Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis

FASEB Journal

Volumn 23, Issue 6, 2009, Pages 1739-1749

  Lee, Junghee ^a,b,d   Kannagi, Mari ^c   Ferrante, Robert J ^a,b   Kowall, Neil W ^a,b   Ryu, Hoon ^a,b,d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d Bedford Veterans Affairs Medical Center ^*  (United States)

Author keywords

Astrocytes; Mitochondria; Motor neurons; Neurodegeneration; Transcription

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; PROTEIN BCL XL; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR ETS 2; TRANSCRIPTION FACTOR SP1; PROTEIN BCL X; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL DEATH; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GLIA CELL; IMMUNOREACTIVITY; MALE; MOTONEURON; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SPINAL CORD VENTRAL HORN; ANIMAL; CYTOLOGY; DISEASE MODEL; FEMALE; GENETICS; GLIA; HUMAN; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE; TRANSGENIC MOUSE;

MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BCL-X PROTEIN; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NEUROGLIA; NF-KAPPA B; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEIN C-ETS-2; RNA INTERFERENCE; SP1 TRANSCRIPTION FACTOR; SUPEROXIDE DISMUTASE;

EID: 67649311947     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-121046     Document Type: Article

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