Hormones and adult neurogenesis in mammals

Expert Review of Endocrinology and Metabolism

Volumn 2, Issue 2, 2007, Pages 261-276

  Richardson, Samantha J ^a   Almeida, Osborne F X ^b   Demeneix, Barbara A ^a  

^a CNRS   (France)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Adult neurogenesis; Hippocampus; Hormones; Mammals; Subventricular zone

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ANDROSTANOLONE; CELL NUCLEUS RECEPTOR; ESTRADIOL; ESTRIOL; ESTROGEN; ESTRONE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INSULIN; LIOTHYRONINE; MINERALOCORTICOID RECEPTOR; NERVE CELL ADHESION MOLECULE; NESTIN; PRASTERONE SULFATE; PREGNENOLONE SULFATE; PROGESTERONE; PROLACTIN; SOMATOMEDIN C; TESTOSTERONE; THYROID HORMONE; THYROXINE; TRANSCRIPTION FACTOR SOX2;

AGING; ALZHEIMER DISEASE; ASTROCYTE; BEHAVIOR; BRAIN REGION; CELL RENEWAL; CELLULAR DISTRIBUTION; COGNITIVE DEFECT; CYTOLOGY; DEGENERATIVE DISEASE; DEPRESSION; DISEASE ASSOCIATION; DRUG MECHANISM; DRUG TARGETING; EMBRYONIC STEM CELL; HIPPOCAMPUS; HORMONE ACTION; HUMAN; HUNTINGTON CHOREA; HYPOTHYROIDISM; LEARNING; MAMMAL; MARMOSET; MEDICAL RESEARCH; MEMORY CONSOLIDATION; MONKEY; MOOD; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROBLAST; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; REVIEW; SCANDENTIA; SMELLING; SUBVENTRICULAR ZONE; TISSUE SPECIFICITY; TOTIPOTENT STEM CELL;

EID: 67649201017     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/17446651.2.2.261     Document Type: Review

References (144)

1. Altman J. Are new neurons formed in the brains of adult mammals? Science 135, 1127-1128 (1962).
2. Nottebohm F. Neuronal replacement in adult brain. Brain Res. Bull. 57(6), 737-749 (2002).
3. Arnold AP, Nottebohm F, Pfaff DW. Hormone concentrating cells in vocal control and other areas of the brain of the zebra finch (Poephila guttata) Comp. Neurol. 165(4), 487-511(1976).
4. Rasika S, Nottebohm F, Alvarez-Buylla A. Testosterone increases the recruitment and/or survival of new high vocal center neurons in adult female canaries. Proc. Natl Acad. Sci. USA 91(17), 7854-7858 (1994).
5. Goldman SA, Nottebohm F. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain. Proc. Natl Acad. Sci. USA 80(8), 2390-2394 (1983).
6. Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97(6), 703-716 (1999).
7. Louissaint A Jr, Rao S, Leventhal C, Goldman SA. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34(6), 945-960 (2002).
8. Fuchs E, Flugge G, Czeh B. Remodeling of neuronal networks by stress. Front Biosci. 11, 2746-2758 (2006).
9. Seri B, Herrera DG, Gritti A et al. Composition and organization of the SCZ: a large germinal layer containing neural stem cells in the adult mammalian brain. Cereb. Cortex 16(Suppl. 1), 1103-1111 (2006).
10. Lois C, Garcia-Verdugo JM, Alvarez-Buylla A. Chain migration of neuronal precursors. Science 271(5251), 978-981 (1996).
11. Gould E, Reeves AJ, Graziano MS, Gross CG. Neurogenesis in the neocortex of adult primates. Science 286(5439), 548-552 (1999).
12. Hagg T. Molecular regulation of adult CNS neurogenesis: an integrated view. Trends Neurosci. 28(11), 589-595 (2005).
13. Sawamoto K, Wichterle H, Gonzalez-Perez O et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311(5761), 629-632 (2006).
14. Hoglinger GU, Rizk P, Muriel MP et al. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat. Neurosci. 7(7), 726-735 (2004).
