Immunosuppression using the mTOR inhibition mechanism affects replacement of rat liver with transplanted cells

Hepatology

Volumn 44, Issue 2, 2006, Pages 410-419

  Wu, Yao Ming ^a,b   Joseph, Brigid ^a   Gupta, Sanjeev ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; DIPEPTIDYL PEPTIDASE IV; INOSINATE DEHYDROGENASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; RETRORSINE; TACROLIMUS;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; GENOTOXICITY; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; LIVER; LIVER CELL; LIVER INJURY; LIVER RESECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SURVIVAL TIME; TISSUE GRAFT;

ANIMALS; CELL PROLIFERATION; GRAFT REJECTION; HEPATOCYTES; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; MYCOPHENOLIC ACID; PROTEIN KINASES; RATS; RATS, INBRED F344; RATS, LONG-EVANS; SIROLIMUS; TACROLIMUS;

EID: 33747080541     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21277     Document Type: Article

References (30)

1. Barshes NR, Goodpastor SE, Goss JA. Pharmacologic immunosuppression. Front Biosci 2004;9:411-420.
2. Francavilla A, Starzl TE, Barone M, Zeng QH, Porter KA, Zeevi A, et al. Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506. HEPATOLOGY 1991;14:140-143.
3. Tamura F, Masuhara A, Sakaida I, Fukumoto E, Nakamura T, Okita K. FK506 promotes liver regeneration by suppressing natural killer cell activity. J Gastroenterol Hepatol 1998;13:703-708.
4. Motale P, Mall A, Spearman CW, Lotz Z, Tyler M, Shepherd E, et al. The effect of mycophenolate mofetil on liver regeneration. Transplant Proc 2001;33:1054-1055.
5. Dahmen U, Gu YL, Shen K, Dirsch O, Li J, Fan LM, et al. Onset of liver regeneration after subtotal resection is inhibited by the use of new immunosuppressive drugs. Transplant Proc 2002;34:2312-2313.
6. Nelsen CJ, Rickheim DG, Tucker MM, Hansen LK, Albrecht JH. Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes. J Biol Chem 2003;278:3656-3663.
7. Schumacher G, Oidtmann M, Rueggeberg A, Jacob D, Jonas S, Langrehr JM, et al. Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth. World J Gastroenterol 2005;11:1420-1425.
8. Stallone G, Schena A, Infante B, Di Paolo S, Loverre A, Maggio G, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005;352:1317-1323.
9. Guertin DA, Sabatini DM. An expanding role for mTOR in cancer. Trends Mol Med 2005;11:353-361.
10. Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 2002;123:1677-1685.
11. Yang Z, Chen M, Ellett JD, Carter JD, Brayman KL, Nadler JL. Inflammatory blockade improves human pancreatic islet function and viability. Am J Transplant 2005;5:475-483.
12. Kumaran V, Joseph B, Benten D, Gupta S. Integrin and extracellular matrix interactions regulate engraftment of transplanted hepatocytes in the rat liver. Gastroenterology 2005;129:1643-1653.
13. Laconi E, Oren R, Mukhopadhyay DK, Hurston E, Laconi S, Pani P, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998;153:319-329.
14. Gupta S, Rajvanshi P, Sokhi RP, Slehria S, Yam A, Kerr A, et al. Entry and integration of transplanted hepatocytes in liver plates occur by disruption of hepatic sinusoidal endothelium. HEPATOLOGY 1999;29:509-519.
15. Joseph B, Berishvili E, Benten D, Kumaran V, Liponava E, Bhargava K, et al. Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions. Nat Med 2004;10:749-753.
16. Haddad el-B, McCluskie K, Birrell MA, Dabrowski D, Pecoraro M, Underwood S, et al. Differential effects of ebsden on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide- induced pulmonary inflammation. J Immunol 2002;169:974-982.
17. Valatas V, Kolios G, Manousou P, Notas G, Xidakis C, Diamantis I, et al. Octreotide regulates CC but not CXC LPS-induced chemokine secretion in rat Kupffer cells. Br J Pharmacol 2004;141:477-487.
18. Lin CS, Lin G, Chen KC, Ho HC, Lue TF. Vascular endothelial growth factor induces IP-10 chemokine expression. Biochem Biophys Res Commun 2002;292:79-82.
19. Gupta S, LaBrecque DR, Shafritz DA. Mitogenic effects of hepatic stimulator substance on cultured nonparenchymal liver epithelial cells. HEPATOLOGY 1992;15:485-491.
20. Tian H, Ou J, Strom SC, Venkataramanan R. Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats. Drug Metab Dispos 2005;33:329-335.
21. Vu MD, Qi S, Xu D, Wu J, Fitzsimmons WE, Sehgal SN, et al. Tacrolimus and sirolimus in combination are not antagonistic but produce extended graft survival in cardiac transplantation in rat. Transplantation 1997;64:1853-1856.
22. Bumgardner GL, Orosz CG. Unusual patterns of alloimmunity evoked by allogeneic liver parenchyma cells. Immunol Rev 2000;174:260-279.
23. Jorgensen PF, Wang JE, Almlof M, Solberg R, Okkenhaug C, Scholz T, et al. Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production. Scand J Immunol 2001;53:184-191.
24. Sasakawa Y, Sakuma S, Higashi Y, Sasakawa T, Amaya T, Goto T. FK506 suppresses neutrophil chemoattractant production by peripheral blood mononuclear cells. Eur J Pharmacol 2000;403:281-288.
25. Hackstein H, Taner T, Logar AJ, Thomson AW. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 2002;100:1084-1087.
26. Gomez-Cambronero J. Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Lett 2003;550:94-100.
27. Malhi H, Annamaneni P, Slehria S, Joseph B, Bhargava KK, Palestro CJ, et al. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improved transplanted cell engraftment in rat liver. HEPATOLOGY 2002;36:112-121.
28. Ilyin GP, Glaise D, Gilot D, Baffet G, Guguen-Guillouzo C. Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth. Am J Physiol Gastrointest Liver Physiol 2003;285:G115-G127.
29. Rosner D, McCarthy N, Bennett M. Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53. Cardiovasc Res 2005;66:601-610.
30. Kauffman HM, Cherikh WS, Cheng Y, Hanto DW, Kahan BD. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 2005;80:883-889.