Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 9, 2005, Pages 1185-1189

  Choi, Jun Shik ^a   Jin, Ming Ji ^a   Han, Hyo Kyung ^a  

^a Chosun University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; DICLOFENAC; DIFLUNISAL; KETOPROFEN; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 1; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; ARTICLE; CELL MEMBRANE TRANSPORT; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; DRUG ACCUMULATION; DRUG EFFECT; DRUG PENETRATION; DRUG STRUCTURE; DRUG UPTAKE; HUMAN; HUMAN CELL; IC 50; MEMBRANE PERMEABILITY; TRANSPORT KINETICS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOIC ACID; CACO-2 CELLS; CARBON RADIOISOTOPES; DICLOFENAC; DIFLUNISAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; KETOPROFEN; LACTIC ACID; MONOCARBOXYLIC ACID TRANSPORTERS; NAPROXEN; PERMEABILITY;

EID: 25844530789     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.57.9.0013     Document Type: Article

References (23)

1. De Lean, A., Munson, P. J., Rodbard, D. (1978) Simultaneous analysis of families of sigmoidgand assay and physiological dose-response curves. Am. J. Physiol. 235: E97-102
2. Emoto, A., Ushigome, F., Koyabu, N., Kajiya, H., Okabe, K., Satoh, S., Tsukimori, K., Nakano, H., Ohtani, H., Sawada, Y. (2002) H(+)-linked transport of salicylic acid, an NSAID, in the human trophoblast cell line BeWo. Am. J. Physiol. Cell. Physiol. 282: C1064-C1075
3. Enerson, B. E., Drewes, L. R. (2003) Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J. Pharm. Sci. 92: 1531-1544
4. Hadjiagapiou, C., Schmidt, L., Dudeja, P. K., Layden, T. J., Ramaswamy, K. (2000) Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. Am. J. Physiol. Gastrointest Liver Physiol. 279: G775-G780
5. Halestrap, A. P., Meredith, D. (2004) The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447: 619-628
6. Halestrap, A. P., Price, N. T. (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 343: 281-299
7. Juel, C., Halestrap, A. P. (1999) Lactate transporter in skeletal muscle - role and regulation of the monocarboxylate transporter. J. Physiol. 517: 633-642
8. Kang, Y. S., Terasaki, T., Tsuji, A. (1990) Acidic drug transport in vivo through the blood-brain barrier: a role of the transport carrier for monocarboxylic acids. J Pharmacobiodyn. 13: 158-163
9. Konishi, Y., Hagiwara, K., Shimizu, M. (2002) Transepithelial transport of fluorescein in Caco-2 cell monolayers and use of such transport in in vitro evaluation of phenolic acid availability. Biosci. Biotechnol. Biochem. 66: 2449-2457
10. Legen, I., Kristl, A. (2003) pH and energy dependent transport of ketoprofen across rat jejunum in vitro. Eur. J. Pharm. Biopharm. 56: 87-94
11. Li, Y. H., Ito, K., Tsuda, Y., Kohda, R., Yamada, H., Itoh, T. (1999) Mechanism of intestinal absorption of an orally active β-lactam prodrug: uptake and transport of carindacillin in Caco-2 cells. J. Pharmacol. Exp. Ther. 290: 958-964
12. Makuc, J., Cappellaro, C., Boles, E. (2004) Co-expression of a mammalian accessory trafficking protein enables functional expression of the rat MCT1 monocarboxylate transporter in Saccharomyces cerevisiae. FEMS Yeast Res. 4: 795-801
13. Ogihara, T., Tamai, I., Takanaga, H., Sai, Y., Tsuji, A. (1996) Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells. Pharm. Res. 13: 1828-1832
14. Orsenigo, M. N., Tosco, M., Bazzini, C., Laforenza, U., Faelli, A. (1999) A monpcarboxylate transporter MCT1 is located at the basolateral pole of rat jejunum. Exp. Physiol. 84: 1033-1042
15. Poole, R. C., Halestrap, A. P. (1993) Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol. 264: C761-782
16. Ritzhaupt, A., Ellis, A., Hosie, K. B., Shirazi-Beechey, S. P. (1998a) The characterization of butyrate transport across pig and human colonic luminal membrane. J. Physiol. 507: 819-830
17. Ritzhaupt, A., Wood, I. S., Ellis, A., Hosie, K. B., Shirazi-Beechey, S. P. (1998b) Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J. Physiol. 513: 719-732
18. Takagi, M., Taki, Y., Sakane, T., Nadai, T., Sezaki, H., Oku, A., Yamashita, S. (1998) A new interpretation of salicylic acid transport across the lipid bilayer: implications of pH-dependent but not carrier-mediated absorption from the gastrointestinal tract. J. Pharmacol. Exp. Ther. 285: 1175-1180
19. Takanaga, H., Tamai, I., Tsuji, A. (1994) pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells. J. Pharm. Pharmacol. 46: 567-570
20. Tamai, I., Takanaga, H., Maeda, H., Sai, Y., Ogihara, T., Higashida, H., Tsuji, A. (1995a) Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem. Biophys. Res. Commun. 214: 482-489
21. Tamai, I., Takanaga, H., Maeda, H., Ogihara, T., Yoneda, M., Tsuji, A. (1995b) Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharmacol. Res. 12: 1727-1732
22. Tsuji, A., Tamai, I. (1996) Carrier-mediated intestinal transport of drugs. Pharm. Res. 13: 963-977
23. Wu, X., Whitfield, L. R., Stewart, B. H. (2000) Atorvastatin transport in the Caco-2 cell model: contributions of P-glyco-protein and the proton-monocarboxylic acid co-transporter. Pharmacol. Res. 17: 209-215