047 scopus 로고
    • Apolipoprotein e in sporadic Alzheimer's disease: Alelic variation and receptor interactions
    • Rebeck GW, Reiter JS, Strickland DK, Hyman BT (l993): Apolipoprotein E in sporadic Alzheimer's disease: Alelic variation and receptor interactions. Neuron 11:575-580.
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 35
    • 0010731311 scopus 로고
    • Nerve injury stimulates the secretion of apolipoprotein e by nonneuronal cells
    • Snipes GJ, McGuire CB, Norden JJ, Freeman JA (1986): Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells. Proc Natl Acad Sci USA 83:1130-1134.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1130-1134
    • Snipes, G.J.1    McGuire, C.B.2    Norden, J.J.3    Freeman, J.A.4
  • 36
    • 0025736957 scopus 로고
    • Age-related changes in the metabolism of cholesterol in rat liver microsomes
    • Stahlberg D, Angelin B, Einarsson K (1991): Age-related changes in the metabolism of cholesterol in rat liver microsomes. Lipids 26:349-352.
    • (1991) Lipids , vol.26 , pp. 349-352
    • Stahlberg, D.1    Angelin, B.2    Einarsson, K.3
  • 40
    • 0030804828 scopus 로고    scopus 로고
    • Neurotoxicity of thr 22KDa thrombin-cleaved fragments of apolipoprotein e and related synthetic peptide is receptor-mediated
    • Tolar M., Marques MA, Harmony JAK, Crutcher KA (1997): Neurotoxicity of thr 22KDa thrombin-cleaved fragments of apolipoprotein E and related synthetic peptide is receptor-mediated. J Neurosci 17:5678-5686
    • (1997) J Neurosci , vol.17 , pp. 5678-5686
    • Tolar, M.1    Marques, M.A.2    Harmony, J.A.K.3    Crutcher, K.A.4
  • 41
    • 0027970307 scopus 로고
    • Acceleration of Alzheimer's fibril formation by apolipoprotein e in vitro
    • Wisniewski T, Castano EM, Golabek A,Vogel T, Frangione B (1994): Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol 145:1030-1035.
    • (1994) Am J Pathol , vol.145 , pp. 1030-1035
    • Wisniewski, T.1    Castano, E.M.2    Golabek, A.3    Vogel, T.4    Frangione, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.