The role of γ-hydroxybutyric acid in the treatment of alcoholism from animal to clinical studies

Alcohol and Alcoholism

Volumn 34, Issue 1, 1999, Pages 15-24

  Poldrugo, Flavio ^a   Addolorato, Giovanni ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; GAMMA BUTYROLACTONE;

4 AMINOBUTYRIC ACID METABOLISM; ALCOHOL METABOLISM; ALCOHOLISM; ANXIETY NEUROSIS; CLINICAL PRACTICE; DEPRESSION; DOSE RESPONSE; DRUG ABUSE; DRUG DEPENDENCE; DRUG ELIMINATION; DRUG MECHANISM; DRUG RESEARCH; ELECTROENCEPHALOGRAM; HUMAN; MENTAL DISEASE; NARCOLEPSY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; SEDATION; SIDE EFFECT; WITHDRAWAL SYNDROME;

ALCOHOLISM; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; ETHANOL; GABA AGONISTS; HYDROXYBUTYRATES; MICE; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0032950610     PISSN: 07350414     EISSN: None     Source Type: Journal    
DOI: 10.1093/alcalc/34.1.15     Document Type: Review

References (109)

1. Addolorato, G., Stefanini, G. F., Casella, G., Marsigli, L., Caputo, F. and Gasbarrini, G. (1995) Evaluation of the therapeutic efficacy of gamma-hydroxybutyric acid in the medium-term treatment of alcoholic outpatients. Preliminary data from an open multicentric study. Alcologia: European Journal of Alcohol Studies 1, 233-236.
2. Addolorato, G., Castelli, E., Stefanini, G. F., Casella, G., Caputo, F., Marsigli, L., Bernardi, M. and Gasbarrini, G. (1996) An open multicentric study evaluating 4-hydroxybutyric acid sodium salt in the medium-term treatment of 179 alcohol dependent subjects. Alcohol and Alcoholism 31, 341-345.
3. Addolorato, G., Stefanini, G. F. and Gasbarrini, G. (1997a) Manageability and tolerability of gamma-hydroxybutyric acid in the medium-term outpatient treatment of alcoholism. Alcoholism: Clinical and Experimental Research 21, 380.
4. Addolorato, G., Caputo, F., Stefanini, G. F. and Gasbarrini, G. (1997b) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: possible craving development for the drug. Addiction 92, 1041-1042.
5. Addolorato, G., Cibin, M., Capristo, E., Beghe', F., Gessa, G. L., Stefanini, G. F. and Gasbarrini, G. (1998a) Maintaining abstinence from alcohol by gamma-hydroxybutyric acid. Lancet 351, 38.
6. Addolorato, G., Cibin, M., Caputo, F., Capristo, E., Gessa, G. L., Stefanini, G. F. and Gasbarrini, G. (1998b) Gamma-hydroxybutyric acid in the treatment of alcoholism: dosage fractioning utility in non-responder alcoholic patients. Drug and Alcohol Dependence, in press.
7. Anderson, R. A., Ritzmann, R. F. and Tabakoff, B. (1977) Formation of gamma-hydroxybutyrate in brain. Journal of Neurochemistry 28, 633-639.
8. Andronova, L. M. and Barkov, N. K. (1981) The effects of neuroleptics, tranquillizers, narcotics, antidepressant and anticonvulsive drugs on the alterations of mouse behaviour caused by acetaldehyde. Drug and Alcohol Dependence 8, 85-92.
9. Arena, C. and Fung, H. L. (1980) Absorption of sodium gamma-hydroxybutyrate and its prodrug gamma-butyrolactone: relationship between in vitro transport and in vivo absorption. Journal of Pharmaceutical Sciences 69, 356-358.
10. Ban, T., Takaori, S., Sasa, M. and Shimamoto, K. (1967) The central action of gamma-butyrolactone and gamma-hydroxybutyrate. Japanese Journal of Pharmacology 17, 30-45.
11. Barker, S. A., Snead, O. C., Poldrugo, F., Liu, C. C. F. P. and Settine, R. L. (1985) The identification and quantitation of 1,4 butanediol in mammalian tissues: an alternative biosynthetic pathway for gamma-hydroxybutyric acid. Biochemical Pharmacology 34, 1849-1852.
