The Ets2 transcription factor inhibits apoptosis induced by colony- stimulating factor 1 deprivation of macrophages through a Bcl-x(L)-dependent mechanism

Molecular and Cellular Biology

Volumn 19, Issue 4, 1999, Pages 2624-2634

  Sevilla, Lidia ^a   Aperlo, Christel ^a,c   Dulic, Vjekoslav ^b   Chambard, Jean Claude ^a   Boutonnet, Christel ^a,d   Pasquier, Olivier ^a   Pognonec, Philippe ^a   Boulukos, Kim E ^a  

^a CENTRE DE BIOCHIMIE   (France)

^b Centre National de la Recherche Scientifique   (France)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; PROTEIN BCL 2; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL SPECIFICITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0032935396     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.4.2624     Document Type: Article

References (53)

1. Aperlo, C., K. E. Boulukos, J. Sage, F. Cuzin, and P. Pognonec. 1996. Complete sequencing of the murine USF gene and comparison of its genomic organization to that of mF1P/USF2. Genomics 37:337-344.
2. Aperlo, C., and K. E. Boulukos. Unpublished data.
3. Aperlo, C., P. Pognonec, E. R. Stanley, and K. E. Boulukos. 1996. Constitutive c-ets2 expression in M1D+ myeloblast leukemic cells induces their differentiation to macrophages. Mol. Cell. Biol. 16:6851-6858.
4. Baccarini, M., D. M. Sabatini, H. App. U. R. Rapp, and E. R. Stanley. 1990. Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J. 9:3649-3657.
5. Bhat, N. K., R. J. Fisher, S. Fujiwara, R. Ascione, and T. S. Papas. 1987. Temporal and tissue-specific expression of mouse ets genes. Proc. Natl. Acad. Sci. USA 84:3161-3165.
6. Boise, L. H., M. Gonzalez-Garcia, C. E. Postema, L. Ding, T. Lindsten, L. A. Turka, X. Mao, G. Nunez, and C. B. Thompson. 1993. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608.
7. Bories, J. C., D. M. Willerford, D. Grevin, L. Davidson, A. Camus, P. Martin, D. Stehelin, and F. W. Alt. 1995. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the ets-1 proto-oncogene. Nature 377:635-638.
8. Boulukos, K. E., P. Pognonec, A. Begue, J. C. Gesquière, D. Stéhelin, and J. Ghysdael. 1988. Identification in chickens of an evolutionary conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene. EMBO J. 7:697-705.
9. Boulukos, K. E., P. Pognonec, B. Rabault, A. Begue, and J. Ghysdael. 1989. Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro. Mol. Cell. Biol. 9:5718-5721.
10. Boulukos, K. E., P. Pognonec, E. Sariban, M. Bailly, C. Lagrou, and J. Ghysdael. 1990. Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators. Genes Dev. 4:401-409.
11. Büscher, D., P. Dello Sbarba, R. A. Hipskind, U. R. Rapp, E. R. Stanley, and M. Baccarini. 1993. v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation. Oncogene 8:3323-3332.
12. Büscher, D., R. A. Hipskind, S. Krautwald, T. Reimann, and M. Baccarini. 1995. Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol. Cell. Biol. 15:466-475.
13. Chatterjee, D., Z. Han, J. Mendoza, L. Goodglick, E. A. Hendrickson, P. Pantazis, and J. H. Wyche. 1997. Monocytic differentiation of HL-60 promyelocytic leukemia cells correlates with the induction of Bcl-xL. Cell Growth Differ. 8:1083-1089.
14. Chen, A. Q., L. A. Burdett, A. K. Seth, J. A. Lautenberger, and T. S. Papas. 1990. Requirement of ets-2 expression for Xenopus oocyte maturation. Science 250:1416-1418.
