Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1)

British Journal of Nutrition

Volumn 101, Issue 8, 2009, Pages 1150-1156

  Laftah, Abas H ^a   Latunde Dada, Gladys O ^a   Fakih, Sarah ^a   Hider, Robert C ^a   Simpson, Robert J ^a   McKie, Andrew T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Iron absorption; Iron deficiency; Metal nutrition; Proton coupled folate transporter haem carrier protein 1

Indexed keywords

FOLIC ACID; HEME; HEME CARRIER PROTEIN 1; IRON; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VITAMIN BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DUODENUM; FOLATE METABOLISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; IRON BINDING CAPACITY; MALE; MOUSE; NONHUMAN; PORPHYRIN METABOLISM; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSITIVITY AND SPECIFICITY; TRANSPORT KINETICS;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELLS, CULTURED; FOLIC ACID; HEME; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; JEJUNUM; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED STRAINS; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY;

MAMMALIA; MUS;

EID: 67649443910     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508066762     Document Type: Article

References (51)

1. Rong N, Selhub J, Goldin BR & Rosenberg IH (1991) Bacterially synthesized folate in rat large intestine is incorporated into host tissue folyl polyglutamates. J Nutr 121, 1955-1959.
2. Picciano MF (1999) Iron and folate supplementation: An effective intervention in adolescent females. Am J Clin Nutr 69, 1069-1070.
3. Selhub J, Jacques PF, Bostom AG, et al. (1996) Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Framingham Study population. J Nutr 126, Suppl. 4, 1258S-1265S.
4. Elsborg L & Larsen L (1979) Folate deficiency in chronic inflammatory bowel diseases. Scand J Gastroenterol 14, 1019-1024.
5. Alemdaroglu NC, Wolffram S, Boissel JP, Closs E, Spahn-Langguth H & Langguth P (2007) Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells. Planta Med 73, 27-32.
6. Hamid A, Wani NA, Rana S, Vaiphei K, Mahmood A & Kaur J (2007) Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. FEBS J 274, 6317-6328.
7. Geller J, Kronn D, Jayabose S & Sandoval C (2002) Hereditary folate malabsorption: Family report and review of the literature. Medicine (Baltimore) 81, 51-68.
8. Barber RC, Bennett GD, Greer KA & Finnell RH (1999) Expression patterns of folate binding proteins one and two in the developing mouse embryo. Mol Genet Metab 66, 31-39.
9. Finnell RH, Greer KA, Barber RC & Piedrahita JA (1998) Neural tube and craniofacial defects with special emphasis on folate pathway genes. Crit Rev Oral Biol Med 9, 38-53.
10. Halsted CH (1989) The intestinal absorption of dietary folates in health and disease. J Am Coll Nutr 8, 650-658.
11. Sirotnak FM & Tolner B (1999) Carrier-mediated membrane transport of folates in mammalian cells. Annu Rev Nutr 19, 91-122.
12. Antony AC (1996) Folate receptors. Annu Rev Nutr 16, 501-521.
13. Chiao JH, Roy K, Tolner B, Yang CH & Sirotnak FM (1997) RFC-1 gene expression regulates folate absorption in mouse small intestine. J Biol Chem 272, 11165-11170.
14. Kamen BA & Smith AK (2004) A review of folate receptor α cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro. Adv Drug Deliv Rev 56, 1085-1097.
15. Elwood PC (1989) Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. J Biol Chem 264, 14893-14901.
16. Lacey SW, Sanders JM, Rothberg KG, Anderson RG & Kamen BA (1989) Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosylphosphatidylinositol. J Clin Invest 84, 715-720.
17. Shen F, Ross JF, Wang X & Ratnam M (1994) Identification of a novel folate receptor, a truncated receptor, and receptor type β in hematopoietic cells: CDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry 33, 1209-1215.
18. Ratnam M, Marquardt H, Duhring JL & Freisheim JH (1989) Homologous membrane folate binding proteins in human placenta: Cloning and sequence of a cDNA. Biochemistry 28, 8249-8254.
19. Shen F, Wu M, Ross JF, Miller D & Ratnam M (1995) Folate receptor type γ is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: Protein characterization and cell type specificity. Biochemistry 34, 5660-5665.
20. Bracken CS, Baer MT, bdur-Rashid A, Helms W & Stojiljkovic I (1999) Use of heme-protein complexes by the Yersinia enterocolitica HemR receptor: Histidine residues are essential for receptor function. J Bacteriol 181, 6063-6072.
21. Wandersman C & Stojiljkovic I (2000) Bacterial heme sources: The role of heme, hemoprotein receptors and hemophores. Curr Opin Microbiol 3, 215-220.
