Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols

Journal of Medicinal Chemistry

Volumn 52, Issue 13, 2009, Pages 4007-4019

  Carvalho, João F S ^a   Cruz Silva, M Manuel ^a   Moreira, João N ^a,b   Simões, Sérgio ^a,b   Sá E Melo, M Luisa ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA HYDROXY 5BETA,6BETA EPOXYCHOLESTAN 4BETA YLACETATE; 4ALPHA,5ALPHA EPOXYCHOLESTAN 3BETA OL; 4BETA HYDROXY 5BETA,6BETA EPOXYCHOLESTAN 3BETA YLACETATE; 4BETA,5BETA EPOXYCHOLESTAN 3BETA OL; 4BETA,5BETA EPOXYCHOLESTAN 3BETA YLACETATE; 5ALPHA,6ALPHA EPOXY 7 NORCHOLESTAN 3BETA OL; 5ALPHA,6ALPHA EPOXYCHOLESTANE 3BETA,4BETA DIOL; 5ALPHA,6ALPHA EPOXYCHOLESTANE 3BETA,7ALPHA DIOL; 5ALPHA,6ALPHA EPOXYCHOLESTANE 3BETA,7BETA DIOL; 5BETA,6BETA EPOXYCHOLESTAN 3BETA OL; 5BETA,6BETA EPOXYCHOLESTANE 3BETA,4BETA DIOL; 5BETA,6BETA EPOXYCHOLESTANE 3BETA,7BETA DIOL; 7ALPHA HYDROXYCHOLESTEROL; 7BETA HYDROXYCHOLEST 5 EN 3BETA YLACETATE; 7BETA HYDROXYCHOLESTEROL; ACETONITRILE; ANTINEOPLASTIC AGENT; CHOLEST 5 ENE 3BETA,4BETA DIOL; CHOLESTEROL 5ALPHA,6ALPHA OXIDE; CHOLESTEROL DERIVATIVE; CISPLATIN; DOXORUBICIN; EPOXIDE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HT29; CONTROLLED STUDY; CYTOTOXICITY; DEACETYLATION; DIASTEREOISOMER; DRUG SYNTHESIS; ESTERIFICATION; HUMAN; HUMAN CELL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; HUMANS; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649968077     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9003973     Document Type: Article

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