-
1
-
-
0028349735
-
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong Z., Wen Z., and Darnell Jr. J.E. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264 (1994) 95-98
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell Jr., J.E.3
-
2
-
-
0030840464
-
STATs and gene regulation
-
Darnell Jr. J.E. STATs and gene regulation. Science 277 (1997) 1630-1635
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Darnell Jr., J.E.1
-
3
-
-
0036731485
-
Stats: transcriptional control and biological impact
-
Levy D.E., and Darnell Jr. J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell. Biol. 3 (2002) 651-662
-
(2002)
Nat. Rev. Mol. Cell. Biol.
, vol.3
, pp. 651-662
-
-
Levy, D.E.1
Darnell Jr., J.E.2
-
4
-
-
0034657447
-
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled
-
Reddy E.P., Korapati A., Chaturvedi P., and Rane S. IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled. Oncogene 19 (2000) 2532-2547
-
(2000)
Oncogene
, vol.19
, pp. 2532-2547
-
-
Reddy, E.P.1
Korapati, A.2
Chaturvedi, P.3
Rane, S.4
-
5
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
Darnell Jr. J.E., Kerr I.M., and Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994) 1415-1421
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell Jr., J.E.1
Kerr, I.M.2
Stark, G.R.3
-
6
-
-
0035651001
-
EGFR dependent expression of STAT3 (but not STAT1) in breast cancer
-
Berclaz G., Altermatt H.J., Rohrbach V., Siragusa A., Dreher E., and Smith P.D. EGFR dependent expression of STAT3 (but not STAT1) in breast cancer. Int. J. Oncol. 19 (2001) 1155-1160
-
(2001)
Int. J. Oncol.
, vol.19
, pp. 1155-1160
-
-
Berclaz, G.1
Altermatt, H.J.2
Rohrbach, V.3
Siragusa, A.4
Dreher, E.5
Smith, P.D.6
-
7
-
-
0037386568
-
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
-
Leong P.L., Andrews G.A., Johnson D.E., et al. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 4138-4143
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 4138-4143
-
-
Leong, P.L.1
Andrews, G.A.2
Johnson, D.E.3
-
8
-
-
0036604124
-
Stat3 activation in prostatic carcinomas
-
Dhir R., Ni Z., Lou W., DeMiguel F., Grandis J.R., and Gao A.C. Stat3 activation in prostatic carcinomas. Prostate 51 (2002) 241-246
-
(2002)
Prostate
, vol.51
, pp. 241-246
-
-
Dhir, R.1
Ni, Z.2
Lou, W.3
DeMiguel, F.4
Grandis, J.R.5
Gao, A.C.6
-
9
-
-
0032984589
-
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
Catlett-Falcone R., Landowski T.H., Oshiro M.M., et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10 (1999) 105-115
-
(1999)
Immunity
, vol.10
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
-
10
-
-
18644380911
-
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
-
Niu G., Bowman T., Huang M., et al. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene 21 (2002) 7001-7010
-
(2002)
Oncogene
, vol.21
, pp. 7001-7010
-
-
Niu, G.1
Bowman, T.2
Huang, M.3
-
12
-
-
33645067376
-
Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3
-
Leslie K., Lang C., Devgan G., et al. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 66 (2006) 2544-2552
-
(2006)
Cancer Res.
, vol.66
, pp. 2544-2552
-
-
Leslie, K.1
Lang, C.2
Devgan, G.3
-
13
-
-
0035912763
-
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
-
Bowman T., Broome M.A., Sinibaldi D., et al. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 7319-7324
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 7319-7324
-
-
Bowman, T.1
Broome, M.A.2
Sinibaldi, D.3
-
14
-
-
85047699293
-
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
-
Zamo A., Chiarle R., Piva R., et al. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 21 (2002) 1038-1047
-
(2002)
Oncogene
, vol.21
, pp. 1038-1047
-
-
Zamo, A.1
Chiarle, R.2
Piva, R.3
-
15
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
Niu G., Wright K.L., Huang M., et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21 (2002) 2000-2008
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
-
16
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell Jr. J.E. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2 (2002) 740-749
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 740-749
-
-
Darnell Jr., J.E.1
-
17
-
-
20844444135
-
Targeting Stat3 in cancer therapy
-
Jing N., and Tweardy D.J. Targeting Stat3 in cancer therapy. Anticancer Drugs 16 (2005) 601-607
-
(2005)
Anticancer Drugs
, vol.16
, pp. 601-607
-
-
Jing, N.1
Tweardy, D.J.2
-
18
-
-
1042302005
-
The STATs of cancer - new molecular targets come of age
-
Yu H., and Jove R. The STATs of cancer - new molecular targets come of age. Nat. Rev. Cancer 4 (2004) 97-105
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
19
-
-
33947574564
-
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution
-
Aggarwal B.B., Sethi G., Ahn K.S., et al. Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Ann. N. Y. Acad. Sci. 1091 (2006) 151-169
-
(2006)
Ann. N. Y. Acad. Sci.
