Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Framingham Study Population

Journal of Nutrition

Volumn 126, Issue 4 SUPPL., 1996, Pages

  Selhub, Jacob ^a   Jacques, Paul F ^a   Bostom, Andrew G ^b   D'Agostino, Ralph B ^c   Wilson, Peter W F ^b   Belanger, Albert J ^c   O'Leary, Daniel H ^d   Wolf, Philip A ^e,f   Rush, David ^a   Schaefer, Ernst J ^a   Rosenberg, Irwin H ^a  

^a TUFTS UNIVERSITY   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

^c Boston University   (United States)

^d GEISINGER MEDICAL CENTER   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BOSTON MEDICAL CENTER   (United States)

Author keywords

arteriosclerosis; folic acid; homocysteine; pyridoxal phosphate; vitamin B 12; vitamin B 6

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE;

ADULT; AGED; AMINO ACID METABOLISM; ARTERIOSCLEROSIS; CAROTID ARTERY OBSTRUCTION; CIGARETTE SMOKING; CONFERENCE PAPER; DRUG BLOOD LEVEL; ENZYME DEFICIENCY; FEMALE; HOMOCYSTINURIA; HUMAN; MAJOR CLINICAL STUDY; MALE; SYSTOLIC BLOOD PRESSURE; TISSUE DISTRIBUTION; VITAMIN INTAKE;

EID: 9244221085     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.suppl_4.1258s     Document Type: Conference Paper

References (32)

