Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway

Regulatory Peptides

Volumn 155, Issue 1-3, 2009, Pages 62-69

  Kui, Liu ^a   Weiwei, Zhang ^a   ling, Liu ^a   Daikun, He ^a   Guoming, Zhou ^b   Linuo, Zhou ^a   Renming, Hu ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Cardiomyocytes; Ghrelin; Oxidative stress; PI3K

Indexed keywords

CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; GHRELIN; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART MUSCLE CELL; HEART PROTECTION; MALE; NONHUMAN; ONCOGENE C FOS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GHRELIN; GLUCOSE; MALE; NF-KAPPA B; PALMITIC ACID; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SWEETENING AGENTS;

RATTUS;

EID: 67349227911     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2009.03.003     Document Type: Article

References (56)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
2. Kojima M., and Kangawa K. Ghrelin: structure and function. Physiol Rev 85 (2005) 495-522
3. Gnanapavan S., Kola B., Bustin S.A., Morris D.G., McGee P., Fairclough P., Bhattacharya S., Carpenter R., Grossman A.B., and Korbonits M. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87 (2002) 2988
4. Katugampola S.D., Pallikaros Z., and Davenport A.P. [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis. Br J Pharmacol 134 (2001) 143-149
5. Nagaya N., Kojima M., Uematsu M., Yamagishi M., Hosoda H., Oya H., Hayashi Y., and Kangawa K. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol 280 (2001) R1483-R1487
6. Nagaya N., Moriya J., Yasumura Y., Uematsu M., Ono F., Shimizu W., Ueno K., Kitakaze M., Miyatake K., and Kangawa K. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 110 (2004) 3674-3679
7. Nagaya N., Uematsu M., Kojima M., Ikeda Y., Yoshihara F., Shimizu W., Hosoda H., Hirota Y., Ishida H., Mori H., and Kangawa K. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104 (2001) 1430-1435
8. Joseph J., Koka M., and Aronow W.S. Prevalence of moderate and severe renal insufficiency in older persons with hypertension, diabetes mellitus, coronary artery disease, peripheral arterial disease, ischemic stroke, or congestive heart failure in an academic nursing home. J Am Med Dir Assoc 9 (2008) 257-259
9. Hamby R.I., Zoneraich S., and Sherman L. Diabetic cardiomyopathy. Jama 229 (1974) 1749-1754
10. Kannel W.B., Hjortland M., and Castelli W.P. Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol 34 (1974) 29-34
11. Coughlin S.S., Pearle D.L., Baughman K.L., Wasserman A., and Tefft M.C. Diabetes mellitus and risk of idiopathic dilated cardiomyopathy. The Washington, DC Dilated Cardiomyopathy Study. Ann Epidemiol 4 (1994) 67-74
12. Eichhorn E.J., and Bristow M.R. Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure. Circulation 94 (1996) 2285-2296
13. Beltrami C.A., Finato N., Rocco M., Feruglio G.A., Puricelli C., Cigola E., Sonnenblick E.H., Olivetti G., and Anversa P. The cellular basis of dilated cardiomyopathy in humans. J Mol Cell Cardiol 27 (1995) 291-305
14. Rayment N.B., Haven A.J., Madden B., Murday A., Trickey R., Shipley M., Davies M.J., and Katz D.R. Myocyte loss in chronic heart failure. J Pathol 188 (1999) 213-219
15. Knaapen M.W., Davies M.J., De Bie M., Haven A.J., Martinet W., and Kockx M.M. Apoptotic versus autophagic cell death in heart failure. Cardiovasc Res 51 (2001) 304-312
16. Kang P.M., and Izumo S. Apoptosis and heart failure: a critical review of the literature. Circ Res 86 (2000) 1107-1113
17. Guha A., Harmancey R., and Taegtmeyer H. Nonischemic heart failure in diabetes mellitus. Curr Opin Cardiol 23 (2008) 241-248
18. Tsutsui H. Mitochondrial oxidative stress and heart failure. Intern Med 45 (2006) 809-813
19. O'Connell T.D., Rodrigo M.C., and Simpson P.C. Isolation and culture of adult mouse cardiac myocytes. Methods Mol Biol 357 (2007) 271-296
20. Schluter K.D., and Schreiber D. Adult ventricular cardiomyocytes: isolation and culture. Methods Mol Biol 290 (2005) 305-314
21. Baldanzi G., Filigheddu N., Cutrupi S., Catapano F., Bonissoni S., Fubini A., Malan D., Baj G., Granata R., Broglio F., Papotti M., Surico N., Bussolino F., Isgaard J., Deghenghi R., Sinigaglia F., Prat M., Muccioli G., Ghigo E., and Graziani A. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 159 (2002) 1029-1037
22. Shigenaga M.K., Hagen T.M., and Ames B.N. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A 91 (1994) 10771-10778
23. Boveris A., Valdez L.B., Zaobornyj T., and Bustamante J. Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol. Biochim Biophys Acta 1757 (2006) 535-542
24. Rosen P., Nawroth P.P., King G., Moller W., Tritschler H.J., and Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev 17 (2001) 189-212
25. Sastre J., Pallardo F.V., Garcia de la Asuncion J., and Vina J. Mitochondria, oxidative stress and aging. Free Radic Res 32 (2000) 189-198
26. Bernardi P. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization. J Biol Chem 267 (1992) 8834-8839