, vol.1091
, pp. 151-169
-
-
Aggarwal, B.B.1
Sethi, G.2
Ahn, K.S.3
-
20
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich M.A., Sun J., Cantor A., Turkson J., Jove R., and Sebti S.M. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63 (2003) 1270-1279
-
(2003)
Cancer Res.
, vol.63
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
21
-
-
34247154498
-
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
-
Iwamaru A., Szymanski S., Iwado E., et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 26 (2007) 2435-2444
-
(2007)
Oncogene
, vol.26
, pp. 2435-2444
-
-
Iwamaru, A.1
Szymanski, S.2
Iwado, E.3
-
22
-
-
0035977055
-
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
-
Turkson J., Ryan D., Kim J.S., et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem. 276 (2001) 45443-45455
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45443-45455
-
-
Turkson, J.1
Ryan, D.2
Kim, J.S.3
-
24
-
-
38649086742
-
Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target
-
Timofeeva O.A., Gaponenko V., Lockett S.J., et al. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS Chem. Biol. 2 (2007) 799-809
-
(2007)
ACS Chem. Biol.
, vol.2
, pp. 799-809
-
-
Timofeeva, O.A.1
Gaponenko, V.2
Lockett, S.J.3
-
25
-
-
25444513779
-
A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
-
Turkson J., Zhang S., Mora L.B., Burns A., Sebti S., and Jove R. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J. Biol. Chem. 280 (2005) 32979-32988
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 32979-32988
-
-
Turkson, J.1
Zhang, S.2
Mora, L.B.3
Burns, A.4
Sebti, S.5
Jove, R.6
-
26
-
-
50949096570
-
T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling
-
Weerasinghe P., Li Y., Guan Y., Zhang R., Tweardy D.J., and Jing N. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate 68 (2008) 1430-1442
-
(2008)
Prostate
, vol.68
, pp. 1430-1442
-
-
Weerasinghe, P.1
Li, Y.2
Guan, Y.3
Zhang, R.4
Tweardy, D.J.5
Jing, N.6
-
28
-
-
54349127051
-
Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein
-
Fletcher S., Turkson J., and Gunning P.T. Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein. ChemMedChem 3 (2008) 1159-1168
-
(2008)
ChemMedChem
, vol.3
, pp. 1159-1168
-
-
Fletcher, S.1
Turkson, J.2
Gunning, P.T.3
-
29
-
-
34250367390
-
New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors
-
Dourlat J., Valentin B., Liu W.Q., and Garbay C. New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors. Bioorg. Med. Chem. Lett. 17 (2007) 3943-3946
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 3943-3946
-
-
Dourlat, J.1
Valentin, B.2
Liu, W.Q.3
Garbay, C.4
-
30
-
-
16344380754
-
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
-
Song H., Wang R., Wang S., and Lin J. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 4700-4705
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 4700-4705
-
-
Song, H.1
Wang, R.2
Wang, S.3
Lin, J.4
-
31
-
-
33750982120
-
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
-
Schust J., Sperl B., Hollis A., Mayer T.U., and Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 13 (2006) 1235-1242
-
(2006)
Chem. Biol.
, vol.13
, pp. 1235-1242
-
-
Schust, J.1
Sperl, B.2
Hollis, A.3
Mayer, T.U.4
Berg, T.5
-
32
-
-
34250658084
-
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
-
Siddiquee K., Zhang S., and Guida W.C. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 7391-7396
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 7391-7396
-
-
Siddiquee, K.1
Zhang, S.2
Guida, W.C.3
-
33
-
-
38649129118
-
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects
-
Siddiquee K.A., Gunning P.T., and Glenn M. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS Chem. Biol. 2 (2007) 787-798
-
(2007)
ACS Chem. Biol.
