Ionically crosslinked chitosan nanoparticles as gene delivery systems: Effect of PEGylation degree on in vitro and in vivo gene transfer

Journal of Biomedical Nanotechnology

Volumn 5, Issue 2, 2009, Pages 162-171

  Csaba, Noemi ^a   Köping Höggård, Magnus ^a   Fernandez Megia, Eduardo ^a   Novoa Carballal, Ramon ^a   Riguera, Ricardo ^a   Alonso, Maria Jose ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Chitosan; Gene delivery; Nanoparticles; Polyethylene glycol; Vaccine

Indexed keywords

ASSOCIATION EFFICIENCY; CELLULAR TOXICITIES; COMBINED EFFECT; CROSS LINKED CHITOSAN; CROSSLINKED; CROSSLINKER; GENE CARRIER; GENE DELIVERY; GENE DELIVERY SYSTEMS; GENE EXPRESSION LEVELS; HIGH MOLECULAR WEIGHT; HIGH STABILITY; IN-VITRO; IN-VIVO; LONG LASTING; LOW MOLECULAR WEIGHT CHITOSANS; NASAL ADMINISTRATION; PARTICLE FORMATIONS; PEGYLATION; PHYSICOCHEMICAL PROPERTY; POLYANIONIC; POSITIVE EFFECTS; TRIPOLYPHOSPHATE;

BIOACTIVITY; BIOLOGICAL MEMBRANES; CHITIN; CHITOSAN; CROSSLINKING; DNA; ETHYLENE GLYCOL; GENE EXPRESSION; GENE TRANSFER; HYDROGELS; MOLECULAR WEIGHT; MULTILAYERS; NANOPARTICLES; NUCLEIC ACIDS; PH EFFECTS; POLYETHYLENE OXIDES; THERMOPLASTICS; TOXICITY;

POLYETHYLENE GLYCOLS;

CHITOSAN; CHITOSAN NANOPARTICLE; DNA; MACROGOL; NANOCARRIER; NANOMATERIAL; NANOPARTICLE; PLASMID DNA; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DEPOLYMERIZATION; DRUG DELIVERY SYSTEM; DRUG SCREENING; DRUG STABILITY; ENCAPSULATION; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TRANSFER; GENETIC ASSOCIATION; GENETIC STABILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NANOENCAPSULATION; NONHUMAN; PH; PHYSICAL CHEMISTRY;

CELL LINE; CHITOSAN; CROSS-LINKING REAGENTS; DNA; DRUG CARRIERS; DRUG COMPOUNDING; GENE TARGETING; HUMANS; IONS; KIDNEY; MATERIALS TESTING; NANOSTRUCTURES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SURFACE PROPERTIES; TRANSFECTION;

EID: 67649366349     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2009.1017     Document Type: Article

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