Liver development: Lessons from knockout mice and mutant fish

Hepatology Research

Volumn 39, Issue 7, 2009, Pages 633-644

  Nakamura, Takashi ^a   Nishina, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Antibody; Knockout mice; Liver development; Medaka; Zebrafish

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CCAAT ENHANCER BINDING PROTEIN ALPHA; FIBROBLAST GROWTH FACTOR; HEPATOCYTE NUCLEAR FACTOR 6; HERMES ANTIGEN; HOMEODOMAIN PROTEIN; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; K RAS PROTEIN; MATRIX METALLOPROTEINASE 14; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; PROTEIN HHEX; SCATTER FACTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HLX; TRANSCRIPTION FACTOR PIK3R1; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR TBK1; TRANSCRIPTION FACTOR TBX3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; BILE DUCT; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; FISH; KNOCKOUT MOUSE; LIVER CELL; LIVER DEVELOPMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW;

EID: 67649595551     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2009.00522.x     Document Type: Review

References (51)

1. Zaret KS. Regulatory phases of early liver development: Paradigms of organogenesis. Nat Rev Genet 2002; 3: 499-512.
2. Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008; 5 (322): 1490-4.
3. Zaret KS. Genetic programming of liver and pancreas progenitors: Lessons for stem-cell differentiation. Nat Rev Genet 2008; 9: 329-40.
4. Jung J, Zheng M, Goldfarb M, Zaret KS. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 1999; 18 (284): 1998-2003.
5. Douarin NM. An experimental analysis of liver development. Med Biol 1975; 53: 427-55.
6. Houssaint E. Differentiation of the mouse hepatic primordium. I. An analysis of tissue interactions in hepatocyte differentiation. Cell Differ 1980; 9: 269-79.
7. Rossi JM, Dunn NR, Hogan BL, Zaret KS. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev 2001; 1: 1998-2009.
8. Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2004; 131: 797-806.
9. Martinez Barbera JP, Clements M, Thomas P et al. The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development 2000; 127: 2433-45.
10. Thomas PQ, Brown A, Beddington RS. Hex: A homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 1998; 125: 85-94.
11. Hunter MP, Wilson CM, Jiang X et al. The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol 2007; 15 (308): 355-67.
12. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995; 13 (376): 167-70.
13. Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999; 9 (284): 321-5.
14. Li ZW, Chu W, Hu Y et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999; 7 (189): 1839-45.
15. Tanaka M, Fuentes ME, Yamaguchi K et al. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immun 1999; 10: 421-9.
16. Rudolph D, Yeh WC, Wakeham A et al. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev 2000; 1 (14): 854-62.
17. Bonnard M, Mirtsos C, Suzuki S et al. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J 2000; 15 (19): 4976-85.
18. Fruman DA, Mauvais-Jarvis F, Pollard DA et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet 2000; 26: 379-82.
19. Ganiatsas S, Kwee L, Fujiwara Y et al. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci USA 1998; 9 (95): 6881-6.
20. Nishina H, Bachmann M, Oliveira-dos-Santos AJ et al. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med 1997; 15 (186): 941-53.
21. Nishina H, Fischer KD, Radvanyi L et al. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 1997; 23 (385): 350-3.
22. Nishina H, Vaz C, Billia P et al. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 1999; 126: 505-16.
23. Yang D, Tournier C, Wysk M et al. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci USA 1997; 1 (94): 3004-9.
24. Hilberg F, Aguzzi A, Howells N, Wagner EF. c-jun is essential for normal mouse development and hepatogenesis. Nature 1993; 9 (365): 179-81.
25. Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev 1993; 7: 1309-17.
26. Wada T, Joza N, Cheng HY et al. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol 2004; 6: 215-26.
27. Davenport TG, Jerome-Majewska LA, Papaioannou VE. Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development 2003; 130: 2263-73.
28. Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H. Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19 ARF expression. Development 2008; 135: 1589-95.
29. Zhao R, Duncan SA. Embryonic development of the liver. Hepatology 2005; 41: 956-67.
30. Field HA, Ober EA, Roeser T, Stainier DY. Formation of the digestive system in zebrafish. I. Liver morphogenesis. Dev Biol 2003; 15 (253): 279-90.
31. Ober EA, Verkade H, Field HA, Stainier DY. Mesodermal Wnt2b signaling positively regulates liver specification. Nature 2006; 10 (442): 688-91.
32. Sakaguchi TF, Sadler KC, Crosnier C, Stainier DY. Endothelial signals modulate hepatocyte apicobasal polarization in zebrafish. Curr Biol 2008; 28 (18): 1565-71.
33. Watanabe T, Asaka S, Kitagawa D et al. Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria. Mech Dev 2004; 121: 791-802.
34. Matsumoto T, Terai S, Kuwashiro S et al. The Development of new drug screening system using steatohepatitis Medaka fish model induced by high fat diet. Hepatology 2007; 46 (4 Suppl 1): 756A.
35. Shiojiri N. Enzymo- and immunocytochemical analyses of the differentiation of liver cells in the prenatal mouse. J Embryol Exp Morphol 1981; 62: 139-52.
36. Murakami T, Yasuda Y, Mita S et al. Prealbumin gene expression during mouse development studied by in situ hybridization. Cell Differ 1987; 22: 1-9.
37. Tilghman SM, Belayew A. Transcriptional control of the murine albumin/ alpha-fetoprotein locus during development. Proc Natl Acad Sci USA 1982; 79: 5254-7.
38. Tanimizu N, Nishikawa M, Saito H, Tsujimura T, Miyajima A. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 2003; 1 (116): 1775-86.
39. Tanimizu N, Tsujimura T, Takahide K, Kodama T, Nakamura K, Miyajima A. Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver. Gene Expr Patterns 2004; 5: 209-18.
40. Moon YS, Smas CM, Lee K et al. Mice lacking paternally expressed Pref-1/ Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol 2002; 22: 5585-92.
41. Watanabe T, Nakagawa K, Ohata S et al. SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. Dev Biol 2002; 15 (250): 332-47.
42. Ishikawa T, Terai S, Urata Y et al. Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res 2006; 323: 221-31.
43. Nierhoff D, Ogawa A, Oertel M, Chen YQ, Shafritz DA. Purification and characterization of mouse fetal liver epithelial cells with high in vivo repopulation capacity. Hepatology 2005; 42: 130-9.
44. Suzuki T, Kanai Y, Hara T et al. Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol 2006; 26: 6149-56.
45. Sakaida I, Terai S, Yamamoto N et al. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 2004; 40: 1304-11.
46. Yamamoto N, Terai S, Ohata S et al. A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver. Biochem Biophys Res Commun 2004; 23 (313): 1110-8.
47. Ohata S, Nawa M, Kasama T et al. Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. Biochem Biophys Res Commun 2009; 20 (379): 817-23.
48. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990; 29 (61): 1303-13.
49. Ponta H, Sherman L, Herrlich PA. CD44: From adhesion molecules to signaling regulators. Nat Rev Mol Cell Biol 2003; 4: 33-45.
50. Kon J, Ooe H, Oshima H, Kikkawa Y, Mitaka T. Expression of CD44 in rat hepatic progenitor cells. J Hepatol 2006; 45: 90-8.
51. Mitaka T, Mikami M, Sattler GL, Pitot HC, Mochizuki Y. Small cell colonies appear in the primary culture of adult rat hepatocytes in the presence of nicotinamide and epidermal growth factor. Hepatology 1992; 16: 440-7.