메뉴 건너뛰기




Volumn 146, Issue 2, 2009, Pages 193-202

A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Author keywords

Acute myeloid leukaemia; Flt3 ITD; Gab2; Stat5; Survival

Indexed keywords

CD135 ANTIGEN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT PROTEIN;

EID: 67650001509     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07725.x     Document Type: Article
Times cited : (25)

References (43)
  • 1
    • 4644275694 scopus 로고    scopus 로고
    • Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation
    • Arnaud, M., Crouin, C., Deon, C., Loyaux, D. Bertoglio, J. (2004) Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation. Journal of Immunology, 173, 3962 3971. (Pubitemid 39280760)
    • (2004) Journal of Immunology , vol.173 , Issue.6 , pp. 3962-3971
    • Arnaud, M.1    Crouin, C.2    Deon, C.3    Loyaux, D.4    Bertoglio, J.5
  • 2
    • 0035021881 scopus 로고    scopus 로고
    • Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a
    • DOI 10.1159/000049187
    • Brockdorff, J.L., Gu, H., Mustelin, T., Kaltoft, K., Geisler, C., Röpke, C. Ødum, N. (2001) Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a. Experimental and Clinical Immunogenetics, 18, 86 95. (Pubitemid 32429673)
    • (2001) Experimental and Clinical Immunogenetics , vol.18 , Issue.2 , pp. 86-95
    • Brockdorff, J.L.1    Gu, H.2    Mustelin, T.3    Kaltoft, K.4    Geisler, C.5    Ropke, C.6    Odum, N.7
  • 3
    • 34347207939 scopus 로고    scopus 로고
    • STAT5 signaling in normal and pathologic hematopoiesis
    • Bunting, K.D. (2007) STAT5 signaling in normal and pathologic hematopoiesis. Frontiers in Bioscience, 12, 2807 2820.
    • (2007) Frontiers in Bioscience , vol.12 , pp. 2807-2820
    • Bunting, K.D.1
  • 4
    • 3142703726 scopus 로고    scopus 로고
    • FLT3-activating mutations are associated with poor prognostic features in AML at diagnosis but they are not an independent prognostic factor
    • DOI 10.1038/sj.thj.6200382
    • Chillón, M.C., Fernández, C., García-Sanz, R., Balanzategui, A., Ramos, F., Fernández-Calvo, J., González, M. Miguel, J.F. (2004) FLT3-activating mutations are associated with poor prognostic features in AML at diagnosis but they are not an independent prognostic factor. The Hematology Journal, 5, 239 246. (Pubitemid 38931330)
    • (2004) Hematology Journal , vol.5 , Issue.3 , pp. 239-246
    • Chillon, M.C.1    Fernandez, C.2    Garcia-Sanz, R.3    Balanzategui, A.4    Ramos, F.5    Fernandez-Calvo, J.6    Gonzalez, M.7    San Miquel, J.F.8
  • 5
    • 0032525115 scopus 로고    scopus 로고
    • Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway
    • Chin, H., Arai, A., Wakao, H., Kamiyama, R., Miyasaka, N. Miura, O. (1998) Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Blood, 91, 3734 3745. (Pubitemid 28225741)
    • (1998) Blood , vol.91 , Issue.10 , pp. 3734-3745
    • Chin, H.1    Arai, A.2    Wakao, H.3    Kamiyama, R.4    Miyasaka, N.5    Miura, O.6
  • 6
    • 22044448746 scopus 로고    scopus 로고
    • AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
    • DOI 10.1182/blood-2004-07-2942
    • Choudhary, C., Schwäble, J., Brandts, C., Tickenbrock, L., Sargin, B., Kindler, T., Fischer, T., Berdel, W.E., Müller-Tidow, C. Serve, H. (2005) AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood, 106, 265 273. (Pubitemid 40967202)
    • (2005) Blood , vol.106 , Issue.1 , pp. 265-273
    • Choudhary, C.1    Schwable, J.2    Brandts, C.3    Tickenbrock, L.4    Sargin, B.5    Kindler, T.6    Fischer, T.7    Berdel, W.E.8    Muller-Tidow, C.9    Serve, H.10
  • 9
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • DOI 10.1182/blood-2002-02-0492
    • Gilliland, D.G. Griffin, J.D. (2002) The roles of FLT3 in hematopoiesis and leukemia. Blood, 100, 1532 1542. (Pubitemid 34925124)
    • (2002) Blood , vol.100 , Issue.5 , pp. 1532-1542