15. Morshead CM, van der Kooy D. Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain. J. Neurosci. 12(1), 249-256 (1992).
16. Shingo T, Gregg C, Enwere E et al. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 299(5603), 117-120 (2003).
17. Lemkine GF, Raj A, Alfama G et al. Adult neural stem cell cycling in vivo requires thyroid hormone and its a receptor. FASEB J. 19(7), 863-865 (2005).
18. Jin K, Minami M, Lan JQ et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl Acad. Sci. USA 98(8), 4710-4715 (2001).
19. Alvarez-Buylla A, Garcia-Verdugo JM. Neurogenesis in adult subventricular zone. J. Neurosci. 22(3), 629-634 (2002).
20. van Praag H, Schinder AF, Christie BR et al. Functional neurogenesis in the adult hippocampus. Nature 415(6875), 1030-1034 (2002).
21. Sun W, Winseck A, Vinsant S et al. Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax. J. Neurosci. 24(49), 11205-11213 (2004).
22. Gould E, Tanapat P, Hastings NB, Shors TJ. Neurogenesis in adulthood: a possible role in learning. Trends Cogn. Sci. 3(5), 186-192 (1999).
23. Schinder AF, Gage FH. A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology (Bethesda) 19, 253-261 (2004).
24. Gould E, Tanapat P, Rydel T, Hastings N. Regulation of hippocampal neurogenesis in adulthood. Biol Psychiatry 48(8), 715-720 (2000).
25. Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 124(3), 319-335 (1965).
26. Seri B, Garcia-Verdugo JM, Collado-Morente L, McEwen BS, Alvarez-Buylla A. Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. J. Comp. Neurol. 478(4), 359-378 (2004).
27. Eriksson PS, Perfilieva E, Bjork-Eriksson T et al. Neurogenesis in the adult human hippocampus. Nat. Med. 4(11), 1313-1317 (1998).
28. Kornack DR, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc. Natl Acad. Sci. USA 96(10), 5768-5773 (1999).
29. Gould E, Reeves AJ, Fallah M et al. Hippocampal neurogenesis in adult Old World primates. Proc. Natl Acad. Sci. USA 96(9), 5263-5267 (1999).
30. Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl Acad. Sci. USA 95(6), 3168-3171 (1998).
31. Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J. Neurosci. 17(7), 2492-2498 (1997).
32. Ming GL, Song H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci. 28, 223-250 (2005).
33. Christie BR, Cameron HA. Neurogenesis in the adult hippocampus. Hippocampus 16(3), 199-207 (2006).
34. Reynolds BA, Rietze RL. Neural stem cells and neurospheres - re-evaluating the relationship. Nat. Methods 2(5), 333-336 (2005).
35. Ray J, Gage FH. Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Mol. Cell. Neurosci. 31(3), 560-573 (2006).
36. Cameron HA, Woolley CS, Gould E. Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrus. Brain Res. 611(2), 342-346 (1993).
37. Garcia A, Steiner B, Kronenberg G, Bick-Sander A, Kempermann G. Age-dependent expression of glucocorticoid- and mineralocorticoid receptors on neural precursor cell populations in the adult murine hippocampus. Aging Cell 3(6), 363-371 (2004).
38. Lie DC, Song H, Colamarino SA, Ming GL, Gage FH. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu. Rev. Pharmacol. Toxicol. 44, 399-421 (2004).
39. Leuner B, Gould E, Shors TJ. Is there a link between adult neurogenesis and learning? Hippocampus 16(3), 216-224 (2006).
40. Wiskott L, Rasch MJ, Kempermann G. A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus. Hippocampus 16(3), 329-343 (2006).
41. Abrous DN, Koehl M, Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiol. Rev. 85(2), 523-569 (2005).
42. Sapolsky RM. The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. Biol. Psychiatry 48(8), 755-765 (2000).
43. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6(6), 463-475 (2005).
44. Santarelli L, Saxe M, Gross C et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301(5634), 805-809 (2003).
45. Sapolsky RM. Is impaired neurogenesis relevant to the affective symptoms of depression? Biol. Psychiatry 56(3), 137-139 (2004).
