Crystal structure of DNA-bound Co(III)·bleomycin B2: Insights on intercalation and minor groove binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 13, 2008, Pages 5052-5056

  Goodwin, Kristie D ^a   Lewis, Mark A ^b   Long, Eric C ^b   Georgiadis, Millie M ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Antitumor; DNA binding; HOO Co(III) bleomycin

Indexed keywords

2,3 DIAMINOPROPIONIC ACID; BLEOMYCIN B2; COBALT; DISACCHARIDE; HISTIDINE; HYDROPEROXIDE; IMIDAZOLE; OLIGONUCLEOTIDE; PYRIMIDINE; THREONINE; BLEOMYCIN; CROSS LINKING REAGENT; DNA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA DAMAGE; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BLEOMYCIN; COBALT; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; DISACCHARIDES; DNA; MODELS, MOLECULAR; MOLECULAR CONFORMATION;

EID: 42449157091     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708143105     Document Type: Article

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