12. Benavides, J., Rumigny, J. F., Bourguignon, J. J., Cash, C., Wermuth, C. G., Mandel, P., Vincendon, G. and Maitre, M. (1982) High affinity binding site for gamma-hydroxybutyric acid in rat brain. Life Sciences 30, 953-961.
13. Benton, D., Kyriacou, C. P., Rick, J. T. and Taberner, P. V. (1974) Behavioural interactions between imidazol acetic and gamma-hydroxybutyric acids in rats and mice. European Journal of Pharmacology 27, 288-293.
14. Bergelson, L. D., Vaver, V. A., Prokazova, N. V., Ushakov, A. N. and Popkova, G. A. (1966) Diol lipids. Biochimica et Biophysica Acta 116, 511-520.
15. Bessman, S. P. and McCabe, E. R. B. (1972) 1,4 Butanediol - a substrate for rat liver and horse liver alcohol dehydrogenase. Biochemical Pharmacology 21, 1135-1142.
16. Burov, Y. N., Treskov, V. G., Drozdov, E. S. and Kovalenko, A. E. (1983) Effect of tranquillizers on blood endogenous ethanol level in alcoholics. Biulletin Experimentalnoi Biologii i Meditsiny 95, 60-62.
17. Cash, C., Ciesielski, L., Maitre, M. and Mandel, P. (1977) Purification and properties of rat brain succinic semialdehyde dehydrogenase. Biochimie 59, 257-268.
18. Colombo, G., Agabio, R., Lobina, C., Reali, R., Fadda, F. and Gessa, G. L. (1995) Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: occurrence within narrow dose ranges. Physiology and Behavior 57, 105-111.
19. Colombo, G., Agabio, R., Lobina, C., Loche, A., Reali, R. and Gessa, G. L. (1998) High sensitivity to y-hydroxybutyric acid in ethanol-preferring sP rats. Alcohol and Alcoholism 33, 121-125.
20. Cott, J., Carlsson, A., Engel, J. and Lindqvist, M. (1976) Suppression of ethanol-induced locomotor stimulation by GABA-like drugs. Naunyn-Schmiedeberg's Archives of Pharmacology 295, 203-209.
21. Danon-Boileau, H., Lavitry, S., Lab, P., Levy, E., Ruffiot, S. and Laborit, H. (1962) Utilisation en psychiatrie du gamma-OH. La Presse Medicale 70, 2205-2207.
22. Divry, P., Baltassat, P., Rolland, M. O., Cotte, J., Hermier, M., Duran, M. and Wadman, S. K. (1983) A new patient with 4-hydroxybutyric aciduria, a possible defect of 4-aminobutyrate metabolism. Clinica Chimica Acta 12, 303-309.
23. 14C]-hydroxybutyric acid in rat brain after intraventricular injection. Biochemical Pharmacology 24, 469-474.
24. Doherty, J. D., Hattox, S. E., Snead, O. C. and Roth, R. H. (1978) Identification of endogenous gamma-hydroxybutyrate in human and bovine brain and its regional distribution in human, guinea-pig, and rhesus monkey brain. Journal of Pharmacology and Experimental Therapeutics 207, 130-139.
25. du Couedic, H., du Couedic, A. and Voisse, M. (1964) Contribution a l'étude du 4-hydroxybutyrate de Na (4OH) dans le traitment des états anxieux aigus. Agressologie 5, 73-83.
26. Dudek, B. C. and Fanelli, R. J. (1980) Effects of gamma-butyrolactone, amphetamine, and haloperidol in mice differing in sensitivity to alcohol. Psychopharmacology 15, 711-721.
27. Einspruch, B. C. and Clark, S. M. (1992) Near fatality results from health food store sleeping potion. Texas Medicine 88, 10.
28. Fadda, F., Argiolas, A., Melis, M. R., De Montis, G. and Gessa, G. L. (1983) Suppression of voluntary ethanol consumption in rats by gamma-butyrolactone. Life Sciences 32, 1471-1477.
29. Fadda, F., Mosca, E., Colombo, G. and Gessa, G. L. (1989) Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats. Alcohol and Alcoholism 24, 447-451.
30. Ferrara, S. D., Zotti, S., Tedeschi, L., Frison, G., Castagna, F., Gallimberti, L., Gessa, G. L. and Palatini, P. (1992) Pharmacokinetics of gamma-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses. British Journal of Clinical Pharmacology 34, 231-235.