46. Moser MB, Moser EI. Functional differentiation in the hippocampus. Hippocampus 8(6), 608-619 (1998).
47. pothuizen HH, Zhang WN, Jongen-Relo AL, Feldon J, Yee BK. Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory. Eur. J. neurosci. 19(3), 705-712 (2004).
48. Silva R, Lu J, Wu Y et al. Mapping cellular gains and losses in the postnatal dentate gyrus: implications for psychiatric disorders. Exp. Neurol. 200(2), 321-331 (2006).
49. Vallee M, Mayo W, Le Moal M. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Res. Brain Res. Rev. 370-3), 301-312 (2001).
50. Tanapat P, Hastings NB, Gould E. Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner. J. Comp. Neurol. 481(3), 252-265 (2005).
51. Galea LA, Spritzer MD, Barker JM, Pawluski JL. Gonadal hormone modulation of hippocampal neurogenesis in the adult. Hippocampus 16(3), 225-232 (2006).
52. Mayo W, Lemaire V, Malaterre J et al. Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus. Neurobiol. Aging 26(1), 103-114 (2005).
53. Galea LA, McEwen BS. Sex and seasonal differences in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles. Neuroscience 89(3), 955-964 (1999).
54. Galea LA, Perrot-Sinal TS, Kavaliers M, Ossenkopp KP. Relations of hippocampal volume and dentate gyrus width to gonadal hormone levels in male and female meadow voles. Brain Res. 821(2), 383-391 (1999).
55. Ormerod BK, Galea LA. Reproductive status influences the survival of new cells in the dentate gyrus of adult male meadow voles. Neurosci. Lett. 346(1-2), 25-28 (2003).
56. Karishma KK, Herbert J. Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression. Eur. J. Neurosci. 16(3), 445-453 (2002).
57. Tanapat P, Hastings NB, Reeves AJ, Gould E. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J. Neurosci. 19(14), 5792-5801 (1999).
58. Ormerod BK Lee TT, Galea LA. Estradiol enhances neurogenesis in the dentate gyri of adult male meadow voles by increasing the survival of young granule neurons. Neuroscience 128(3), 645-654 (2004).
59. Brannvall K, Korhonen L, Lindholm D. Estrogen-receptor-dependent regulation of neural stem cell proliferation and differentiation. Mol. Cell. Neurosci. 21(3), 512-520 (2002).
60. Isgor C, Watson SJ. Estrogen receptor α and β mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone. Neuroscience 134(3), 847-856 (2005).
61. Mazzucco CA, Lieblich SE, Bingham BI et al. Both estrogen receptor α and estrogen receptor β agonists enhance cell proliferation in the dentate gyrus of adult female rats. Neuroscience 141(4), 1793-1800 (2006).
62. Perez-Martin M, Azcoitia I, Trejo JL, Sierra A. Garcia-Segura LM. An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. Eur. J. Neurosci. 18(4), 923-930 (2003).
63. Banasr M, Hery M, Brezun JM, Daszuta A. Serotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrus. Eur. J. Neurosci. 14(9), 1417-1424 (2001).
64. Herrick SP, Waters EM, Drake CT, McEwen BS, Milner TA. Extranuclear estrogen receptor β immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus. Brain Res. 1121(1), 46-58 (2006).
65. Bernal J. Pathophysiology of thyroid hormone deficiency during fetal development. J. Pediatr. Endocrinol. Metab. 18(Suppl. 1), 1253-1256 (2005).
66. Morreale de Escobar G. The role of thyroid hormone in fetal neurodevelopment. J. Pediatr. Endocrinol. Metab. 14(Suppl. 6), 1453-1462 (2001).
67. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Fetal and maternal thyroid hormones. Horm. Res. 26, 12-27 (1987).
68. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Role of thyroid hormone during early brain development. Eur. J. Endocrinol. 151 (Suppl. 3), U25-U37 (2004).