    • Gary Gilliland, D.1    Griffin, J.D.2
  • 10
    • 0842310394 scopus 로고    scopus 로고
    • The Structural Basis for Autoinhibition of FLT3 by the Juxtamembrane Domain
    • DOI 10.1016/S1097-2765(03)00505-7
    • Griffith, J., Black, J., Faerman, C., Swenson, L., Wynn, M., Lu, F., Lippke, J. Saxena, K. (2004) The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Molecular Cell, 13, 169 178. (Pubitemid 38183264)
    • (2004) Molecular Cell , vol.13 , Issue.2 , pp. 169-178
    • Griffith, J.1    Black, J.2    Faerman, C.3    Swenson, L.4    Wynn, M.5    Lu, F.6    Lippke, J.7    Saxena, K.8
  • 12
    • 34347207060 scopus 로고    scopus 로고
    • SFK-STAT pathway: An alternative and important way to malignancies
    • DOI 10.1196/annals.1377.002, Integrated Molecular Medicine for Neuronal and Neoplastic Disorders
    • Hayakawa, F. Naoe, T. (2006) SFK-STAT pathway: an alternative and important way to malignancies. Annals of the New York Academy of Sciences, 1086, 213 222. (Pubitemid 47084370)
    • (2006) Annals of the New York Academy of Sciences , vol.1086 , pp. 213-222
    • Hayakawa, F.1    Naoe, T.2
  • 13
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa, F., Towatari, M., Kiyoi, H., Tanimoto, M., Kitamura, T., Saito, H. Naoe, T. (2000) Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene, 19, 624 631. (Pubitemid 30102913)
    • (2000) Oncogene , vol.19 , Issue.5 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6    Naoe, T.7
  • 14
    • 33748192963 scopus 로고    scopus 로고
    • Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2
    • DOI 10.1182/blood-2005-07-008896
    • Heiss, E., Masson, K., Sundberg, C., Pedersen, M., Sun, J., Bengtsson, S. Rönnstrand, L. (2006) Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. Blood, 108, 1542 1550. (Pubitemid 44316119)
    • (2006) Blood , vol.108 , Issue.5 , pp. 1542-1550
    • Heiss, E.1    Masson, K.2    Sundberg, C.3    Pedersen, M.4    Sun, J.5    Bengtsson, S.6    Ronnstrand, L.7
  • 17
    • 0037061747 scopus 로고    scopus 로고
    • Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    • DOI 10.1038/sj/onc/1205332
    • Kiyoi, H., Ohno, R., Ueda, R., Saito, H. Naoe, T. (2002) Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. Oncogene, 21, 2555 2563. (Pubitemid 34438108)
    • (2002) Oncogene , vol.21 , Issue.16 , pp. 2555-2563
    • Kiyoi, H.1    Ohno, R.2    Ueda, R.3    Saito, H.4    Naoe, T.5
  • 18
    • 0034680848 scopus 로고    scopus 로고
    • Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis: Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes
    • DOI 10.1074/jbc.M005621200
    • Kong, M., Mounier, C., Wu, J. Posner, B.I. (2000) Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. Journal of Biological Chemistry, 275, 36035 36042. (Pubitemid 30841147)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.46 , pp. 36035-36042
    • Kong, M.1    Mounier, C.2    Wu, J.3    Posner, B.I.4
  • 19
    • 0033619142 scopus 로고    scopus 로고
    • Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction
    • DOI 10.1038/sj.onc.1202929
    • Lennartsson, J., Blume-Jensen, P., Hermanson, M., Pontén, E., Carlberg, M. Rönnstrand, L. (1999) Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction. Oncogene, 18, 5546 5553. (Pubitemid 29481501)
    • (1999) Oncogene , vol.18 , Issue.40 , pp. 5546-5553
    • Lennartsson, J.1    Blume-Jensen, P.2    Hermanson, M.3    Ponten, E.4    Carlberg, M.5    Ronnstrand, L.6
  • 20
    • 0035044042 scopus 로고    scopus 로고
    • Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase
    • DOI 10.1128/MCB.21.9.3047-3056.2001
    • Liu, Y., Jenkins, B., Shin, J.L. Rohrschneider, L.R. (2001) Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase. Molecular and Cellular Biology, 21, 3047 3056. (Pubitemid 32298372)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.9 , pp. 3047-3056
