Comparison of the apoptotic processes induced by the oxysterols 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide

Cell Biology and Toxicology

Volumn 20, Issue 5, 2004, Pages 313-323

  Ryan, L ^a   O'Callaghan, Y C ^a   O'Brien, N M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

7 hydroxycholesterol; Antioxidants; Apoptosis; Cholesterol 5 ,6 epoxide; U937 cells

Indexed keywords

7BETA HYDROXYCHOLESTEROL; ANTIOXIDANT; APOPTOSIS INHIBITOR; CASPASE 3 INHIBITOR; CASPASE INHIBITOR; CHOLESTEROL 5BETA,6BETA OXIDE; CYTOCHROME C; EBSELEN; GLUTATHIONE; OXYSTEROL; PROTEIN INHIBITOR; RESVERATROL; TROLOX C; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; CELL SURVIVAL; CHOLESTEROL; DNA FRAGMENTATION; GLUTATHIONE; HUMANS; HYDROXYCHOLESTEROLS; SIGNAL TRANSDUCTION;

EID: 17644424665     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10565-004-5066-7     Document Type: Article

References (40)

1. Albertini R, Abuja PM. Prooxidant and antioxidant properties of Trolox C, analogue of vitamin E, in oxidation of low-density lipoprotein. Free Radic Res. 1999;30:181-8.
2. Aratri E, Spycher SE, Breyer I, Azzi A. Modulation of alpha-tropomyosin expression by alpha-tocopherol in rat smooth muscle cells. FEBS Lett. 1999;447:91-4.
3. Arteel GE, Sies H. The biochemistry of selenium and the glutathione system. Environ Toxicol Phar. 2001;10:153-8.
4. Ashe PC, Berry MD. Apoptotic signalling cascades. Prog Neuro-Psychoph. 2003;27:199-214.
5. Aupeix K, Weltin D, Mejia, JE, et al. Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiology. 1995;194:415-28.
6. Azzi A, Stocker A. Vitamin E: non-antioxidant roles. Prog Lipid Res. 2000;39:231-55.
7. Biasi F, Leonarduzzi G, Vizio B, et al. Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation. FASEB J. 2004;18:693-5.
8. Boscoboinik D, Szewczyk A, Hensey C, Azzi A. Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. J Biol Chem. 1991;266:6188-94.
9. Cain K, Bratton SB, Cohen GM. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie. 2002;84:203-14.
10. Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med. 2000;29:323-33.
11. Christ M, Luu B, Mejia JE, Moosbrugger I, Bischoff P. Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes. Immunology. 1993;78:455-60.
12. Coppola S, Ghibelli L. GSH extrusion and the mitochondrial pathway of apoptotic signalling. Biochem Soc Trans. 2000;28:56-61.
13. Custodio JBA, Cardoso CMP, Almeida LM. Thiol protecting agents and antioxidants inhibit the mitochondrial permeability transition promoted by etoposide: implications in the prevention of etoposide-induced apoptosis. Chem-Biol Interact. 2002;140:169-84.
14. Dubrez L, Savoy I, Hamman A, Solary E. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fasmediated apoptotic pathways. EMBO J. 1996;15:5504-12.
15. Gregorio-King CC, Gough T, Van Der Meer GJ, et al. Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. J Steroid Biochem Mol Biol. 2004;88:311-20.
16. Harada-Shiba M, Kinoshita M, Kamido H, Shimokado K. Oxidised low-density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. J Biol Chem. 1998;273:9681-7.
17. Huigsloot M, Tijdens IB, Mulder GJ, van de Water B. Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells. Biochem Pharmacol. 2001;62:1087-97.
18. Kiechle FL, Zhang X. Apoptosis: biochemical aspects and clinical implications. Clin Chim Acta. 2002;326:27-45.
19. Lee T-S, Chau L-Y. Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. Am J Physiol-Cell Ph. 2001;280:C709-18.
20. Leonard SS, Xia C, Jiang B-H, et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Comm. 2003;309:1017-26.
21. Li W, Dalen H, Eaton JW, Yuan XM. Apoptotic death of inflammatory cells in human atheroma. Arterioscler Thromb Vasc Biol. 2001;21:1124-1130.
22. Lim H-K, Kang H-K, Yoo E-S, et al. Oxysterols induce apoptosis and accumulation of cell cycle at G2/M phase in the human monocytic THP-1 cell line. Life Sci. 2003;72:1389-99.
23. Lizard G, Miguet C, Bessede G, et al. Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occurring during 7-ketocholesterol-induced apoptosis. Free Radic Biol Med. 2000;28:743-56.
24. Lizard G, Monier S, Cordelet C, et al. Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7β-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. Arterioscler Thromb Vasc Biol. 1999;19:1190-200.
25. Lyons NM, Woods JA, O'Brien NM. α-Tocopherol, but not γ-tocopherol inhibits 7β-hydroxycholesterol-induced apoptosis in human U937 cells. Free Radic Res. 2001;35:329-39.
26. Miguet C, Monier S, Bettiaeb A, et al. Ceramide generation occurring during 7β-hydroxycholesterol and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. Cell Death Differ. 2001;8:83-99.
27. Miguet-Alfonsi C, Prunet C, Monier S, et al. Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7β-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. Biochem Pharmacol. 2002;64:527-41.
28. Mowels JM. Mycoplasma detection. In: Pollard JW and Walker JM, eds. Methods in molecular biology. Volume V, Animal cell culture. Humana Press, Clifton, NJ. 1990:65-74.
29. O'Callaghan YC, Woods JA, O'Brien NM. Characteristics of 7β-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937 and a human hepatoma cell line, HepG2. Toxicol In Vitro. 2002;16:245-51.
30. O'Callaghan YC, Woods JA, O'Brien NM. Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. Cell Biol Toxicol. 2001;17:127-37.
31. O'Callaghan YC, Woods JA, O'Brien NM. Limitations of the single-cell gel electrophoresis assay to monitor apoptosis in U937 and HepG2 cells exposed to 7β-hydroxycholesterol. Biochem Pharmacol. 2001;61:1217-26.
32. O'Callaghan YC, Woods JA, O'Brien NM. Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. Eur J Nutr. 1999;38:255-62.
33. Panini SR, Sinensky MS. Mechanisms of oxysterol-induced apoptosis. Curr Opin Lipidol. 2001;12:529-33.
34. Rimbach G, Minihane AM, Majewicz J, et al. Regulation of cell signalling by vitamin E. Proc Nutr Soc. 2002;61:415-25.
35. Ryan L, O'Callaghan YC, O'Brien NM. Generation of an oxidative stress precedes caspase activation during 7 aβ-hydroxycholesterol-induced apoptosis. J Biochem Mol Toxicol. 2004;18:50-9.
36. Salvayre R, Auge N, Benoist H, Negre-Salvayre A. Oxidised low-density lipoprotein-induced apoptosis. Biochem Biophys Acta. 2002;55989:1-9.
37. Smith PK, Krohn RI, Hermanson GT, et al. Measurement of protein using bicinchoninic acid. Anal Biochem. 1985;150: 76-85.
38. Strauss GHS. Non-random cell killing in cryopreservation: implications for performance of the battery of leukocyte tests (BLT), I. Toxic and immunotoxic effects. Mutat Res. 1991;252:1-15.
39. Thorburn A. Death receptor-induced cell killing. Cell Signal. 2004;16:139-44.
40. Uemura M, Manabe H, Yoshida N, et al. Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. Eur J Pharmacol. 2002;456:29-37.