69. Porterfield SP, Hendrich CE. The role of thyroid hormones in prenatal and neonatal neurological development - current perspectives. Endocr. Rev. 14(1), 94-106 (1993).
70. Jackson IM. The thyroid axis and depression. Thyroid 8(10), 951-956 (1998).
71. Haggerty JJ Jr, Prange AJ Jr. Borderline hypothyroidism and depression. Annu. Rev. Med. 46, 37-46 (1995).
72. Haggerty JJ Jr, Stern RA, Mason GA et al. Subdinical hypothyroidism: a modifiable risk factor for depression? Am. J. Psychiatry 150(3), 508-510 (1993).
73. Chan S, Kilby MD. Thyroid hormone and central nervous system development. J. Endocrinol. 165(1), 1-8 (2000).
74. Nunez J, Couchie D, Aniello F, Bridoux AM. Thyroid hormone effects on neuronal differentiation during brain development. Acta Med. Austriaca 19(Suppl. 1), 36-39 (1992).
75. Heuer H, Mason CA. Thyroid hormone induces cerebellar Purkinje cell dendritic development via the thyroid hormone receptor α1. J. Neurosci. 23(33), 10604-10612 (2003).
76. Nicholson JL, Altman J. The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation. Brain Res. 44(1), 13-23 (1972).
77. Madeira MD, Cadete-Leite A, Andrade JP, Paula-Barbosa MM. Effects of hypothyroidism upon the granular layer of the dentate gyrus in male and female adult rats: a morphometric study. J. Comp. Aeurol. 314(1), 171-186 (1991).
78. Rami A, Rabie A, Patel AJ. Thyroid hormone and development of the rat hippocampus: cell acquisition in the dentate gyrus. Neuroscience 19(4), 1207-1216 (1986).
79. Uchida K, Nakamura S, Kobayashi T. Machida T. Topographic analysis of cell proliferation in the hippocampus of the adult mouse. Neuroreport 16(18), 2033-2036 (2005).
80. Trentin AG. Thyroid hormone and astrocyte morphogenesis. J. Endocrinol. 189(2), 189-197 (2006).
81. Bernal J. The significance of thyroid hormone transporters in the brain. Endocrinology 146(4), 1698-1700 (2005).
82. Sugiyama D, Kusuhara H, Taniguchi H et al. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. J. Biol. Chem. 278(44), 43489-43495 (2003).
83. Heuer H, Maier MK, Iden S et al. The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 146(4), 1701-1706 (2005).
84. Leonard JL, Siegrist-Kaiser CA, Zuckerman CJ. Regulation of type II iodothyronine 5′-deiodinase by thyroid hormone. Inhibition of actin polymerization blocks enzyme inactivation in cAMP-stimulated glial cells. J. Biol. Chem. 265(2), 940-946 (1990).
85. Steinsapir J, Harney J, Larsen PR. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J. Clin. Invest. 102(11), 1895-1899 (1998).
86. Clos J, Legrand J. Effects of thyroid deficiency on the different cell populations of the cerebellum in the young rat. Brain Res. 63, 450-455 (1973).
87. Calza L, Fernandez M, Giuliani A, Aloe L, Giardino L. Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. Proc. Natl Acad. Sci. USA 99(5), 3258-3263 (2002).
88. Gould E, Woolley CS, McEwen BS. The hippocampal formation: morphological changes induced by thyroid gonadal and adrenal hormones. Psychoneuroendocrinology 16(1-3), 67-84 (1991).
89. Puymirat J, Miehe M, Marchand R, Sarlieve L, Dussault JH. Immunocytochemical localization of thyroid hormone receptors in the adult rat brain. Thyroid 1(2), 173-184 (1991).
90. Desouza LA, Ladiwala U, Daniel SM et al. Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. Mol. Cell. Neurosci. 29(3), 414-426 (2005).
91. Montero-Pedrazuela A, Venero C, Lavado-Autric R et al. Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior. Mol. Psychiatry 11(4), 361-371 (2006).
