Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies

AAPS PharmSciTech

Volumn 10, Issue 2, 2009, Pages 649-659

  Monajjemzadeh, Farnaz ^a   Hassanzadeh, Davoud ^a,c   Valizadeh, Hadi ^a,d   Siahi Shadbad, Mohammad R ^a,d   Mojarrad, Javid Shahbazi ^a,e   Robertson, Thomas ^b   Roberts, Michael S ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Baclofen; Lactose; LC MS MS; Maillard reaction; Solid statein compatibility

Indexed keywords

BACLOFEN; LACTOSE; MAGNESIUM STEARATE; WATER;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG GRANULATION; DRUG STRUCTURE; FEASIBILITY STUDY; GLYCATION; INFRARED SPECTROSCOPY; POLYMERIZATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TABLET FORMULATION; TABLET MANUFACTURE; TANDEM MASS SPECTROMETRY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; TABLET;

BACLOFEN; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LACTOSE; MAILLARD REACTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TANDEM MASS SPECTROMETRY;

EID: 67549122373     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9248-8     Document Type: Article

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