    • Liu, Y.1    Jenkins, B.2    Jun Lim Shin3    Rohrschneider, L.R.4
  • 21
    • 0027461751 scopus 로고
    • Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase
    • Maroc, N., Rottapel, R., Rosnet, O., Marchetto, S., Lavezzi, C., Mannoni, P., Birnbaum, D. Dubreuil, P. (1993) Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase. Oncogene, 8, 909 918.
    • (1993) Oncogene , vol.8 , pp. 909-918
    • Maroc, N.1    Rottapel, R.2    Rosnet, O.3    Marchetto, S.4    Lavezzi, C.5    Mannoni, P.6    Birnbaum, D.7    Dubreuil, P.8
  • 22
    • 0141958305 scopus 로고    scopus 로고
    • Different antiapoptotic pathways between wild-type and mutated FLT3: Insights into therapeutic targets in leukemia
    • DOI 10.1182/blood-2002-12-3813
    • Minami, Y., Yamamoto, K., Kiyoi, H., Ueda, R., Saito, H. Naoe, T. (2003) Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. Blood, 102, 2969 2975. (Pubitemid 37248872)
    • (2003) Blood , vol.102 , Issue.8 , pp. 2969-2975
    • Minami, Y.1    Yamamoto, K.2    Kiyoi, H.3    Ueda, R.4    Saito, H.5    Naoe, T.6
  • 25
    • 34248224915 scopus 로고    scopus 로고
    • A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to friend virus infection
    • DOI 10.1128/MCB.01838-06
    • Ni, S., Zhao, C., Feng, G.S., Paulson, R.F. Correll, P.H. (2007) A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Molecular and Cellular Biology, 27, 3708 3715. (Pubitemid 46726178)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.10 , pp. 3708-3715
    • Ni, S.1    Zhao, C.2    Feng, G.-S.3    Paulson, R.F.4    Correll, P.H.5
  • 26
    • 0033199236 scopus 로고    scopus 로고
    • STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
    • DOI 10.1093/emboj/18.17.4754
    • Nosaka, T., Kawashima, T., Misawa, K., Ikuta, K., Mui, A.L. Kitamura, T. (1999) STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO Journal, 18, 4754 4765. (Pubitemid 29415529)
    • (1999) EMBO Journal , vol.18 , Issue.17 , pp. 4754-4765
    • Nosaka, T.1    Kawashima, T.2    Misawa, K.3    Ikuta, K.4    Mui, A.L.-F.5    Kitamura, T.6
  • 27
    • 23944477884 scopus 로고    scopus 로고
    • Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter
    • DOI 10.1042/BJ20041523
    • Nyga, R., Pecquet, C., Harir, N., Gu, H., Dhennin-Duthille, I., Regnier, A., Gouilleux-Gruart, V., Lassoued, K. Gouilleux, F. (2005) Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter. Biochemical Journal, 390, 359 366. (Pubitemid 41192263)
    • (2005) Biochemical Journal , vol.390 , Issue.1 , pp. 359-366
    • Nyga, R.1    Pecquet, C.2    Harir, N.3    Gu, H.4    Dhennin-Duthille, I.5    Regnier, A.6    Gouilleux-Gruart, V.7    Lassoued, K.8    Gouilleux, F.9
  • 28
    • 33747189188 scopus 로고    scopus 로고
    • Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
    • DOI 10.1182/blood-2005-11-011429
    • Rocnik, J.L., Okabe, R., Yu, J.C., Lee, B.H., Giese, N., Schenkein, D.P. Gilliland, D.G. (2006) Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. Blood, 108, 1339 1345. (Pubitemid 44232034)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1339-1345
    • Rocnik, J.L.1    Okabe, R.2    Yu, J.-C.3    Lee, B.H.4    Giese, N.5    Schenkein, D.P.6    Gilliland, D.G.7
  • 29
    • 0034708086 scopus 로고    scopus 로고
    • Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line
    • Rosa Santos, S.C., Dumon, S., Mayeux, P., Gisselbrecht, S. Gouilleux, F. (2000) Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line. Oncogene, 19, 1164 1172. (Pubitemid 30157546)
    • (2000) Oncogene , vol.19 , Issue.9 , pp. 1164-1172
    • Santos, S.C.R.1    Dumon, S.2    Mayeux, P.3    Gisselbrecht, S.4    Gouilleux, F.5
  • 30
    • 0035912097 scopus 로고    scopus 로고
    • Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase/Akt dependent pathway
    • DOI 10.1038/sj.onc.1204308
