Crystal structure of a trypanocidal 4,4′-bis(imidazolinylamino) diphenylamine bound to DNA

Biochemistry

Volumn 48, Issue 25, 2009, Pages 5943-5952

  Glass, LaTeca S ^a   Nguyen, Binh ^b   Goodwin, Kristie D ^a   Dardonville, Christophe ^c   Wilson, W David ^b   Long, Eric C ^a   Georgiadis, Millie M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIFURCATED HYDROGEN BONDS; CONFORMATIONAL CHANGE; DNA BINDING SITE; FURTHER DEVELOPMENT; HOST-GUEST; INDUCED FIT; MINOR GROOVES; SITE SELECTIVITY; SMALL MOLECULES; VAN DER WAALS INTERACTIONS;

ANILINE; BINDING ENERGY; BINDING SITES; DNA; GENES; HYDROGEN; HYDROGEN BONDS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; VAN DER WAALS FORCES;

CRYSTAL STRUCTURE;

4,4' BIS(GUANIDINO)DIPHENYLAMINE; 4,4' BIS(IMIDAZOLINYLAMINO)DIPHENYLAMINE; ANTITRYPANOSOMAL AGENT; CD27 ANTIGEN; DNA; INTERLEUKIN 2 RECEPTOR ALPHA; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DNA BINDING; DRUG PROTEIN BINDING; DRUG STRUCTURE; PRIORITY JOURNAL;

ANIMALS; BENZAMIDINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPHENYLAMINE; DNA; IMIDAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA;

EID: 67649607258     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900204w     Document Type: Article

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