Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice

Journal of Neurochemistry

Volumn 110, Issue 1, 2009, Pages 170-181

  Moriguchi, Shigeki ^a,b   Han, Feng ^a,d   Shioda, Norifumi ^a   Yamamoto, Yui ^a   Nakajima, Takeharu ^c   Nakagawasai, Osamu ^c   Tadano, Takeshi ^c   Yeh, Jay Z ^b   Narahashi, Toshio ^b   Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b NORTHWESTERN UNIVERSITY   (United States)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^d ZHEJIANG UNIVERSITY   (China)

Author keywords

CaM kinase II; Long term potentiation; Metabotropic glutamate receptor; Olfactory bulbectomized mice; Protein kinase C

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 CARBOXY 2 METHYLPHENYLGLYCINE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEFIRACETAM; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; OLFACTORY BULBECTOMY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DENERVATION; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MEMORY DISORDERS; MICE; NOOTROPIC AGENTS; OLFACTORY BULB; ORGAN CULTURE TECHNIQUES; PHOSPHORYLATION; PROTEIN KINASE C; PYRROLIDINONES; RECEPTORS, GLUTAMATE; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

MUS;

EID: 67449152471     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06122.x     Document Type: Article

References (46)

1. Banke T. G., Bowie D., Lee H., Huganir R. L., Schousboe A. Travnelis S. F. (2000) Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. J. Neurosci. 20, 89 102. (Pubitemid 30220495)
2. Barria A., Muller D., Derkach V., Griffith L. C. Soderling T. R. (1997) Regulatory phosphorylation of AMPA-type glutamate receptor by CaMKII during long-term potentiation. Science 276, 2042 2045. (Pubitemid 27443609)
3. Boehm J., Kang M. G., Johnson R. C., Esteban J., Huganir R. L. Malinow R. (2006) Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. Neuron 51, 213 225. (Pubitemid 44041865)
4. Bortolotto Z. A., Collett V. J., Conquet F., Jia Z., van der Putten H. Collingridge G. L. (2005) The regulation of hippocampal LTP by the molecular swith, a form of metaplasticity, requires mGluR5 receptors. Neuropharmacology 49, 13 25. (Pubitemid 41115889)
5. Calabresi P., Gubellini P., Picconi B., Centonze D., Pisani A., Bonsi P., Greengard P., Hipskind R. A., Borrelli E. Bernardi G. (2001) Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogeneous dopamine. J. Neurosci. 21, 5110 5120. (Pubitemid 32622936)
6. Collingridge G. L., Issac J. T. Wang Y. T. (2004) Receptor trafficking and synaptic plasticity. Nat. Rev. Neurosci. 5, 952 962. (Pubitemid 39593358)
7. Corwin J., Serby M., Conrad P. Rotrosen J. (1985) Olfactory recognition deficit in Alzheimer's disease and Parkinsonian dementia. IRCS Med. Sci. 13, 260. (Pubitemid 15144014)
8. 2+/calmodulin- kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionate type glutamate receptors. Proc. Natl Acad. Sci. USA 96, 3269 3274. (Pubitemid 29148880)
9. English J. E. Sweatt J. D. (1996) Activation of p42 mitogen-activated protein kinase in hippocampal long-term potentiation. J. Biol. Chem. 271, 24329 24332.
10. English J. E. Sweatt J. D. (1997) A requirement for the mitogen-activated protein kinase cascade in hippocampal long-term potentiation. J. Biol. Chem. 272, 19103 19106. (Pubitemid 27337694)
11. Esiri M. M. Wilcock G. K. (1984) The olfactory bulbs in Alzheimer's disease. J. Neurol. Neurosurg. Phychiatry 47, 56 60. (Pubitemid 14154239)
12. Francesconi W., Cammalleri M. Sanna P. P. (2004) The metabotripic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res. 1022, 12 18. (Pubitemid 39194979)
13. Frey U., Huang Y. Y. Kandel E. R. (1993) Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260, 1661 1664.
14. Fujimaki Y., Sudo K., Hakusui H., Tachizawa H. Murasaki M. (1992) Single- and multiple-dose pharmacokinetics of nefiracetam, a new nootropic agent, in healthy volunteers. J. Pharm. Pharmacol. 44, 750 754.
15. Fukunaga K. Miyamoto E. (2000) A working model of CaM Kinase II activity in hippocampal long-term potentiation and memory. Neurosci. Res. 38, 3 17. (Pubitemid 30734468)
16. 2+/ calmodulin-dependent protein kinase II. J. Biol. Chem. 268, 7863 7867.
17. 2+/calmodulin-dependent protein kinase II and its endgeneous substrates in the induction of long term potentiation. J. Biol. Chem. 270, 6119 6124.
18. Grosshans D. R., Clayton D. A., Coultrap S. J. Browning M. D. (2002) LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat. Nat. Neurosci. 5, 27 33. (Pubitemid 34038779)
19. Hozumi S., Nakagawasai O., Tan-No K., Niijima F., Yamadera F., Murata A., Arai Y., Yasuhara H. Tadano T. (2003) Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy. Behav. Brain Res. 138, 9 15. (Pubitemid 35463233)
20. 2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 21, 869 883. (Pubitemid 28498794)
