The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2

European Journal of Heart Failure

Volumn 10, Issue 1, 2008, Pages 39-46

  d'Anglemont de Tassigny, Alexandra ^a,b,c   Berdeaux, Alain ^a,b,c,d   Souktani, Rachid ^b   Henry, Patrick ^e   Ghaleh, Bijan ^a,b,c,d  

^a INSERM   (France)

^b FACULTÉ DE MÉDECINE   (France)

^c ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^d HENRI MONDOR HOSPITAL   (France)

^e HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Apoptosis; Cardiomyocyte; Contractility; Doxorubicin; Volume sensitive chloride channels

Indexed keywords

(2 CYCLOPENTYL 6,7 DICHLORO 2 METHYL 1 OXO 5 INDANYLOXY)ACETIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CASPASE 3; CHLORIDE CHANNEL BLOCKING AGENT; DOXORUBICIN; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARDIOMYOPATHY; CELL ISOLATION; CELL PROTECTION; CELL VOLUME; CHLORIDE CURRENT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; MALE; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CARDIOMYOPATHIES; CHLORIDE CHANNELS; DOXORUBICIN; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOLATES; HEART; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS;

EID: 37549027147     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejheart.2007.11.002     Document Type: Article

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