15. DeCaprio, J. A., Y. Furukawa, F. Ajchenbaum, J. D. Griffin, and D. M. Livingston. 1992. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc. Natl. Acad. Sci. USA 89:1795-1798.
16. Dulic, V., L. F. Drullinger, E. Lees, S. I. Reed, and G. H. Stein. 1993. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc. Natl. Acad. Sci. USA 90:11034-11038.
17. 2/M-phase transition. Mol. Cell. Biol. 18:546-557.
18. Fang, W., J. J. Rivard, D. L. Mueller, and T. W. Behrens. 1994. Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes. J. Immunol. 153:4388-4398.
19. Galang, C. K., C. J. Der, and C. A. Hauser. 1994. Oncogenic ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene 9:2913-2921.
20. c-ets. EMBO J. 5:2251-2256.
21. Ghysdael, J., A. Gegonne, P. Pognonec, D. Dernis, D. Leprince, and D. Stehelin. 1986. Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene encoded Mr 54,000 cytoplasmic protein. Proc. Natl. Acad. Sci. USA 83-1714-1718.
22. Gibson, L., S. P. Holmgreen, D. C. S. Huang, O. Bernard, N. G. Copeland, N. A. Jenkins, G. R. Sutherland, E. Baker, J. M. Adams, and S. Cory. 1996. bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene 13:665-675.
23. Gonzalez-Garcia, M., R. Perez-Ballestero, L. Ding, L. Duan, L. H. Boise, C. B. Thompson, and G. Nunez. 1994. bcl-XL is the major bcl-x mRNA form expressed during mouse development and its product localizes in mitochondria. Development 120:3033-3042.
24. Grillot, D. A., M. Gonzalez-Garcia, D. Ekhterae, L. Duan, N. Inohara, S. Ohta, M. F. Seldin, and G. Nunez. 1997. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J. Immunol. 158:4750-4757.
25. Huang, C-C., T. K. Papis, and N. K. Bhat. 1997. A variant form of Ets1 induces apoptosis in human colon cancer cells. Oncogene 15:851-856.
26. Jin, D. I., S. B. Jameson, M. A. Reddy, D. Schenkman, and M. C. Ostrowski. 1995. Alterations in differentiation and behavior of monocytic phagocytes in transgenic mice that express dominant suppressors of ras signaling. Mol. Cell. Biol. 15:693-703.
27. Kitagawa, M., H. Higashi, H. K. Jung, I. Suzuki-Takahashi, M. Ikeda, K. Tamai, J. Kato, K. Segawa, E. Yoshida, S. Nishimura, and Y. Taya. 1996. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15:7060-7069.
28. Kozopas, K. M., T. Yaug, H. L. Buchan, P. Zhou, and R. W. Craig. 1993. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. USA 90:3516-3520.
29. Langer, S. J., D. M. Bortner, M. F. Roussel, C. J. Sherr, and M. C. Ostrowski. 1992. Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. Mol. Cell. Biol. 12:5355-5362.
30. Leprince, D., A. Gegonne, J. Coll, C. DeTaisne, A. Schneeberger, C. Lagrou, and D. Stéhelin. 1983. A putative second cell-derived oncogene of the avian leukemia retrovirus E26. Nature 306:395-397.
31. Lin, E. Y., A. Orlofsky, H. G. Wang, J. C., Reed, and M. B. Prystowsky. 1996. A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. Blood 87:983-992.
32. Lotem, J., and L. Sachs. 1995. Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone. Cell Growth Differ. 6:647-653.
33. Maroulakou, I. G., T. S. Papas, and J. E. Green. 1994. Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis. Oncogene 9:1551-1565.
34. Meyer, D., M. Duriiat, F. Senan, M. Wolff, M. Andre, J. Hourdry, and P. Remy. 1997. Ets-1 and Ets-2 proto-oncogenes exhibit differential and restricted expression patterns during Xenopus laevis oogenesis and embryogenesis. Int. J. Dev. Biol. 41:607-620.
35. Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980-988.
