Ligand binding and kinetics of folate receptor recycling in vivo: Impact on receptor-mediated drug delivery

Molecular Pharmacology

Volumn 66, Issue 6, 2004, Pages 1406-1414

  Paulos, Chrystal M ^a   Reddy, Joseph A ^b   Leamon, Christopher P ^b   Turk, Mary Jo ^a   Low, Philip S ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b Endocyte Inc   (United States)

^c Department of Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG RECEPTOR; FLUORESCEIN ISOTHIOCYANATE; FOLATE RECEPTOR; FOLIC ACID; PENTETATE INDIUM IN 111; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG RELEASE; DRUG TARGETING; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG UPTAKE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNALIZATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RECYCLING;

ANIMALS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; ENDOCYTOSIS; FOLIC ACID; HELA CELLS; HUMANS; KB CELLS; LEUKEMIA L1210; LIGANDS; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; PENTETIC ACID; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 9444279605     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.003723     Document Type: Article

References (41)

1. Anderson RG, Kamen BA, Rothberg KG, and Lacey SW (1992) Potocytosis: sequestration and transport of small molecules by caveolae. Science (Wash DC) 255:410-411.
2. Birn H, Selhub J, and Christensen EI (1993) Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule. Am J Physiol 264:C302-C310.
3. Chang WJ, Rothberg KG, Kamen BA, and Anderson RG (1992) Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate. J Cell Biol 118:63-69.
4. Citro G, Szczylik C, Ginobbi P, Zupi G, and Calabretta B (1994) Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells. Br J Cancer 69:463-467.
5. Gabizon A, Horowitz AT, Goren D, Tzemach D, Mandelbaum-Shavit F, Qazen MM, and Zalipsky S (1999) Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: in vitro studies. Bioconjug Chem 10:289-298.
6. Kamen BA and Capdevila A (1986) Receptor-mediated folate accumulation is regulated by the cellular folate content. Proc Natl Acad Sci USA 83:5983-5987.
7. Kamen BA and Smith AK (2004) A review of folate receptor alpha cycling and 5 methyltetrahydrofolate accumulation with an emphasis on cell models in vitro. Adv Drug Deliv Rev 56:1085-1097.
8. Ladino CA, Chari RV, Bourret LA, Kedersha NL, and Goldmacher VS (1997) Folate-maytansinoids: target-selective drugs of low molecular weight. Int J Cancer 73:859-864.
9. Leamon CP and Low PS (1991) Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis. Proc Natl Acad Sci USA 88:5572-5576.
10. Leamon CP and Low PS (1992) Cytotoxicity of momordin-folate conjugates in cultured human cells. J Biol Chem 267:24966-24971.
11. Leamon CP and Low PS (1993) Membrane folate-binding proteins are responsible for folate-protein conjugate endocytosis into cultured cells. Biochem J 291:855-860.
12. Leamon CP and Low PS (2001) Folate-mediated targeting: from diagnostics to drug and gene delivery. Drug Discov Today 6:44-51.
13. 99mTc-based radiopharmaceutical. Bioconjug Chem 13:1200-1210.
14. Leamon CP, Pastan I, and Low PS (1993) Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain. J Biol Chem 268:24847-24854.
15. Lee RJ and Huang L (1996) Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J Biol Chem 271:8481-8487.
16. Lee RJ and Low PS (1994) Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J Biol Chem 269:3198-3204.
17. Lee RJ and Low PS (1995) Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim Biophys Acta 1233:134-144.
18. Lu Y and Low PS (2002a) Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 54:675-693.
19. Lu Y and Low PS (2002b) Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors. Cancer Immunol Immunother 51:153-162.
20. Lu Y, Lowe DA, Kennedy MD, and Low PS (1999) Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug. J Drug Target 7:43-53.
21. Paulos CM, Turk MJ, Breur GJ, and Low PS (2004) Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Acta Drug Delivery Rev 56:1205-1217.
22. 111In]In-DTPA-folate, a folate-receptor-targeted radiopharmaceutical. Nucl Med Biol 25:585-587.
23. Mathias CJ, Wang S, Lee RJ, Waters DJ, Low PS, and Green MA (1996) Tumor-selective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67-deferoxamine-folate. J Nucl Med 37:1003-1008.
24. Mathias CJ, Wang S, Waters DJ, Turek JJ, Low PS, and Green MA (1998) Indium-111-DTPA-folate as a potential folate-receptor-targeted radiopharmaceutical. J Nucl Med 39:1579-1585.
25. Maxfield FR and McGraw TE (2004) Endocytic Recycling. Nature Rev Mol Cell Biology 5:121-132.
26. Oyewumi MO and Mumper RJ (2003) Influence of formulation parameters on gadolinium entrapment and tumor cell uptake using folate-coated nanoparticles. Int J Pharm 251:85-97.
27. Reddy JA and Low PS (1998) Folate-mediated targeting of therapeutic and imaging agents to cancers. Crit Rev Ther Drug Carrier Syst 15:587-627.
28. Reddy JA, Dean D, Kennedy MD, and Low PS (1999) Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy. J Pharm Sci 88:1112-1118.
29. Reddy JA, Abburi C, Hofland H, Howard SJ, Vlahov I, Wils P, and Leamon CP (2002) Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors. Gene Ther 9:1542-1550.
30. Reddy JA and Low PS (2000) Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation. J Control Release 64:27-37.
31. Rijnboutt S, Jansen G, Posthuma G, Hynes JB, Schornagel JH, and Strous GJ (1996) Endocytosis of GPI-linked membrane folate receptor-alpha. J Cell Biol 132:35-47.
32. Ritter TE, Fajardo O, Matsue H, Anderson RG, and Lacey SW (1995) Folate receptors targeted to clathrin-coated pits cannot regulate vitamin uptake. Proc Natl Acad Sci USA 92:3824-3828.
33. Rodman JS, Seidman L, and Farquhar MG (1986) The membrane composition of coated pits, microvilli, endosomes and lysosomes is distinctive in the rat kidney proximal tubule cell. J Cell Biol 102:77-87.
34. Rothberg KG, Ying YS, Kolhouse JF, Kamen BA, and Anderson RG (1990) The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway. J Cell Biol 110:637-649.
35. Smart EJ, Foster DC, Ying YS, Kamen BA, and Anderson RG (1994) Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae. J Cell Biol 124:307-313.
36. Turek JJ, Leamon CP, and Low PS (1993) Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells. J Cell Sci 106:423-430.
37. Turk MJ, Breur GJ, Widmer WR, Paulos CM, Xu LC, Grote LA, and Low PS (2002) Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum 46:1947-1955.
38. Wang S, Lee RJ, Cauchon G, Gorenstein DG, and Low PS (1995) Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc Natl Acad Sci USA 92:3318-3322.
39. Wang S, Lee RJ, Mathias CJ, Green MA, and Low PS (1996) Synthesis, purification and tumor cell uptake of 67Ga-deferoxamine-folate, a potential radiopharmaceutical for tumor imaging. Bioconjug Chem 7:56-62.
40. 111In]DTPA-folate for use as a tumor-targeted radiopharmaceutical. Bioconjug Chem 8:673-679.
41. Wang S and Low PS (1998) Folate-mediated targeting of antineoplastic drugs, imaging agents and nucleic acids to cancer cells. J Control Release 53:39-48.