Liquid chromatography-mass spectrometry and proton nuclear magnetic resonance characterization of trace level condensation products formed between lactose and the amine-containing diuretic hydrochlorothiazide

Journal of Pharmaceutical Sciences

Volumn 89, Issue 7, 2000, Pages 920-929

  Harmon, Paul A ^a   Yin, Winnie ^a   Bowen, William E ^a   Tyrrell, R J ^a   Reed, Robert A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amine lactose reactions; Glycosylamines (formation of); Maillard reactions

Indexed keywords

AMINOSUGAR; DIURETIC AGENT; HYDROCHLOROTHIAZIDE; LACTOSE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; DRUG DETERMINATION; DRUG STRUCTURE; GLYCATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0033823179     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200007)89:7<920::AID-JPS9>3.0.CO;2-W     Document Type: Article

References (10)

1. The Maillard reaction in food; a critical review from the nutritional standpoint
2. The Maillard reaction
3. The Amadori rearrangement
4. Comparison of reactivity of amphetamine, methamphetamine, and dimethylamphetamine with lactose and related compounds
5. Interaction of dextroamphetamine sulfate with spray dried lactose
6. Glycosylamines
7. Purification and identification of the dimer impurity in bulk hydrochlorothiazide, manuscript in preparation
8. 1HNMR spectroscopy
9. Hydrochlorothiazide
10. Discoloration of tablets containing amines and lactose