22. Uzel C & Conrad ME (1998) Absorption of heme iron. Semin Hematol 35, 27-34.
23. Wyllie JC & Kaufman N (1982) An electron microscopic study of heme uptake by rat duodenum. Lab Invest 47, 471-476.
24. Raffin SB, Woo CH, Roost KT, Price DC & Schmid R (1974) Intestinal absorption of hemoglobin iron-heme cleavage by mucosal heme oxygenase. J Clin Invest 54, 1344-1352.
25. Tenhunen R, Grasbeck R, Kouvonen I & Lundberg M (1980) An intestinal receptor for heme: Its parital characterization. Int J Biochem 12, 713-716.
26. Grasbeck R, Kouvonen I, Lundberg M & Tenhunen R (1979) An intestinal receptor for heme. Scand J Haematol 23, 5-9.
27. Worthington MT, Cohn SM, Miller SK, Luo RQ & Berg CL (2001) Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. Am J Physiol Gastrointest Liver Physiol 280, G1172-G1177.
28. Galbraith RA (1990) Heme binding to Hep G2 human hepatoma cells. J Hepatol 10, 305-310.
29. Galbraith RA, Sassa S & Kappas A (1985) Heme binding to murine erythroleukemia cells. Evidence for a heme receptor. J Biol Chem 260, 12198-12202.
30. Shayeghi M, Latunde-Dada GO, Oakhill JS, et al. (2005) Identification of an intestinal heme transporter. Cell 122, 789-801.
31. Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH & Goldman ID (2006) Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127, 917-928.
32. Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH & Goldman ID (2007) Rodent intestinal folate transporters (SLC46A1): Secondary structure, functional properties, and response to dietary folate restriction. Am J Physiol Cell Physiol 293, C1669-C1678.
33. Inoue K, Nakai Y, Ueda S, Kamigaso S, Ohta KY, Hatakeyama M, Hayashi Y, Otagiri M & Yuasa H (2008) Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model. Am J Physiol Gastrointest Liver Physiol 294, G660-G668.
34. Follett JR, Suzuki YA & Lonnerdal B (2002) High specific activity heme-Fe and its application for studying heme-Fe metabolism in Caco-2 cell monolayers. Am J Physiol Gastrointest Liver Physiol 283 G1125-G1131.
35. Laftah AH, Raja KB, Latunde-Dada GO, Vergi T, McKie AT, Simpson RJ & Peters TJ (2005) Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice. Ann Hematol 84, 177-182.
36. Simpson RJ, Debnam ES, Laftah AH, Solanky N, Beaumont N, Bahram S, Schumann K & Srai SK (2003) Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out. Blood 101, 3316-3318.
37. 3+ uptake by mouse intestine. Cell Biochem Func 5, 69-76.
38. Takeuchi K, Bjarnason I, Laftah AH, Latunde-Dada GO, Simpson RJ & McKie AT (2005) Expression of iron absorption genes in mouse large intestine. Scand J Gastroenterol 40, 169-177.
39. Laftah AH, Ramesh B, Simpson RJ, Solanky N, Bahram S, Schumann K, Debnam ES & Srai SK (2004) Effect of hepcidin on intestinal iron absorption in mice. Blood 103, 3940-3944.
40. Balamurugan K & Said HM (2006) Role of reduced folate carrier in intestinal folate uptake. Am J Physiol Cell Physiol 291, C189-C193.
41. Chandler CJ, Wang TT & Halsted CH (1986) Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization. J Biol Chem 261, 928-933.
42. Wang TT, Chandler CJ & Halsted CH (1986) Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization. J Biol Chem 261, 13551-13555.
43. Kalpalathika M, Clark EM & Mahoney AW (1991) Heme iron content in selected ready-to-serve beef products. J Agric Food Chem 39, 1091-1093.
44. Subramanian VS, Chatterjee N & Said HM (2003) Folate uptake in the human intestine: Promoter activity and effect of folate deficiency. J Cell Physiol 196, 403-408.
45. Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y & Yuasa H (2007) Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther 322, 469-476.
46. Praetorius J, Andreasen D, Jensen BL, Ainsworth MA, Friis UG & Johansen T (2000) NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol 278, G197-G206.
47. Rothberg KG (1995) Caveolar targeting of glycosylphosphatidylinositol-anchored proteins. Methods Enzymol 250, 669-679.
48. Paulos CM, Reddy JA, Leamon CP, Turk MJ & Low PS (2004) Ligand binding and kinetics of folate receptor recycling in vivo: Impact on receptor-mediated drug delivery. Mol Pharmacol 66, 1406-1414.
49. Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP & Schuetz JD (2004) The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 279, 24218-24225.
50. Burckhardt G & Wolff NA (2000) Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 278, F853-F866.
51. Ruston D, Hoare J, Henderson L, Gregory J, Bates CJ, Prentice A, Birch M, Swan G & Farron M (2004) National Diet and Nutrition Survey, Adults aged 19-64 Years, vol. 4. London: The Stationery Office.