Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1α mediates estrogen receptor-α-induced mesenchymal stem cell vascular endothelial growth factor production

Journal of Thoracic and Cardiovascular Surgery

Volumn 138, Issue 1, 2009, Pages

  Wang, Meijing ^b   Tan, Jiangning ^b   Coffey, Arthur ^a   Fehrenbacher, John ^a   Weil, Brent R ^b   Meldrum, Daniel R ^a,b  

^a METHODIST HOSPITAL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; STAT3 PROTEIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL CULTURE; CELL EXPANSION; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; KNOCKOUT MOUSE; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING; WILD TYPE;

EID: 67649390844     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2009.03.010     Document Type: Article

References (36)

1. Crisostomo P.R., and Meldrum D.R. Stem cell delivery to the heart: clarifying methodology and mechanism. Crit Care Med 35 (2007) 2654-2656
2. Markel T.A., Wang Y., Herrmann J.L., Crisostomo P.R., Wang M., Novotny N.M., et al. VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function. Am J Physiol Heart Circ Physiol 295 (2008) H2308-H2314
3. Uemura R., Xu M., Ahmad N., and Ashraf M. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res 98 (2006) 1414-1421
4. Lin H., Shabbir A., Molnar M., Yang J., Marion S., Canty Jr. J.M., et al. Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells. J Cell Physiol 216 (2008) 458-468
5. Payne T.R., Oshima H., Okada M., Momoi N., Tobita K., Keller B.B., et al. A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. J Am Coll Cardiol 50 (2007) 1677-1684
6. Wang Y., Haider H.K., Ahmad N., Xu M., Ge R., and Ashraf M. Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair. J Mol Cell Cardiol 40 (2006) 736-745
7. Tang Y.L., Zhao Q., Zhang Y.C., Cheng L., Liu M., Shi J., et al. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept 117 (2004) 3-10
8. Crisostomo P.R., Markel T.A., Wang M., Lahm T., Lillemoe K.D., and Meldrum D.R. In the adult mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power. Surgery 142 (2007) 215-221
9. Erwin G.S., Crisostomo P.R., Wang Y., Wang M., Markel T.A., Guzman M., et al. Estradiol-treated mesenchymal stem cells improve myocardial recovery after ischemia. J Surg Res (2008 Mar 13) Epub ahead of print
10. Leskela H.V., Olkku A., Lehtonen S., Mahonen A., Koivunen J., Turpeinen M., et al. Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts. Bone 39 (2006) 1026-1034
11. Hong L., Colpan A., Peptan I.A., Daw J., George A., and Evans C.A. 17-Beta estradiol enhances osteogenic and adipogenic differentiation of human adipose-derived stromal cells. Tissue Eng 13 (2007) 1197-1203
12. Bulut D., Albrecht N., Imohl M., Gunesdogan B., Bulut-Streich N., Borgel J., et al. Hormonal status modulates circulating endothelial progenitor cells. Clin Res Cardiol 96 (2007) 258-263
13. Martinez-Cerdeno V., Noctor S.C., and Kriegstein A.R. Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex. Eur J Neurosci 24 (2006) 3475-3488
14. Kazi A.A., and Koos R.D. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Endocrinology 148 (2007) 2363-2374
15. Kazi A.A., Jones J.M., and Koos R.D. Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter. Mol Endocrinol 19 (2005) 2006-2019
16. Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., and Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277 (2002) 38205-38211
17. Fukuda R., Kelly B., and Semenza G.L. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res 63 (2003) 2330-2334
18. Richard D.E., Berra E., and Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 275 (2000) 26765-26771
19. Yen M.L., Su J.L., Chien C.L., Tseng K.W., Yang C.Y., Chen W.F., et al. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. Mol Pharmacol 68 (2005) 1061-1073
20. Jung J.E., Lee H.G., Cho I.H., Chung D.H., Yoon S.H., Yang Y.M., et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. Faseb J 19 (2005) 1296-1298
21. Platt D.H., Bartoli M., El-Remessy A.B., Al-Shabrawey M., Lemtalsi T., Fulton D., et al. Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3. Free Radic Biol Med 39 (2005) 1353-1361
22. Gao H., Bryzgalova G., Hedman E., Khan A., Efendic S., Gustafsson J.A., et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol 20 (2006) 1287-1299
23. Wang T.H., Xiang Q.L., Chen J.W., Pan H., and Cui Y.H. Raloxifene plus 17beta-estradiol inhibits proliferation of primary cultured vascular smooth muscle cells and human mammary endothelial cells via the janus kinase/signal transducer and activator of transcription3 cascade. Eur J Pharmacol 561 (2007) 7-13
24. Bjornstrom L., and Sjoberg M. Signal transducers and activators of transcription as downstream targets of nongenomic estrogen receptor actions. Mol Endocrinol 16 (2002) 2202-2214
25. Welte T., Zhang S.S., Wang T., Zhang Z., Hesslein D.G., Yin Z., et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A 100 (2003) 1879-1884
26. Wang M., Zhang W., Crisostomo P., Markel T., Meldrum K.K., Fu X.Y., et al. STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol 42 (2007) 1009-1015
27. Crisostomo P.R., Wang M., Herring C.M., Morrell E.D., Seshadri P., Meldrum K.K., et al. Sex dimorphisms in activated mesenchymal stem cell function. Shock 26 (2006) 571-574
28. Bi R., Broutman G., Foy M.R., Thompson R.F., and Baudry M. The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus. Proc Natl Acad Sci U S A 97 (2000) 3602-3607
29. Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Koos R.D., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16 (1996) 4604-4613
30. Jiang B.H., Agani F., Passaniti A., and Semenza G.L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57 (1997) 5328-5335
31. Niu G., Wright K.L., Huang M., Song L., Haura E., Turkson J., et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21 (2002) 2000-2008
32. Wei D., Le X., Zheng L., Wang L., Frey J.A., Gao A.C., et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22 (2003) 319-329
33. Gao H., Falt S., Sandelin A., Gustafsson J.A., and Dahlman-Wright K. Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver. Mol Endocrinol 22 (2008) 10-22
34. Osugi T., Oshima Y., Fujio Y., Funamoto M., Yamashita A., Negoro S., et al. Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart. J Biol Chem 277 (2002) 6676-6681
35. Xu Q., Briggs J., Park S., Niu G., Kortylewski M., Zhang S., et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24 (2005) 5552-5560
36. Gray M.J., Zhang J., Ellis L.M., Semenza G.L., Evans D.B., Watowich S.S., et al. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 24 (2005) 3110-3120