, vol.2
, pp. 787-798
-
-
Siddiquee, K.A.1
Gunning, P.T.2
Glenn, M.3
-
34
-
-
58149392583
-
Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders
-
Gunning P.T., Glenn M.P., Siddiquee K.A., et al. Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders. ChemBioChem 9 (2008) 2800-2803
-
(2008)
ChemBioChem
, vol.9
, pp. 2800-2803
-
-
Gunning, P.T.1
Glenn, M.P.2
Siddiquee, K.A.3
-
35
-
-
0037507282
-
Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3
-
Wiederkehr-Adam M., Ernst P., Muller K., et al. Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3. J. Biol. Chem. 278 (2003) 16117-16128
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16117-16128
-
-
Wiederkehr-Adam, M.1
Ernst, P.2
Muller, K.3
-
36
-
-
0001141466
-
Synthesis and application of bis-silylethyl-derived phosphate-protected Fmoc-phosphotyrosine derivatives for peptide synthesis
-
Chao H.G., Bernatowicz M.S., Reiss P.D., and Matsueda G.R. Synthesis and application of bis-silylethyl-derived phosphate-protected Fmoc-phosphotyrosine derivatives for peptide synthesis. J. Org. Chem. 59 (1994) 6687-6691
-
(1994)
J. Org. Chem.
, vol.59
, pp. 6687-6691
-
-
Chao, H.G.1
Bernatowicz, M.S.2
Reiss, P.D.3
Matsueda, G.R.4
-
37
-
-
0031193332
-
Fluorescein-conjugated lysine monomers for solid phase synthesis of fluorescent peptides and PNA oligomers
-
Lohse J., Nielsen P.E., Harrit N., and Dahl O. Fluorescein-conjugated lysine monomers for solid phase synthesis of fluorescent peptides and PNA oligomers. Bioconjug. Chem. 8 (1997) 503-509
-
(1997)
Bioconjug. Chem.
, vol.8
, pp. 503-509
-
-
Lohse, J.1
Nielsen, P.E.2
Harrit, N.3
Dahl, O.4
-
38
-
-
2442618276
-
Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif
-
Shao H., Xu X., and Mastrangelo M.A. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J. Biol. Chem. 279 (2004) 18967-18973
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18967-18973
-
-
Shao, H.1
Xu, X.2
Mastrangelo, M.A.3
-
39
-
-
0028239908
-
The third helix of the Antennapedia homeodomain translocates through biological membranes
-
Derossi D., Joliot A.H., Chassaing G., and Prochiantz A. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem. 269 (1994) 10444-10450
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 10444-10450
-
-
Derossi, D.1
Joliot, A.H.2
Chassaing, G.3
Prochiantz, A.4
-
40
-
-
0029916933
-
Activation and association of Stat3 with Src in v-Src-transformed cell lines
-
Cao X., Tay A., Guy G.R., and Tan Y.H. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 16 (1996) 1595-1603
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1595-1603
-
-
Cao, X.1
Tay, A.2
Guy, G.R.3
Tan, Y.H.4
-
41
-
-
0031893214
-
Stat3 activation is required for cellular transformation by v-src
-
Bromberg J.F., Horvath C.M., Besser D., Lathem W.W., and Darnell Jr. J.E. Stat3 activation is required for cellular transformation by v-src. Mol. Cell. Biol. 18 (1998) 2553-2558
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2553-2558
-
-
Bromberg, J.F.1
Horvath, C.M.2
Besser, D.3
Lathem, W.W.4
Darnell Jr., J.E.5
-
42
-
-
26844543749
-
Medium-sized peptides as built in carriers for biologically active compounds
-
Hudecz F., Banoczi Z., and Csik G. Medium-sized peptides as built in carriers for biologically active compounds. Med. Res. Rev. 25 (2005) 679-736
-
(2005)
Med. Res. Rev.
, vol.25
, pp. 679-736
-
-
Hudecz, F.1
Banoczi, Z.2
Csik, G.3
-
43
-
-
0028349904
-
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
-
Shuai K., Horvath C.M., Huang L.H., Qureshi S.A., Cowburn D., Darnell Jr. J.E., et al. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76 (1994) 821-828
-
(1994)
Cell
, vol.76
, pp. 821-828
-
-
Shuai, K.1
Horvath, C.M.2
Huang, L.H.3
Qureshi, S.A.4
Cowburn, D.5
Darnell Jr., J.E.6
-
44
-
-
0034687854
-
Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation
-
Dostmann W.R., Taylor M.S., Nickl C.K., Brayden J.E., Frank R., and Tegge W.J. Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 14772-14777
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 14772-14777
-
-
Dostmann, W.R.1
Taylor, M.S.2
Nickl, C.K.3
Brayden, J.E.4
Frank, R.5
Tegge, W.J.6
-
45
-
-
67649455001
-
Peptidomimetic inhibitors of Stat3: Structure-activity relationships and cellular activity
-
Z. Ren, D.R. Coleman, P.K. Mandal, et al, Peptidomimetic inhibitors of Stat3: structure-activity relationships and cellular activity, in: 16th EORTC-NCI-AACR, Symposium on Molecular Targets and Cancer Therapeutics, 2004.
-
(2004)
16th EORTC-NCI-AACR, Symposium on Molecular Targets and Cancer Therapeutics
-
-
Ren, Z.1
Coleman, D.R.2
Mandal, P.K.3
|