92. Ambrogini P, Cuppini R. Ferri P et al. Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 81(4), 244-253 (2005).
93. Bernal J. Thyroid hormones and brain development. Vitam. Horm. 71, 95-122 (2005).
94. Vanderpump MP, Tunbridge WM. Epidemiology and prevention of clinical and subdinical hypothyroidism. Thyroid 12(10), 839-847 (2002).
95. Guadano-Ferraz A, Benavides-Piccione R, Venero C et al. Lack of thyroid hormone receptor α1 is associated with selective alterations in behavior and hippocampal circuits. Mol. Psychiatry 8(1), 30-38 (2003).
96. Venero C, Guadano-Ferraz A, Herrero AI et al. Anxiety memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor α1 can be ameliorated by T3 treatment. Genes Dev. 19(18), 2152-2163 (2005).
97. Duman RS. Depression: a case of neuronal life and death? Biol Psychiatry 56(3), 140-145 (2004).
98. Malberg JE, Duman RS. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28(9), 1562-1571 (2003).
99. Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2(3), 260-265 (1999).
100. Tanapat P, Hastings NB, Rydel TA, Galea LA, Gould E. Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism. J. Comp. Neurol. 437(4), 496-504 (2001).
101. McEwen BS. Stress and hippocampal plasticity. Annu. Rev. Neurosci. 22, 105-122 (1999).
102. Bohn MC, Lauder JM. Cerebellar granule cell genesis in the hydrocortisone-treated rats. Dev. Neurosci. 3(2), 81-89 (1980).
103. DeKosky ST, Nonneman AJ, Scheff SW. Morphologic and behavioral effects of perinatal glucocorticoid administration. Physiol. Behav. 29(5), 895-900 (1982).
104. Yehuda R, Fairman KR, Meyer JS. Enhanced brain cell proliferation following early adrenalectomy in rats. J. Neurochem. 53(1), 241-248 (1989).
105. Gould E, Woolley CS, McEwen BS. Adrenal steroids regulate postnatal development of the rat dentate gyrus: I. Effects of glucocorticoids on cell death. J. Comp. Neurol. 313(3), 479-485 (1991).
106. Sloviter RS, Valiquette G, Abrams GM et al. Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy. Science 243(4890), 535-538 (1989).
107. Cameron HA, Tanapat P, Gould E. Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience, 82(2), 349-354 (1998).
108. Mirescu C, Peters JD, Gould E. Early life experience alters response of adult neurogenesis to stress. Nat. Neurosci. 7(8), 841-846 (2004).
109. Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435(4), 406-417 (2001).
110. Mirescu C, Gould E. Stress and adult neurogenesis. Hippocampus 16(3), 233-238 (2006).
111. Hassan AH, von Rosenstiel P, Patchev VK, Holsboer F, Almeida OF. Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone. Exp. Neurol. 140(1), 43-52 (1996).
112. Almeida OF, Conde GL, Crochemore C et al. Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 14(5), 779-790 (2000).
113. Fischer AK, von Rosenstiel P, Fuchs E et al. The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat. Brain Res. 947(2), 290-293 (2002).
114. Crochemore C, Lu J, Wu Y et al. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol. Psychiatry 10(8), 790-798 (2005).
115. Kim JB, Ju JY, Kim JH et al. Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro. Brain Res. 1027(1-2), 1-10 (2004).
116. Wong EY, Herbert J. Raised circulating corticosterone inhibits neuronal differentiation of progenitor cells in the adult hippocampus. Neuroscience 137(1), 83-92 (2006).
117. Crochemore C, Michaelidis TM, Fischer D, Loeffler JP, Almeida OF. Enhancement of p53 activity and inhibition of neural cell proliferation by glucocorticoid receptor activation. FASEB J. 16(8), 761-770 (2002).
118. Fuchs E, Gould E. Mini-review: in vivo neurogenesis in the adult brain: regulation and functional implications. Eur. J. Neurosci. 12(7), 2211-2214 (2000).
119. Lu J, Goula D, Sousa N, Almeida OF. Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl-D-aspartate receptors. Neuroscience 121(1), 123-131 (2003).
