Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: A randomized placebo-controlled study

Journal of the American Geriatrics Society

Volumn 53, Issue 10, 2005, Pages 1658-1666

  Kalisvaart, Kees J ^a   De Jonghe, Jos F M ^a   Bogaards, Marja J ^b   Vreeswijk, Ralph ^a   Egberts, Toine C G ^c   Burger, Bart J ^a   Eikelenboom, Piet ^d,e   Van Gool, Willem A ^d  

^a Location Alkmaar   (Netherlands)

^b REINIER DE GRAAF HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Assessment of delirium; Delirium prevention; Delirium severity; Duration of hospital stay; Elderly; Haloperidol; Orthopedic surgery; Prophylaxis; Risk factors

Indexed keywords

HALOPERIDOL;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELIRIUM; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; GERIATRIC CARE; HIP SURGERY; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL SCHOOL; POSTOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

AGED; AGED, 80 AND OVER; ANTIPSYCHOTIC AGENTS; DELIRIUM; DOUBLE-BLIND METHOD; FEMALE; HALOPERIDOL; HIP FRACTURES; HUMANS; MALE; MENTAL STATUS SCHEDULE; OSTEOARTHRITIS, HIP; OUTCOME ASSESSMENT (HEALTH CARE); POSTOPERATIVE COMPLICATIONS; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; TREATMENT OUTCOME;

EID: 30944447824     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2005.53503.x     Document Type: Article

References (37)

1. Dyer CB, Ashton CM, Teasdale TA. Postoperative delirium. A review of 80 primary data-collection studies. Arch Intern Med 1995;155:461-465.
2. Galanakis P, Bickel H, Gradinger R et al. Acute confusional state in the elderly following hip surgery: Incidence, risk factors and complications. Int J Geriatr Psychiatry 2001;16:349-355.
3. Lindesay J, Rockwood K, Rolfson DB. The epidemiology of delirium. In: Lindesay J, Rockwood K, Macdonald AJ, eds. Delirium in Old Age, 1st Ed. New York: Oxford University Press, 2002, pp 27-50.
4. Marcantonio ER, Flacker JM, Michaels M et al. Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc 2000;48:618-624.
5. Marcantonio ER, Simon SE, Bergmann MA et al. Delirium symptoms in post-acute care: Prevalent, persistent, and associated with poor functional recovery. J Am Geriatr Soc 2003;51:4-9.
6. McCusker J, Cole MG, Dendukuri N et al. Does delirium increase hospital stay? J Am Geriatr Soc 2003;51:1539-1546.
7. O'Keeffe S, Lavan J. The prognostic significance of delirium in older hospital patients. J Am Geriatr Soc 1997;45:174-178.
8. Berggren D, Gustafson Y, Erikson B. Postoperative confusion after anaesthesia in elderly patients with femoral neck fractures. Anesth Analg 1987;66:497-504.
9. Williams-Russo P, Urquhart BL, Sharrock NE et al. Post-operative delirium: Predictors and prognosis in elderly orthopedic patients. J Am Geriatr Soc 1992;40:759-767.
10. Inouye SK, Viscoli CM, Horwitz RI et al. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med 1993;119:474-481.
11. Cole MG, Primeau FJ, Elie LM. Delirium: Prevention, treatment, and outcome studies. J Geriatr Psychiatry Neurol 1998;11:126-137.
12. Inouye SK, Bogardus ST Jr, Charpentier PA et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 1999;340:669-676.
13. Marcantonio ER, Flacker JM, Wright RJ et al. Reducing delirium after hip fracture: A randomized trial. J Am Geriatr Soc 2001;49:516-522.
14. Milisen K, Foreman MD, Abraham IL et al. A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. J Am Geriatr Soc 2001;49:523-532.
15. O'Keeffe S. The prevention of delirium. In: Lindesay J, Rockwood K, Macdonald AJ, eds. Delirium in Old Age, 1st Ed. New York: Oxford University Press, 2002, pp 153-185.
16. Cole MG, Primeau F, McCusker J. Effectiveness of interventions to prevent delirium in hospitalized patients: A systematic review. Can Med Assoc J 1996;155:1263-1268.
17. Practice guideline for the treatment of patients with delirium. American Psychiatric Association. Am J Psychiatry 1999;156:1-20.
18. Kaneko T, Cai J, Ishikura T et al. Prophylactic consecutive administration of haloperidol can reduce the occurrence of postoperative delirium in gastrointestinal surgery. Yonaga Acta Med 1999;42:179-184.
19. Ikarashi Y, Takahashi A, Ishimaru H et al. Suppression of cholinergic activity via the dopamine D2 receptor in the rat striatum. Neurochem Int 1997;30:191-197.
20. Ikarashi Y, Takahashi A, Ishimaru H et al. Regulation of dopamine D1 and D2 receptors on striatal acetylcholme release in rats. Brain Res Bull 1997;43:107-115.
21. Itil T, Fink M. Anticholinergic drug-induced delirium: Experimental modification, quantitative EEG and behavioral correlations. J Nerv Ment Dis 2004;143:492-507.
22. Platt MM, Breitbart W, Smith M et al. Efficacy of neuroleptipcs for hypoactive delirium. J Neuropsych Clin Noeurosc 2004;6:66-67.
23. Cummings JL. Physostigmine ameliorates the delusions of Alzheimer's disease. Biol Psychiatry 1993;33:536-541.
24. Hassan E, Fontaine DK, Nearman HS. Therapeutic considerations in the management of agitated or delirious critically ill patients. Pharmacotherapy 1998;18:113-129.
25. Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA 1996;275:852-857.
26. Knaus WA, Draper EA, Wagner DP et al. APACHE II. A severity of disease classification system. Crit Care Med 1985;13:818-829.
27. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
28. Jorm AF, Jacomb PA. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): Socio-demographic correlates, reliability, validity and some norms, Psychol Med 1989;19:1015-1022.
29. Hetherington R. The Snellen chart as a test of visual acuity. Psychol Forsch 1954;24:349-357.
30. Yesavage JA, Brink TL, Rose TL et al. Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 1982;17:37-49.
31. Mahoney FI, Barthel DW. Functional evaluation: The Barthel index. Md State Med J 1965;14:61-65.
32. Barnes TR. A rating scale for drug-induced akathisia. Br J Psychiatry 1989;154:672-676.
33. Diagnostic and Statistical Manual of Mental Disorders, 4th Ed., Text Revision. Washington, DC: American Psychiatric Association, 2000.
34. Inouye SK, van Dyck CH, Alessi CA et al. Clarifying confusion: The confusion assessment method. A new method for detection of delirium. Ann Intern Med 1990;113:941-948.
35. Trzepacz PT, Baker RW, Greenhouse J. A symptom rating scale for delirium. Psychiatry Res 1988;23:89-97.
36. Cummings JL. Clinical Neuropsychiatry. Orlando, FL: Grune & Stratton, 1985.
37. Breitbart W, Marotta R, Platt MM et al. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry 1996;153:231-237.