1. Araki, A. & Sako, Y. (1987) Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr. 422: 43-52.
2. Brattstrom, L. E., Israelsson, B., Jeppsson, J.-O. & Hultberg, B. L. (1988) Folic acid-an innocuous means to reduce plasma homocysteine. Scand J. Clin. Lab. Invest. 48: 215-221.
3. Brattstrom, L., Israelsson, B., Norrving, E., et al. (1990) Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis 81: 51-60.
4. Clarke, R., Daly, L., Robinson, K., et al. (1991) Hyperhomocysteinemia: an independent risk factor for vascular disease. N. Engl. J. Med. 324: 1149-1155.
5. Clarke, R., Fitzgerald, D., O'Brien, C., et al. (1992) Hyperhomocysteinaemia: a risk factor for extracranial carotid artery atherosclerosis. Ir. J. Med. Sci. 161: 61-65.
6. Camp, V. M., Chipponi, J. & Faraj, B. A. (1983) Radioenzymatic assay for direct measurement of pyridoxal 5′-phosphate. Clin. Chem 29: 642-644.
7. Dawber, T. R., Moore, F. E. & Mann, G. V. (1957) Coronary heart disease in the Framingham study. Am. J. Public Health 47 (suppl): 4-24.
8. Dudman, N. P. B., Wilcken, D. E. L., Wang, J., Lynch, J. F., Macey, D. & Lundberg, P. (1993) Disordered methionine/homocysteine metabolism in premature vascular disease: its occurrence, cofactor therapy, and enzymology. Arterioscler. Thromb. 13: 1253-1260.
9. Franken, D. G., Boers, G. H. J., Blom, H. J. & Trijbels, J. M. F. (1994) Effect of various regimens of vitamin B-6 and folic acid on mild hyperhomocysteinemia in vascular patients. J. Inher. Metab. Dis. 17: 159-162.
10. Genest, J. J., McNamara, J. R., Salem, D. N., Wilson, P. W. F., Schaefer, E. J. & Malinow, M. R. (1990) Plasma homocyst(e)ine levels in men with premature coronary artery disease. J. Am. Coll. Cardiol. 16: 1114-1119.
11. Glueck, C. J., Shaw, P., Lang, J. E., Tracy, T., Sieve-Smith, L. & Wang, Y. (1995) Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am. J. Cardiol. 132-136.
12. Jacques, P. F., Sulsky, S. I., Sadowski, J. A., Phillips, J. C. C., Rush, D. & Willett, W. C. (1993) Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient status. Am. J. Clin. Nutr. 57: 182-189.
13. Joosten, E., van den Berg, A., Riezler, R., et al. (1993) Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am. J. Clin. Nutr. 58: 468-76.
14. Kleinbaum, D. G., Kupper, L. L. & Muller, K. E. (1988) Applied regression analysis and other multivariate methods, 2nd ed. PWS-Kent Publishing, Boston, MA.
15. Lindgren, F., Israelsson, B., Lindgren, A., Hultberg, B., Andersson, A. & Brattstrom, L. (1995) Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. J. Intern. Med. 237: 381-388.
16. Malinow, M. R., Nieto, F. J., Szklo, M., Chambless, L. E. & Bond, M. G. (1993) Carotid artery intimal-medial thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation 87: 1107-1113.
17. McCully, K. S. (1969) Vascular pathology of homocysteinemia: implications for pathogenesis of arteriosclerosis. Am. J. Pathol. 56: 111-128.
18. McNamara, J. R. & Schaefer, E. J. (1987) Automated enzymatic standard lipid analyses for plasma and lipoprotein fractions. Clin. Chim. Acta 166: 1-8.
19. Mudd, S. H., Levy, H. L., Skovby, F. (1989) Disorders of transsulfuration. In: Metabolic Basis of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D., eds.) 6th ed. pp. 693-734. McGraw Hill, New York, NY.
20. Rothman, K. J. (1986) Modem Epidemiology. Little, Brown, Boston, MA.
21. Rubba, P., Faccenda, F., Pauciullo, P., et al. (1990) Early signs of vascular disease in homocystinuria: a noninvasive study by ultrasound methods in eight families with cystathionine beta synthase deficiency. Metabolism 39: 1191-1195.
22. Selhub, J., Jacques, P. F., Bostom, A. G., D'Agostino, R. B., Wilson, P. W. F., Belanger, A. J., O'Leary, D. H., Wolf, P. A., Schaefer, E. J. & Rosenberg, I. H. (1995) Plasma homocysteine and extracranial carotid stenosis in the framingham heart study. N. Engl. J. Med. 332: 286-291.
23. Selhub, J., Jacques, P. F., Wilson, P. W. F., Rush, D. & Rosenberg, I. H. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J. Am. Med. Assoc. 270: 2693-2698.
24. Stampfer, M. J., Malinow, M. R., Willett, W. C., et al. (1992) A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in U.S. physicians. J. Am. Med. Assoc. 268: 877-881.
25. Tamura, T., Freeberg, L. E. & Cornwell, P. E. (1990) Inhibition by EDTA of growth of lactobacillus casei in the folate microbiological assay and its reversal by added manganese or iron. Clin. Chem. 36: 1993.
26. Ubbink, J. B., Vermaak, W. J., van der Merwe, A., Becker, P. J. (1993) Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am. J. Clin. Nutr. 57: 47-53.
27. Ubbink, J. B., Vermaak, W. J. H., van der Merwe, A., Becker, P. J., et al. (1994) Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J. Nutr. 124: 1927-1933.
28. Ueland, P. M. & Refsum, H. (1989) Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy. J. Lab. Clin. Med. 114: 473-501.
29. Ueland, P. M., Refsum, H. & Brattstrom, L. (1992) Plasma homocysteine and cardiovascular disease. In: Atherosclerotic Cardiovascular Disease Hemostasis, and Endothelial Function (Francis, R. B. J., ed.), pp. 183-236. Marcel Dekker, New York, NY.
30. Warnick, G. R., Benderson, J. & Albers, J. J. (1982) Dextran sulfate-magnesium precipitation procedure for quantitation of high-density lipoprotein cholesterol. Clin. Chem. 28: 1379-1382.
31. Willett, W. (1990) Nutritional Epidemiology, pp. 92-126. Oxford University Press, New York, NY.
32. Willett, W. C., Sampson, L. S., Stampfer, M. J., et al. (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am. J. Epidemiol. 122: 51-65.