Adenosine triphosphate-binding cassette subfamily C member 2 is the major transporter of the hepatobiliary imaging agent99mTc-mebrofenin

Journal of Nuclear Medicine

Volumn 50, Issue 7, 2009, Pages 1140-1146

  Bhargava, Kuldeep K ^a,b   Joseph, Brigid ^b,c   Ananthanarayanan, Meenakshisundaram ^d   Balasubramaniyan, Natarajan ^d   Tronco, Gene G ^a,b   Palestro, Christopher J ^a,b   Gupta, Sanjeev ^b,c  

^a North Shore Long Island Health System   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c MARION BESSIN LIVER RESEARCH CENTER   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

99mTc mebrofenin; Canalicular; Gene; Liver; Transport

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE BINDING CASSETTE TRANSPORTER B11; BILIRUBIN; CARBON TETRACHLORIDE; CYCLOSPORIN A; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE INFLAMMATORY PROTEIN 2; MEBROFENIN TC 99M; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MUTANT PROTEIN; PERTECHNETIC ACID TC 99M; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; CELL TRANSPLANTATION; CELL TRANSPORT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG CLEARANCE; DRUG EXCRETION; DRUG LIVER LEVEL; DRUG TRANSPORT; HEPATITIS; HEPATOBILIARY RADIOGRAPHY; KUPFFER CELL; LIVER NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; WESTERN BLOTTING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CARBON TETRACHLORIDE; IMINO ACIDS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; METABOLIC CLEARANCE RATE; ORGANOTECHNETIUM COMPOUNDS; RATS; RATS, INBRED F344; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 67650088551     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.062448     Document Type: Article

References (22)

1. Krishnamurthy GT, Krishnamurthy S. Cholescintigraphic measurement of liver function: how is it different from other methods? Eur J Nucl Med Mol Imaging. 2006;33:1103-1106.
2. Nunn AD, Loberg MD, Conley RA. A structure-distribution-relationship approach leading to the development of Tc-99m mebrofenin: an improved cholescintigraphic agent. J Nucl Med. 1983;24:423-430.
3. Ghibellini G, Leslie EM, Pollack GM, Brouwer KL. Use of Tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. Pharm Res. 2008;25:1851-1860.
4. Planchamp C, Hadengue A, Stieger B, et al. Function of both sinusoidal and canalicular transporters controls the concentration of organic anions within hepatocytes. Mol Pharmacol. 2007;71:1089-1097.
5. Kosters A, Karpen SJ. Bile acid transporters in health and disease. Xenobiotica. 2008;38:1043-1071.
6. Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat Med. 2008;14:828-836.
7. Strautnieks SS, Byrne JA, Pawlikowska L, et al. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology. 2008;134:1203-1214.
8. 99mTc-mebrofenin. Nucl Med Commun. 2008;29:336-344.
9. 99mTc-N-(3-bromo-2,4,6-trimethyacetanilide) iminodiacetic acid liver imaging to assess innate immune responses induced by cell transplantation. Nucl Med Commun. 2009;30:126-133.
10. Paulusma CC, Kool M, Bosma PJ, et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology. 1997;25:1539-1542.
11. Johnson BM, Zhang P, Schuetz JD, Brouwer KL. Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metab Dispos. 2006;34:556-562.
12. Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology. 2002;123:1677-1685.
13. Funk C, Ponelle C, Scheuermann G, Pantze M. Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol. 2001;59:627-635.
14. Wu YM, Joseph B, Gupta S. Immunosuppression using the mTOR inhibition mechanism affects replacement of the rat liver with transplanted cells. Hepatology. 2006;44:410-419.
15. Hesselink DA, van Hest RM, Mathot RA, et al. Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2. Am J Transplant. 2005;5:987-994.
16. Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002;303:273-281.
17. Geier A, Dietrich CG, Voigt S, et al. Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. Am J Physiol Gastrointest Liver Physiol. 2005;289:G831-G841.
18. Siewert E, Dietrich CG, Lammert F, et al. Interleukin-6 regulates hepatic transporters during acute-phase response. Biochem Biophys Res Commun. 2004;322:232-238.
19. Geier A, Dietrich CG, Trauner M, Gartung C. Extrahepatic cholestasis downregulates Oatp1 by TNF-α signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver Int. 2007;27:1056-1065.
20. 99mTc-HIDA cholescintigraphy in Dubin-Johnson and Rotor syndromes. Radiology. 1982;142:743-746.
21. Chu XY, Strauss JR, Mariano MA, et al. Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther. 2006;317:579-589.
22. Joseph B, Bhargava KK, Malhi H, et al. Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes. Eur J Nucl Med. 2003;30:1024-1031.