36. Morgan, C., J. W. Pollard, and E. R. Stanley. 1987. Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5. J. Cell. Physiol. 130:420-427.
37. Muthusamy, N., K. Barton, and J. M. Leiden. 1995. Defective activation and survival of T cells lacking the ets-1 transcription factor. Nature 377:639-642.
38. Nunn, M. F., P. M. Seeburg, C. Moscovici, and P. H. Duesberg. 1983. Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature 306:391-395.
39. Packham, G., E. L. White, C. M. Eischen, H. Yang, E. Parganas, J. N. Ihle, D. A. M. Grillot, G. P. Zambetti, G. Nunez, and J. L. Cleveland. 1998. Selective regulation of Bcl-xL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. Genes Dev. 12:2475-2487.
40. Pognonec, P., K. E. Boulukos, C. Aperlo, M. Fujimato, H. Ariga, A. Nomoto, and H. Kato. 1997. Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. Oncogene 14: 2091-2098.
41. Quandt, K., K. Frech, H. Karas, E. Wingender, and T. Werner. 1995. MatInd and MatInspector - new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23:4878-4884.
42. Roussel, M. F., J. L. Cleveland, S. A. Shurtleff, and C. J. Sherr. 1991. Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling. Nature 353:361-363.
43. Schall, T. J., M. Lewis, K. J. Koller, A. Lee, G. C. Rice, G. H. W. Wong, T. Gatanaga, G. A. Granger, R. Lentz, H. Raab, W. J. Kohr, and D. V. Goeddel. 1990. Molecular cloning and expression of a receptor for human tumor necrosis factor. Cell 61:361-370.
44. Shiraiwa, N., N. Inohara, S. Okada, M. Yuzaki, S.-I. Shoji, and S. Ohta. 1996. An additional form of Rat Bcl-x, Bcl-xβ, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. J. Biol. Chem. 271:13258-13265.
45. Stanley, E. R. 1985. The macrophage colony-stimulating factor, CSF-1. Methods Enzymol. 116:565-587.
46. Sumarsono, S. H., T. Wilson, M. J. Tymms, D. J. Venter, C. M. Corrick, R. Kola, M. H. Lahoud, T. S. Papas, A. Seth, and I. Kola. 1996. Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice. Nature 379: 534-537.
47. Tran Quang, C., O. Wessely, M. Pironin, H. Beug, and G. Ghysdael. 1997. Cooperation of Spi-1/PU-1 with an activated erthyrpoietin receptor inhibits apoptosis and Epo-dependent differentiation in primary erthyroblasts and induces their Kit ligand-dependent proliferation. EMBO J. 16:5639-5653.
48. Vincent, S., L. Marty, and P. Fort. 1993. S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eukaryotic cells and tissues. Nucleic Acids Res. 21:1498.
49. Wasylyk, B., S. L. Hahn, and A. Giovane. 1993. The Ets family of transcription factors. Eur. J. Biochem. 211:7-18.
50. Watson, D. K., M. J. McWilliams, P. Lapis, J. A. Lautenberger, C. W. Schweinfest, and T. S. Papas. 1988. Mammalian ets-1 and ets-2 genes encode highly conserved proteins. Proc. Natl. Acad. Sci. USA 85:7862-7866.
51. Watson, D. K., M. J. McWilliams-Smith, M. F. Nunn, P. H. Duesberg, S. J. O'Brien, and T. S. Papas. 1985. The ets sequence from the transforming gene of avian erythroblastosis. Proc. Natl. Acad. Sci. USA 82:7294-7298.
52. Yamamoto, H., M. L. Flannery, S. Kupriyanov, J. Pearce, S. R. McKercher, G. W. Henkel, R. A. Maki, Z. Werb, and R. G. Oshima. 1998. Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev. 12:1315-1326.
53. Yi, H., Y. Fujimura, M. Ouchida, D. D. K. Prasad, V. N. Rao, and E. S. P. Reddy. 1997. Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias. Oncogene 14:1259-1268.