Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro

Brain Research

Volumn 1027, Issue 1-2, 2004, Pages 1-10

  Kim, Jong Bin ^a   Ju, Jae Yeol ^a   Kim, Ju Hee ^a   Kim, Think You ^a   Yang, Byung Hwan ^a   Lee, Yong Sung ^a   Son, Hyeon ^a  

^a Hanyang University College of Medicine   (South Korea)

Author keywords

Dentate gyrus; Dexamethasone; Hippocampus; Neurogenesis; Rat

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DEXAMETHASONE; MITOGEN ACTIVATED PROTEIN KINASE 1; NUCLEAR PROTEIN; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; HIPPOCAMPUS; INJECTION; INTERMETHOD COMPARISON; MALE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; STEM CELL;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; BROMODEOXYURIDINE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DEXAMETHASONE; DRUG INTERACTIONS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOIDS; HIPPOCAMPUS; HORMONE ANTAGONISTS; IMMUNOHISTOCHEMISTRY; INDOLES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIFEPRISTONE; NEURONS; PHOSPHOPYRUVATE HYDRATASE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS; TIME FACTORS; TRANSFECTION; TUBULIN;

EID: 5644293601     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.07.093     Document Type: Article

References (31)

1. J.M. Adams, and S. Cory The Bcl-2 protein family: arbiters of cell survival Science 281 1998 1322 1326
2. O.F. Almeida, G.L. Conde, C. Crochemore, B.A. Demeneix, D. Fischer, A.H. Hassan, M. Meyer, F. Holsboer, and T.M. Michaelidis Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate FASEB J. 14 2000 779 790
3. P. Ambrogini, L. Orsini, C. Mancini, P. Ferri, I. Barbanti, and R. Cuppini Persistently high corticosterone levels but not normal circadian fluctuations of the hormone affect cell proliferation in the adult rat dentate gyrus Neuroendocrinology 76 2002 366 372
4. A. Basta-Kaim, B. Budziszewska, L. Jaworska-Feil, M. Tetich, M. Leskiewicz, M. Kubera, and W. Lason Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent manner Neuropharmacology 43 2002 1035 1043
5. A. Bruna, M. Nicolas, A. Munoz, J.M. Kyriakis, and C. Caelles Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids EMBO J. 22 2003 6035 6044
6. S.E. Choi, E.Y. Choi, P.H. Kim, and J.H. Kim Involvement of protein kinase C and rho GTPase in the nuclear signalling pathway by transforming growth factor-beta1 in rat-2 fibroblast cells Cell. Signal. 1 1999 71 76
7. C.L. Coe, M. Kramer, B. Czeh, E. Gould, A.J. Reeves, C. Kirschbaum, and E. Fuchs Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys Biol. Psychiatry 54 2003 1025 1034
8. C. Crochemore, T.M. Michaelidis, D. Fischer, J.P. Loeffler, and O.F. Almeida Enhancement of p53 activity and inhibition of neural cell proliferation by glucocorticoid receptor activation FASEB J. 8 2002 761 770
9. S.T. DeKosky, A.J. Nonneman, and S.W. Scheff Morphologic and behavioral effects of perinatal glucocorticoid administration Physiol. Behav. 29 1982 895 900
10. B.J. Deroo, and T.K. Archer Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin Mol. Biol. Cell 11 2001 3365 3374
11. E. Endroczi, M. Sasvary, and J. Simon Effects of glucocorticoid treatment of the carbonic anhydrase activity of brain tissue in the early postnatal age in the rat Acta Physiol. Hung. 3 1994 195 200
12. Y. Engelbrecht, H. de Wet, K. Horsch, C.R. Langeveldt, F.S. Hough, and P.A. Hulley Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines Endocrinology 144 2003 412 422
13. E. Gould, B.S. McEwen, P. Tanapat, L.A. Galea, and E. Fuchs Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation J. Neurosci. 17 1997 2492 2498
14. E. Gould, P. Tanapat, T. Rydel, and N. Hastings Regulation of hippocampal neurogenesis in adulthood Biol. Psychiatry 48 2000 715 720
15. L.E. Haynes, C.L. Lendon, D.J. Barber, and I.J. Mitchell 17 Beta-oestradiol attenuates dexamethasone-induced lethal and sublethal neuronal damage in the striatum and hippocampus Neuroscience 120 2003 799 806
16. K. Ito, P.J. Barnes, and I.M. Adcock Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12 Mol. Cell. Biol. 18 2000 6891 6903
17. G. Kempermann Why new neurons? Possible functions for adult hippocampal neurogenesis J. Neurosci. Rev. 3 2002 635 638
18. J.S. Kim, M.-Y. Chang, I.T. Yu, J.H. Kim, S.-H. Lee, Y.-S. Lee, and H. Son Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo J. Neurochem. 189 2004 324 360
19. J. Lee, W. Duan, and M.P. Mattson Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice J. Neurochem. 82 2002 1367 1375
20. U. Lendahl, L.B. Zimmerman, and R.D. McKay CNS stem cells express a new class of intermediate filament protein Cell 60 1990 585 595
21. O.C. Meijer, and E.R. de Kloet Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity Crit. Rev. Neurobiol. 1-2 1998 1 20
22. A.H. Miller, G.J. Vogt, and B.D. Pearce The phosphodiesterase type 4 inhibitor, rolipram, enhances glucocorticoid receptor function Neuropsychopharmacology 6 2002 939 948
23. K. Muneoka, M. Mikuni, T. Ogawa, K. Kitera, K. Kamei, M. Takigawa, and K. Takahashi Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring Am. J. Physiol. 273 1997 1669 1675
24. C.J. Sherr, and J.M. Roberts CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev. 13 1999 1501 1512
25. T.A. Slotkin, J. Zhang, E.C. McCook, and F.J. Seidler Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids Brain Res. Dev. Brain Res. 111 1998 11 24
26. G.H. Son, D. Geum, H. Jung, and K. Kim Glucocorticoid inhibits growth factor-induced differentiation of hippocampal progenitor HiB5 cells J. Neurochem. 79 2001 1013 1021
27. L.K. Takahashi, and C.S. Goh Glucocorticoid facilitation of cholinergic development in the rat hippocampus Neuroscience 4 1998 1145 1153
28. C.K. Tan, J. Yan, C. Ananth, and C. Kaur Dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats Neurosci. Lett. 3 2002 206 210
29. C.S. Woolley, E. Gould, and B.S. McEwen Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons Brain Res. 531 1990 225 231
30. S.L. Wyszomierski, J. Yeh, and J.M. Rosen Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation Mol. Endocrinol. 2 1999 330 343
31. I.T. Yu, S.H. Lee, Y.S. Lee, and H. Son Differential effects of corticosterone and dexamethasone on hippocampal neurogenesis in vitro Biochem. Biophys. Res. Commun. 317 2004 484 490