21. Kawajiri S., Taniguchi K., Sakurai T., Kojima H. Yamasaki T. (1990) Effect of DM-9384 on extracellular acetylcholine in the rat frontal cortex measured with microdialysis. Eur. J. Pharmacol. 183 (Suppl 928. (Pubitemid 20258299)
22. Koss E. (1986) Olfactory dysfunction in Alzheimer's disease. Dev. Neuropsychol. 2, 89 99.
23. Kovacs T., Cairns N. J. Lantos P. L. (2001) Olfactory centres in Alzheimer's disease: olfactory bulb is involved in early Braak's stage. Neuroreport 12, 285 288. (Pubitemid 32114366)
24. Lee H. K. (2006) Synaptic plasticity and phosphorylation. Pharmacol. Ther. 112, 810 832.
25. Lisman J., Schulman H. Cline H. (2002) The molecular basis of CaMKII function in synaptic and behavioral memory. Nature Rev. Neurosci. 3, 175 190. (Pubitemid 135706588)
26. Lovinger D. M., Wong K. L., Murakami K. Routtenberg A. (1987) Protein kinase C inhibitors eliminate hippocampal long-term potentiation. Brain Res. 436, 177 183. (Pubitemid 17167152)
27. Mammen A. L., Kameyama K., Roche K. W. Huganir R. L. (1997) Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. J. Biol. Chem. 272, 32528 32533. (Pubitemid 28011939)
28. Moriguchi S., Marszalec W., Zhao X., Yeh J. Z. Narahashi T. (2003) Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons. J. Pharmacol. Exp. Ther. 307, 160 167. (Pubitemid 37151902)
29. Moriguchi S., Han F., Nakagawasai O., Tadano T. Fukunaga K. (2006) Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice. J. Neurochem. 97, 22 29.
30. Moriguchi S., Shioda N., Maejima H., Zhao X., Marszalec W., Yeh J. Z., Fukunaga K. Narahashi T. (2007) Nefiracetam potentiates N-methyl-D-aspartate (NMDA) receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor. Mol. Pharmacol. 71, 580 587. (Pubitemid 46147922)
31. Moriguchi S., Shioda N., Han F., Narahashi T. Fukunaga K. (2008) CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region. J. Neurochem. 106, 1092 1103.
32. Nabeshima T., Nakayama S., Ichihara K., Yamada K., Shiotani T. Hasegawa T. (1994) Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task. Eur. J. Pharmacol. 255, 57 65. (Pubitemid 24105744)
33. Nishizaki T., Matsuoka T., Nomura T., Matsuyama S., Watabe S., Shiotani T. Yoshii M. (1999) A 'long-term-potentiation-like' facilitation of hippocampal synaptic transmission induced by the nootropic nefiracetam. Brain Res. 826, 281 288. (Pubitemid 29222942)
34. Ohmitsu M., Fukunaga K., Yamamoto H. Miyamoto E. (1999) Phosphorylation of myristoylated alanine-rich protein kinase C substrate by mitogen-activated protein kinase in cultured rat hippocampal neurons following stimulation of glutamate receptors. J. Biol. Chem. 274, 408 417. (Pubitemid 29035076)
35. Pin J. P. Acher F. (2002) The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr. Drug Targets CNS Neurol. Disord. 1, 297 317.
36. Prickaerts J., Van Staveren W. C. G., Sik A., Markerink-Van Ittersum M., Niewohner U., Van der Staay F. J., Blokland A. De Vente J. (2002) Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat. Neuroscience 113, 349 359.
37. Roche K. W., O'Brien R. J., Mammen A. L., Bernhardt J. Huganir R. L. (1996) Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron 16, 1179 1188. (Pubitemid 26227239)
38. 2+/calmodulin dependent protein kinase II in opioid tolerance and dependence. Neurosci. Lett. 404, 266 269. (Pubitemid 44108438)
39. Skeberdis V. A., Lan J., Optiz T., Zheng X., Bennett M. V. Zukin R. S. (2001) mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C. Neuropharmacology 40, 856 865. (Pubitemid 32510799)
40. Soderling T. R. Derkach V. A. (2000) Postsynaptic protein phosphorylation and LTP. Trends Neurosci. 23, 75 80. (Pubitemid 30084764)
41. Tingley W. G., Ehlers M. D., Kameyama K., Doherty C., Ptak J. B., Riley C. T. Huganir R. L. (1997) Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J. Biol. Chem. 272, 5157 5166. (Pubitemid 27090073)
42. Warner M. D., Peabody C. A., Flattery J. J. Tinklenberg J. R. (1986) Olfactory deficits and Alzheimer's disease. Biol. Psychiatry 2, 116 118. (Pubitemid 16043739)
43. Xia Z. Storm D. R. (2005) The role of calmodulin as a signal integrator for synaptic plasticity. Nat. Rev. Neurosci. 6, 267 276. (Pubitemid 40469981)
44. Yamada K., Tanaka T., Mamiya T., Shiotani T., Kameyama T. Nabeshima T. (1999) Improvement by nefiracetam of β-amyloid-(1-42)-induced learning and memory impairments in rats. Br. J. Pharmacol. 126, 235 244. (Pubitemid 29041763)
45. Yamagata Y. (2003) New aspects of neurotransmitter release and exocytosis: dynamic and differential regulation of synapsin I phosphorylation by acute neuronal excitation in vivo. J. Pharmacol. Sci. 93, 22 29. (Pubitemid 37254262)
46. Zhao X., Kuryatov A., Lindstorm J. M., Yeh J. Z. Narahashi T. (2001) Nootropic drug modulation of neuronal nicotinic acethylcholine receptors in rat cortical neurons. Mol. Pharmacol. 59, 674 683. (Pubitemid 32273995)