31. Food and Drug Administration Agency (1991a) Multistate outbreak of poisonings associated with illicit use of gamma hydroxybutyrate. Journal of the American Medical Association 265, 447-448.
32. Food and Drug Administration Agency (1991e) Warning about GHB. Journal of the American Medical Association 265, 1802.
33. Frau, M., Colombo, G., Marchese, G., Stefanini, E. and Gessa, G. L. (1995) Different affinity of cortical GHB binding sites in Sardinian alcohol-preferring (sP) and non-preferring (sNP) rats. Alcohol and Alcoholism 30, 133-137.
34. Gallimberti, L., Canton, G., Gentile, N., Cibin, M., Ferri, M., Ferrara, S. D., Fadda, F. and Gessa, G. L. (1989) Gamma-hydroxybutyric acid for the treatment of alcohol withdrawal syndrome. Lancet ii, 787-789.
35. Gallimberti, L., Ferri, M., Ferrara, S. D., Fadda, F. and Gessa, G. L. (1992) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: a double blind study. Alcoholism: Clinical and Experimental Research 16, 673-676.
36. Galloway, G. P., Frederick, S. L., Staggers, F. E., Gonzales, M., Stalcup, S. A. and Smith, D. E. (1997) Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence. Addiction 92, 89-96.
37. Gessa, G. L., Vargiu, L., Crabai, F., Boero, G. C., Caboni, F. and Camba, R. (1966) Selective increase of brain dopamine induced by gamma-hydroxybutyrate. Life Sciences 5, 1921-1930.
38. Gessa, G. L., Crabai, F., Vargiu, L. and Spano, P. F. (1968) Selective increase of brain dopamine induced by gamma-hydroxybutyrate: study of the mechanism of action. Journal of Neurochemistry 15, 377-381.
39. Gessner, P. K., Parke, D. V. and Williams, R. T. (1960) Studies in detoxication. 80. The metabolism of glycols. Biochemical Journal 74, 1-5.
40. Giarman, N. J. and Roth, R. H. (1964) Differential estimation of gamma-butyrolactone and gamma-hydroxybutyric acid in rat blood and brain. Science 145, 583-584.
41. 3(H)aminobutyric acid to gamma-(H)hydroxybutyric acid by rat brain. Journal of Neurochemistry 28, 1069-1073.
42. Helrich, M. D., McAsian, T. C., Skolnik, S. and Bessman, S. P. (1964) Correlation of blood levels of 4-hydroxybulyrate with state of consciousness. Anesthesiology 23, 771-775.
43. Hinrichs, A., Kopf, R. and Loeser, A. (1948) Zur Toxicologie des 1,4-Butanediol. Pharmazia 3, 110-116.
44. Hoes, M. J., Vree, T. B. and Guelen, P. J. (1978) Enhanced plasma concentrations of gamma-hydroxybutyric acid in alcoholics. British Journal of Addiction 73, 423-424.
45. Hoes, M. J., Vree, T. B. and Guelen, P. J. (1981) Circadian rhythm in plasma concentrations of gamma-hydroxybutyric acid in alcoholics. International Journal of the Addictions 16, 1071-1075.
46. Jakobs, C., Bojasch, M., Monch, E., Rating, D., Siemens, H. and Hanefeld, F. (1981) Urinary excretion of gamma-hydroxybutyric acid in a patient with neurological abnormalities. The probability of a new inborn error of metabolism. Clinica Chimica Acta 111, 169-178.
47. Kaufman, E. E. and Nelson, T. (1981) Kinetics of coupled gamma-hydroxybutyrate oxidation and D-glucuronate reduction by an NADP dependent oxidoreductase. Journal of Biological Chemistry 256, 6820-6824.
48. Kerkut, G. A. and Taberner, P. V. (1971) Hypnogenic properties of succinic semialdehyde and its fatty acid derivates. British Journal of Pharmacology 43, 439P-440P.
49. Koob, G. F., Rassnick, S., Heinrichs, S. and Weiss, F. (1994) Alcohol, the reward system and dependence. In Towards a Molecular Basis of Alcohol Use and Abuse, Jansson. B., Jörvall, H., Rydberg, U., Terenius, L. and Vallee, B. L. eds, pp. 103-114. Birkäuser, Basel.
50. Knyshova, S. P. (1968) Biological effect and hygienic significance of 1,4-butynediol and 1,4-butanediol. Hyg Sanit 33, 41-46.
