Improved synthesis and molecular modeling of 4β,19-dihydroxyandrost-5- en-17-one, an excellent inhibitor of aromatase

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 5, 2002, Pages 703-705

  Numazawa, Mitsuteru ^a   Yamada, Keiko ^a   Watari, Yoko ^a   Ando, Momoko ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

4 ,19 dihydroxyandrost 5 en 17 one; Aromatase inhibitor; Molecular modeling; PM3 method; Synthesis

Indexed keywords

19 (TERT BUTYLDIMETHYLSILYLOXY)ANDROST 4 EN 17 ONE; 3 CHLOROPERBENZOIC ACID; 4BETA,19 DIHYDROXYANDROST 5 EN 17 ONE; ACETOACETIC ACID DERIVATIVE; ALCOHOL DERIVATIVE; AROMATASE INHIBITOR; BENZOIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 4,19 DIHYDROXYANDROST 5 EN 17 ONE; 4,19-DIHYDROXYANDROST-5-EN-17-ONE; ANDROSTANE DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DEHYDRATION; DRUG SYNTHESIS; ENERGY; HYDROLYSIS; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; CHEMICAL STRUCTURE; INFRARED SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANDROSTENES; AROMATASE INHIBITORS; ENZYME INHIBITORS; HYDROLYSIS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036579852     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.703     Document Type: Article

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