DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity

Journal of Medicinal Chemistry

Volumn 49, Issue 12, 2006, Pages 3748-3752

  Dardonville, Christophe ^a   Barrett, Michael P ^b   Brun, Reto ^c   Kaiser, Marcel ^c   Tanious, Farial ^d   Wilson, W David ^d  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITRYPANOSOMAL AGENT; DIMINAZENE; DIMINAZENE ACETURATE; GUANIDINE DERIVATIVE; IMIDAZOLINE DERIVATIVE; PENTAMIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DNA BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; FEMALE; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SURVIVAL; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ANIMALS; DNA; FEMALE; GUANIDINES; IMIDAZOLINES; MICE; NUCLEOSIDE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 33745122945     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060295c     Document Type: Article

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