51. Krsiak, M., Novakova, D., Paclt, I. and Ostrovskaya, R. U. (1974) Effect of sodium hydroxybutyrate on behavior of mice after prolonged isolation. Bulletin of Experimental Biology and Medicine 77, 288-291.
52. Laborit, H. (1964) Sodium 4-hydroxybutyrate. International Journal of Neuropharmacology 3, 433-452.
53. 14C-gamma-hydroxy-butyric acid. Research Communications in Chemical Pathology and Pharmacology 13, 425-437.
54. Lettieri, J. T. and Fung, H. (1978) Improved pharmacological activity via pro-drug modification: comparative pharmacokinetics of sodium gamma-hydroxybutyrate and gamma-butyrolactone. Research Communications in Chemical Pathology and Pharmacology 22, 107-118.
55. Liljequist, S. and Engel, J. (1979) The effect of chronic ethanol administration on central neurotransmitter mechanisms. Medical Biology 57, 198-210.
56. Liljequist, S., Berggren, U. and Engel, J. (1980) Effect of ethanol on the central GABAergic mechanism. Drug and Alcohol Dependence 6, 74-75.
57. Liopo, A. V., Bykov, I. L. and Poldrugo, F. (1991) Ethanolamine affects the dynamics of blood endogenous ethanol during the alcohol withdrawal syndrome. Alcoholism: Clinical and Experimental Research 15, 331.
58. Maitre, M. (1997) The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Progress in Neurobiology 51, 337-361.
59. Mamelak, M., Scharf, M. and Woods, M. (1986) Treatment of narcolepsy with gamma-hydroxybutyrate: a review of clinical and sleep laboratory findings. Sleep 9, 285-289.
60. Marcus, R. J., Winters, W. D., Mori, K. and Spooner, C. E. (1967) EEG changes and behavioral comparison of the effects of gamma-hydroxybutyrate, gamma-butyrolactone and short chain fatty acids in the rat. International Journal of Neuropharmacology 6, 175-185.
61. Mattila, M. J., Palva, E., Seppälä, T. and Ostrovskaya, R. U. (1978) Actions and interactions with alcohol of drugs on psychomotor skills: comparison of diazepam and gamma-hydroxybutyric acid. Archives Internationale de Pharmacodynamie et de Therapie 234, 236-246.
62. McCabe, E. R., Layne, E. C., Sayler, D. F., Slusher, N. and Bessman, S. P. (1970) Synergy of ethanol and a natural soporific - gamma-hydroxybutyrate. Science 171, 404-406.
63. McLennan, F. M. and Parry, J. W. L. (1983) Gammahydroxybutyrate. Anaesthesia 38, 598-599.
64. Meldrum, B. (1981) GABA-agonist as anti-epileptic agent. Advances in Biochemical Psvchopharmacology 26, 207-217.
65. Nelson, T., Kaufman, E. E., Kline, J. and Sokoloff, L. (1981) The extraneuronal distribution of gamma-hydroxybutyrate. Journal of Neurochemistry 37, 1345-1348.
66. Nowycky, M. C. and Roth, R. H. (1979) Chronic gamma-butyrolactone (GBL) treatment: a potential model of dopamine hypoactivity. Naunyn-Schmiedeberg's Archives of Pharmacology 309, 247-254.
67. Ostrovsky, Y. M. (1986) Endogenous ethanol - its metabolic, behavioral and biomedical significance. Alcohol 3, 239-247.
68. Ostrovsky, Y. M., Pronko, P. S., Shishkin, S. N., Koleshnikov, V. B. and Volynets, S. I. (1989) An attempt to evaluate diagnostic and prognostic significance of blood endogenous ethanol in alcoholics and their relatives. Alcohol 6, 97-102.
69. Pietruszko, R., Voigtlander, K. and Lester, D. (1978) Alcohol dehydrogenase from human and horse liver - substrate specificity with diols. Biochemical Pharmacology 27, 1296-1297.
70. Poldrugo, F. (1987) Effect of ethanol on brain gamma-hydroxybutyric acid concentration. Alcohol and Alcoholism 22, 227-229.
71. Poldrugo, F. (1997) Integration of pharmacotherapies in the existing programs for the treatment of alcoholics: an international perspective. Journal of Addictive Diseases, 16, 65-82.