27. Maciel E.N., Vercesi A.E., and Castilho R.F. Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria. J Neurochem 79 (2001) 1237-1245
28. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 341 Pt 2 (1999) 233-249
29. Kuethe F., Sigusch H.H., Bornstein S.R., Hilbig K., Kamvissi V., and Figulla H.R. Apoptosis in patients with dilated cardiomyopathy and diabetes: a feature of diabetic cardiomyopathy?. Horm Metab Res 39 (2007) 672-676
30. Shirpoor A., Salami S., Khadem-Ansari M.H., Ilkhanizadeh B., Pakdel F.G., and Khademvatani K. Cardioprotective effect of vitamin E: rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat. J Diabetes its Complicat (2008)
31. Wajant H. The Fas signaling pathway: more than a paradigm. Science 296 (2002) 1635-1636
32. Nithipongvanitch R., Ittarat W., Cole M.P., Tangpong J., Clair D.K., and Oberley T.D. Mitochondrial and nuclear p53 localization in cardiomyocytes: redox modulation by doxorubicin (Adriamycin)?. Antioxid Redox Signal 9 (2007) 1001-1008
33. Maddika S., Ande S.R., Panigrahi S., Paranjothy T., Weglarczyk K., Zuse A., Eshraghi M., Manda K.D., Wiechec E., and Los M. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat 10 (2007) 13-29
34. Cantley L.C. The phosphoinositide 3-kinase pathway. Science (New York, N.Y) 296 (2002) 1655-1657
35. Sussman M. "AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Trends Cardiovasc Med (2007) 235-240
36. d'Anglemont de Tassigny A., Berdeaux A., Souktani R., Henry P., and Ghaleh B. The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2. Eur J Heart Fail 10 (2008) 39-46
37. Liu X.B., Jiang J., Gui C., Hu X.Y., Xiang M.X., and Wang J.A. Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway. Acta Pharmacol Sin 29 (2008) 815-822
38. Martelli A.M., Faenza I., Billi A.M., Manzoli L., Evangelisti C., Fala F., and Cocco L. Intranuclear 3′-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis?. Cell Signal 18 (2006) 1101-1107
39. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., and Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
40. Galetic I., Andjelkovic M., Meier R., Brodbeck D., Park J., and Hemmings B.A. Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase-significance for diabetes and cancer. Pharmacol Ther 82 (1999) 409-425
41. Wu W., Lee W.L., Wu Y.Y., Chen D., Liu T.J., Jang A., Sharma P.M., and Wang P.H. Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells. J Biol Chem 275 (2000) 40113-40119
42. Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., Frisch S., and Reed J.C. Regulation of cell death protease caspase-9 by phosphorylation. Science (New York, N.Y) 282 (1998) 1318-1321
43. Hayden M.S., and Ghosh S. Shared principles in NF-kappaB signaling. Cell 132 (2008) 344-362
44. Chong Z.Z., Li F., and Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 75 (2005) 207-246
45. Samanta A.K., Huang H.J., Bast Jr. R.C., and Liao W.S. Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. J Biol Chem 279 (2004) 7576-7583
46. Kowaltowski A.J., Castilho R.F., and Vercesi A.E. Mitochondrial permeability transition and oxidative stress. FEBS Lett 495 (2001) 12-15
47. Vercesi A.E., Kowaltowski A.J., Oliveira H.C., and Castilho R.F. Mitochondrial Ca2+ transport, permeability transition and oxidative stress in cell death: implications in cardiotoxicity, neurodegeneration and dyslipidemias. Front Biosci 11 (2006) 2554-2564
48. Chong Z.Z., Kang J.Q., and Maiese K. Apaf-1, Bcl-xL, Cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. J Cereb Blood Flow Metab 23 (2003) 320-330
49. Gottlieb E., Vander Heiden M.G., and Thompson C.B. Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 20 (2000) 5680-5689
50. Reed J.C. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med 7 (2001) 314-319
51. Andreis P.G., Malendowicz L.K., Trejter M., Neri G., Spinazzi R., Rossi G.P., and Nussdorfer G.G. Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells. FEBS Lett 536 (2003) 173-179
52. Nanzer A.M., Khalaf S., Mozid A.M., Fowkes R.C., Patel M.V., Burrin J.M., Grossman A.B., and Korbonits M. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol 151 (2004) 233-240
53. Kim M.S., Yoon C.Y., Jang P.G., Park Y.J., Shin C.S., Park H.S., Ryu J.W., Pak Y.K., Park J.Y., Lee K.U., Kim S.Y., Lee H.K., Kim Y.B., and Park K.S. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol 18 (2004) 2291-2301
54. Navarrete Santos A., Ramin N., Tonack S., and Fischer B. Cell lineage-specific signaling of insulin and insulin-like growth factor I in rabbit blastocysts. Endocrinology 149 (2008) 515-524
55. Fuentes L.Q., Reyes C.E., Sarmiento J.M., Villanueva C.I., Figueroa C.D., Navarro J., and Gonzalez C.B. Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways. Cell Signal 20 (2008) 1642-1650
56. Terashima M., Mitani T., Hosokawa Y., Nariai Y., Imada K., Kageyama E., and Tanigawa Y. Suppressive effect of taurine on platelet-derived growth factor (PDGF) BB-induced c-fos and c-jun mRNA expressions through extracellular signal-regulated kinase (ERK) in mesenchymal cell lines. J Nutr Sci Vitaminol (Tokyo) 49 (2003) 187-194