120. Anderson MF, Aberg MA, Nilsson M, Eriksson PS. Insulin-like growth factor-I and neurogenesis in the adult mammalian brain. Brain Res. Dev. Brain Res. 134(1-2), 115-122 (2002).
121. Aberg MA, Aberg ND, Hedbacker H, Oscarsson J, Eriksson PS. Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus. J. Neurosci. 20(8), 2896-2903 (2000).
122. Brooker GJ, Kalloniatis M, Russo VC et al. Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells. J. Neurosci. Res. 59(3), 332-341 (2000).
123. Trejo JL, Carro E, Torres-Aleman I. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J. Neurosci. 21(5), 1628-1634 (2001).
124. Yan YP, Sailor KA, Vemuganti R, Dempsey RJ. Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation. Eur. J. Neurosci. 24(1), 45-54 (2006).
125. Hsieh J, Aimone JB, Kaspar BK et al. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J. Cell Biol. 164(1), 111-122 (2004).
126. Malaterre J, Strambi C, Aouane A et al. Effect of hormones and growth factors on the proliferation of adult cricket neural progenitor cells in vitro. J. Neurobiol. 56(4), 387-397 (2003).
127. Lichtenwalner RJ, Forbes ME, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis. J. Neurosci. Res. 83(2), 199-210 (2006).
128. Sun LY, Evans MS, Hsieh J, Panici J, Bartke A. Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology 146(3), 1138-1144 (2005).
129. Gu W, Brannstrom T, Wester P. Cortical neurogenesis in adult rats after reversible photothrombotic stroke. J. Cereb. Blood Flow Metab. 20(8), 1166-1173 (2000).
130. Jiang W, Gu W, Brannstrom T, Rosqvist R, Wester P. Cortical neurogenesis in adult rats after transient middle cerebral artery occlusion. Stroke 32(5), 1201-1207 (2001).
131. Zhang R, Zhang L, Zhang Z et al. A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats. Ann. Neurol. 50(5), 602-611 (2001).
132. Lichtenwalner RJ, Forbes ME, Bennett SA et al. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107(4), 603-613 (2001).
133. Jacobs BL, Praag H, Gage FH. Adult brain neurogenesis and psychiatry: novel theory of depression. Mol. Psychiatry 5(3), 262-269 (2000).
134. Scharfman HE, Hen R. Neuroscience. Is more neurogenesis always better? Science 315(5810), 336-338 (2007).
135. Ravaglia G, Forti P, Maioli F et al. Blood micronutrient and thyroid hormone concentrations in the oldest-old. J. Clin. Endocrinol. Metab. 85(6), 2260-2265 (2000).
136. Chen RL, Athauda SB, Kassem NA et al. Decrease of transthyretin synthesis at the blood-cerebrospinal fluid barrier of old sheep. J. Gerontol. A Biol. Sci. Med. Sci. 60(7), 852-858 (2005).
137. Cameron HA, McKay RD. Restoring production of hippocampal neurons in old age. Nat. Neurosci. 2(10), 894-897 (1999).
138. Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J. Neurosci. 17(15), 5820-5829 (1997).
139. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16(6), 2027-2033 (1996).
140. Kempermann G, Kuhn HG, Gage FH. Experience-induced neurogenesis in the senescent dentate gyrus. J. Neurosci. 18(9), 3206-3212 (1998).
141. Sonntag WE, Lynch CD, Cefalu WT et al. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. J. Gerontol. A Biol. Sci. Med. Sci. 54(12), B521-B538 (1999).
142. Lai M, Hibberd CJ, Gluckman PD, Seckl JR. Reduced expression of insulin-like growth factor 1 messenger RNA in the hippocampus of aged rats. Neurosci. Lett. 2880), 66-70 (2000).
143. Markowska AL, Mooney M, Sonntag WE. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience 87(3), 559-569 (1998).
144. Lowe WL Jr, Meyer T, Karpen CW, Lorentzen LR. Regulation of insulin-like growth factor I production in rat C6 glioma cells: possible role as an autocrine/paracrine growth factor. Endocrinology 130(5), 2683-2691 (1992).