72. Poldrugo, F. and Snead, O. C. (1984a) 1,4 Butanediol, gamma-hydroxybutyric acid, and ethanol: relationships and interactions. Neuropharmacology 23, 109-113.
73. Poldrugo, F. and Snead, O. C. (1984b) Endogenous liver gamma-hydroxybutyric acid metabolism in the presence of ethanol. Research Communications in Substance Abuse 5, 261-278.
74. Poldrugo, F. and Snead, O. C. (1985) Effect of ethanol and acetaldehyde on gamma-hydroxybutyric acid in rat brain and liver. Substance and Alcohol Actions/ Misuse 5, 263-271.
75. Poldrugo, F. and Snead, O. C. (1986) 1,4-Butanediol and ethanol compete for degradation in rat brain and liver in vitro. Alcohol 3, 367-370.
76. Poldrugo, F., Snead, O. C. and Barker, S. A. (1985a) Chronic alcohol administration produces an increase in liver 1,4-butanediol concentration. Alcohol and Alcoholism 20, 251-253.
77. Poldrugo, F., Barker, S. A., Basa, M., Mallardi, F. and Snead, O. C. (1985b) Ethanol potentiates the toxic effects of 1,4-butanediol. Alcoholism: Clinical and Experimental Research 9, 493-497.
78. Poldrugo, F., Monti, J. A., Snead, O. C. and Ostrovsky, S. Y. (1989) Characterization of gamma-hydroxybutyric acid and succinic semialdehyde metabolism in rat liver. Doklady Akademii Nauk BSSR 33, 750-753.
79. Poldrugo, F., Bykov, I. and Ostrovsky, S. Y. (1991) Sodium valproate effect on ethanol withdrawal is mediated by endogenous ethanol. Neuroscience Society Abstracts 17, 173.
80. Rinaldi, F., Puca, F. M., Matrosimone, F. and Memoli, G. (1967) Sull'impiego del gamma-idrossibutirato di sodio in terapia psichiatrica. Acta Neurologica 22, 21-41.
81. Roth, R. H. (1970) Formation and regional distribution of gamma-hydroxybutyric acid in mammalian brain. Biochemical Pharmacology 19, 3013-3019.
82. Roth, R. H., Ando, N., Simon, J. R., Bird, E. D. and Gold, B. I. (1979) Gamma-hydroxybutyrate: alterations in endogenous brain levels in Huntington's disease. Advances in Neurology 23, 557-566.
83. Roth, R. H., Doherty, J. D. and Walters, J. R. (1980) Gamma-hydroxybutyrate: a role in the regulation of central dopaminergic neurons. Brain Research 189, 556-560.
84. Santaniello, E., Manzocchi, A. and Tosi, L. (1978) Evaluation of gamma-hydroxybutyrate formed from L-glutamate by mouse brain homogenate. Journal of Neurochemistry 31, 1117-1118.
85. Serebryakov, L. A. (1965) Effect of sodium gamma-hydroxybutyrate combined with anaesthetics. Federation Proceedings [Transl Suppls.] 24, T554-T556.
86. Snead, O. C. (1977) Gamma-hydroxybutyrate. Life Sciences 20, 1935-1944.
87. Snead, O. C. and Bearden, L. J. (1980) Naloxone overcomes the dopaminergic, EEG, and behavioral effects of gamma-hydroxybutyrate. Neurology 30, 832-838.
88. Snead, O. C. and Morley, B. J. (1981) Ontogeny of gamma-hydroxybutyric acid. Regional concentration in developing rat, monkey and human brain. Developmental Brain Research 227, 579-589.
89. Snead, O. C., Yu, R. K. and Huttenlocher, P. R. (1976) Gamma hydroxybutyrate: correlation of serum and cerebrospinal fluid levels with electroencephalographic and behavioral effects. Neurologv 26, 51-56.
90. Snead, O. C., Liu, C. C. and Bearden, L. J. (1982) Studies on the relation of gamma-hydroxybutyric acid (GHB) to gamma-aminobutyric acid (GABA). Evidence that GABA is not the sole source of GHB in rat brain. Biochemical Pharmacology 31, 3917-3923.
91. Snead, O. C., Poldrugo, F. and Barker, S. A. (1986) Presence of 1,4-butanediol in neuronal and extra-neuronal tissue. Neuroscience Society Abstracts 12, 285.