    • Santos, S.C., Lacronique, V., Bouchaert, I., Monni, R., Bernard, O., Gisselbrecht, S. Gouilleux, F. (2001) Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase/Akt dependent pathway. Oncogene, 20, 2080 2090. (Pubitemid 32424002)
    • (2001) Oncogene , vol.20 , Issue.17 , pp. 2080-2090
    • Santos, S.C.R.1    Lacronique, V.2    Bouchaert, I.3    Monni, R.4    Bernard, O.5    Gisselbrecht, S.6    Gouilleux, F.7
  • 33
    • 0037838661 scopus 로고    scopus 로고
    • Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
    • Spiekermann, K., Bagrintseva, K., Schwab, R., Schmieja, K. Hiddemann, W. (2003) Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clinical Cancer Research, 9, 2140 2150. (Pubitemid 36687636)
    • (2003) Clinical Cancer Research , vol.9 , Issue.6 , pp. 2140-2150
    • Spiekermann, K.1    Bagrintseva, K.2    Schwab, R.3    Schmieja, K.4    Hiddemann, W.5
  • 34
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt, D.L. Radich, J.P. (2003) The role of FLT3 in haematopoietic malignancies. Nature Reviews. Cancer, 3, 650 665. (Pubitemid 37328820)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.9 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 35
    • 35248849299 scopus 로고    scopus 로고
    • Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl
    • DOI 10.1016/j.yexcr.2007.08.021, PII S0014482707004065
    • Sun, J., Pedersen, M., Bengtsson, S. Rönnstrand, L. (2007) Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Experimental Cell Research, 313, 3935 3942. (Pubitemid 47561898)
    • (2007) Experimental Cell Research , vol.313 , Issue.18 , pp. 3935-3942
    • Sun, J.1    Pedersen, M.2    Bengtsson, S.3    Ronnstrand, L.4
  • 36
    • 55549092077 scopus 로고    scopus 로고
    • Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
    • Sun, J., Pedersen, M. Rönnstrand, L. (2008) Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. Journal of Biological Chemistry, 283, 27444 27451.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 27444-27451
    • Sun, J.1    Pedersen, M.2    Rönnstrand, L.3
  • 38
    • 23744444913 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis
    • DOI 10.1038/sj.leu.2403838
    • Yanada, M., Matsuo, K., Suzuki, T., Kiyoi, H. Naoe, T. (2005) Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. Leukemia, 19, 1345 1349. (Pubitemid 41136326)
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1345-1349
    • Yanada, M.1    Matsuo, K.2    Suzuki, T.3    Kiyoi, H.4    Naoe, T.5
  • 40
    • 0033582304 scopus 로고    scopus 로고
    • p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells
    • DOI 10.1006/bbrc.1998.9959
    • Zhang, S. Broxmeyer, H.E. (1999) p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells. Biochemical and Biophysical Research Communications, 254, 440 445. (Pubitemid 29290419)
    • (1999) Biochemical and Biophysical Research Communications , vol.254 , Issue.2 , pp. 440-445
    • Zhang, S.1    Broxmeyer, H.E.2
  • 41
    • 0034649210 scopus 로고    scopus 로고
    • Flt3 ligand induces tyrosine phosphorylation of Gab1 and Gab2 and their association with Shp-2, Grb2, and PI3 kinase
    • DOI 10.1006/bbrc.2000.3662
    • Zhang, S. Broxmeyer, H.E. (2000) Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. Biochemical and Biophysical Research Communications, 277, 195 199. (Pubitemid 30796361)
    • (2000) Biochemical and Biophysical Research Communications , vol.277 , Issue.1 , pp. 195-199
    • Zhang, S.1    Broxmeyer, H.E.2
  • 42
    • 0033020705 scopus 로고    scopus 로고
    • Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
    • Zhang, S., Mantel, C. Broxmeyer, H.E. (1999) Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. Journal of Leukocyte Biology, 65, 372 380. (Pubitemid 29109711)
    • (1999) Journal of Leukocyte Biology , vol.65 , Issue.3 , pp. 372-380
    • Zhang, S.1    Mantel, C.2    Broxmeyer, H.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.