92. Spano, P. F. and Przegalinski, E. (1973) Stimulation of serotonin synthesis by anaesthetic and nonanaesthetic doses of gamma-hydroxybutyrate. Pharmacological Research Communications 5, 55-69.
93. Sprince, H. (1969) Congeners of gamma-hydroxybutyrate in relation to depressant and convulsant activity. Biological Psychiatry 1, 301-315.
94. Tabakoff, B. and von Wartburg, J.-P. (1975) Separation of aldehyde reductase and alcohol dehydrogenase from brain by affinity chromatography: metabolism of succinic semialdehyde and ethanol. Biochemical and Biophysical Research Communications 63, 957-966.
95. Taberner, P. V. (1974) Alcohol dehydrogenase activity in rat brain: evidence for the metabolism of succinic semialdehyde to gamma-hydroxybutyrate. Biochemical Pharmacology 23, 1219-1220.
96. Taberner, P. V., Rick, J. T. and Kerkut, G. A. (1972) Metabolic factors involved in the interaction between pyrazole and butane-1,4-diol and gamma-hydroxybutyric acid. Life Sciences 11, 335-341.
97. Tanaka, Z., Mukai, A., Takayaragi, Y., Muto, A., Mikami, Y., Miyakoshi, T., Araya, M., Ohdaira, T. and Aizawa, H. (1966) Clinical application of 4-hydroxybutyrate sodium and 4-butyrolactone in neuropsychiatric patients. Folia Psychiatrica Neurologica Japonica 20, 9-20.
98. Theorell, H., Yonetani, T. and Sjoberg, B. (1969) On the effects of some heterocyclic compounds on the enzymatic activity of liver alcohol dehydrogenase. Acta Chimica Scandinavica 23, 255-260.
99. Thomas, G., Bonner, S. and Gascoigne, A. (1997) Coma induced by abuse of gama-hydroxybutyrate (GHB or liquid ecstasy): a case report. British Medical Journal 314, 35-36.
100. van Dalen, R., Vree, T. B. and Gimbrere, J. S. F. (1978) The use of butanediol-1,4 as a sedative in man. In Neue Untersuchungen mit Gamma-hydroxibuttersaure, Frey, R. ed., pp. 74-81. Springer, Berlin.
101. Vayer, P., Mandel, P. and Maitre, M. (1987) Gamma-hydroxybutyrate, a possible neurotransmitter. Life Sciences 41, 1547-1557.
102. Vickers, M. (1969) Gammahydroxybutyric acid. International Anesthesia Clinics 7, 75-89.
103. R). Pharmaceutisch Weekblad 110, 1257-1262.
104. Vree, T. B., van der Kleijn, E., van der Bogert, A. G., Hoes, M. and Gimbrere, J. S. F. (1976) Clinical toxicology of central depressant and stimulant drugs. In Clinical Pharmacy and Clinical Pharmacology, Gouveia, W. A., Tognoni, G. and van der Kleijn, E. eds, pp. 67-87. North Holland, Amsterdam.
105. Vree, T. B., Damsma, J., van den Bogert, A. G. and van der Kleijn, E. (1978) Pharmacokinetics of 4-hydroxybutyric acid in man, rhesus monkey and dog. In Neue Untersuchungen mit Gamma-hydroxibuttersaure, Frey, R. ed., pp. 21-39. Springer, Berlin.
106. Walkenstein, S. S., Wieser, R., Gudmundsen, C. and Kimmel, H. (1964) Metabolism of gamma-hydroxybutyric acid, Biochimica et Biophysica Acta 86, 640-642.
107. Walters, J. R. and Roth, R. H. (1977) Gamma-hydroxybutyrate: consideration of endogenous role and therapeutical potential. In Neuroregulators and Psychiatric Disorders, Usdin, E., Hamburg, D. A. and Barchas, J. D., eds, pp. 403-414. Oxford University Press, New York.
108. Winters, W. D. and Spooner, C. E. (1965) Various seizure activities following gamma-hydroxybutyrate. International Journal of Neuropharmacology 4, 197-200.
109. Zolesi, O., Daini, L., Capone, M. R., Aglietti, M., Raimondi, F. and Maremmani, I. (1994) The use of GHB in anticraving therapy. Preliminary experimental data of its use in alcohol and heroin dependence. In Drug Addiction and Related Clinical Problems, pp. 57-62. Springer, Vienna.