Effect of Astragalus and Astragalus polysaccharide on antimicrobial peptides PR-39 and protegrin-1 gene expression in pigs

Turkish Journal of Veterinary and Animal Sciences

Volumn 30, Issue 3, 2006, Pages 325-330

  Tu, Youjin ^a   Xu, Chunlan ^a   Wang, Yizhen ^a   Yao, Guojia ^a   Shan, Tizhong ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Antimicrobial peptide; Astragalus; Pigs; PR 39; Protegrin 1

Indexed keywords

ANIMALIA; SUS SCROFA;

EID: 33746765667     PISSN: 13000128     EISSN: 13000128     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Boman, H.G.: Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol., 1995; 13: 61-92.
2. Nicholas, P., Mor, A.: Peptides as weapons against microorganisms in the chemical defense system of vertebrates. Annu. Rev. Microbiol., 1995; 49: 277-304.
3. Boman, H.G.: Gene-encoded peptide antibiotics and the concept of innate immunity: an update review. Scand. J. Immunol., 1998; 48: 15-25.
4. Lehrer, R.I., Ganz, T.: Antimicrobial peptides in mammalian and insect host defense. Curr. Opin. Immunol., 1999; 11: 23-27.
5. Zanetti, M., Gennaro, R., Romeo, D.: Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett., 1995; 374: 1-5.
6. Agerberth, B., Lee, J.Y., Bergman, T., Carlquist, M., Boman, H.G., Mutt, V., Tornvall, H.: Amino acid sequence of PR-39: isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides. Eur. J. Biochem. 1991; 202: 849-854.
7. Gudmundsson, G.H., Magnusson, K.P., Chowdhary, B.P., Johansson, M., Andersson, L., Boman, H.G.: Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39. Proc. Natl. Acad. Sci. USA, 1995; 92: 7085-7089.
8. Storici, P., Zanetti, M.: cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39. Biochem. Biophys. Res. Commun., 1993; 196: 1058-1065.
9. Zhang, G., Ross, C.R., Blecha, F.: Porcine antimicrobial peptides: new prospects for ancient molecules of host defense. Vet. Res., 2000; 31: 277-296.
10. Zhao, C.Q., Ganz, T., Lehrer, R.I.: Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39. FEBS Lett., 1995; 376: 130-134.
11. Zhao, C., Liu, L., Lehrer, R.I.: Identification of a new member of the protegrin-1 family by cDNA cloning. FEBS Lett., 1994; 346: 285-288.
12. Harwig, S.S., Kokryakov, V.N., Swiderek, K.M., Aleshina, G.M., Zhao, C., Lehrer, R.I.: Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes. FEBS Lett., 1995; 362: 65-69.
13. Storici, P., Scocchi, M., Tossi, A., Gennaro, R., Zanetti, M.: Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA. FEBS Lett., 1994; 337: 303-307.
14. Zanetti, M., Litteri, L., Gennaro, R., Horstmann, H., Romeo, D.: Bactenecins, defense polypeptides of bovine neutrophils, are generated from precursor molecules stored in the large granules. J. Cell Biol., 1990; 111: 1363-1371.
15. Panyutich, A., Shi, J., Boutz, P.L., Zhao, C., Ganz, T.: Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins. Infect. Immun. 1997; 65: 978-985.
16. Gudmundsson, G.H., Agerberth, B., Odeberg, J., Bergman, T., Olsson, B., Salcedo, R.: The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur. J. Biochem., 1996; 238: 325-332.
17. Wu, H., Zhang, G.L., Minton, J.E., Ross C.R., Blecha, F.: Regulation of cathelicidin gene expression: induction by lipopolysaccharide, interleukin-6, retinoic acid, and Salmonella enterica Serovar Typhimurium infection. Infect. Immun., 2000; 68: 5552-5558.
18. Lee, K.Y., Jeon, Y.J.: Macrophage activation by polysaccharide isolated from Astragalus membranaceus. Int. Immunopharmacol., 2005; 5: 1225-1233.
19. Bosi, P., Gremokolini, C., Trevisi, P.: Dietary regulations of the intestinal barrier function at weaning. Asian-Aust. J. Anim. Sci., 2003; 16: 596-608.
20. Wu, H., Zhang, G.L., Ross C.R., Blecha, F.: Cathelicidin gene expression in porcine tissues: roles in ontogeny and tissue specificity. Infect. Immun., 1999; 67: 439-442.
21. Wang, Y.Z., Xu, Z.R., Lin, W.X., Huang, H.Q., Wang, Z.Q.: Developmental gene expression of antimicrobial peptide PR-39 and effect of zinc oxide on gene regulation of PR-39 in piglets. Asian-Aust. J. Anim. Sci., 2004; 17: 1635-1640.
22. Shimizu, N., Tomoda, M., Kanari. M., Gonda, R.: An acidic polysaccharide having activity on the recticuloendothelial system from the root of Astragalus mongholicus. Chem. Pharm. Bull., 1991; 39: 2969-2972.
23. Bedir, E., Pugh, N., Calis, I., Pasco, D.S., Khan, I.A.: Immunostimulatory effects of cycloartane-type triterpene glycosides from Astragalus species. Biol. Pharm. Bull., 2000; 23: 834-837.
24. McKenna, D.J., Hughes, K., Jones, K.: Astragalus. Altern. Ther. Health Med., 2002; 8: 34-40.
25. Cui, R., He, J., Wang, B., Zhang, F., Chen, G.Y., Yin, S., Shen, H.: Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemother. Pharmacol., 2003; 51: 75-80.
26. Li, C.M., Gai, G.S., He, X.H., Xing, D.M.: Application of powder technology in Chinese herbal medicine (in Chinese). Chin. Powder Technol., 2004; 35: 16-18.
27. Xu, L.J., Lu, F.E., Zou, X.: A study of the solubilization of Rhizoma coptidis powdered to micrometer particles (in Chinese). Herald of Medicine, 2004; 23: 374-375.
28. Chen, H.L., Zhuo, B.S., Li, D.F., Chang, B.Y., Zhang, J.X.: Effect of Astragaluson lymphocyte proliferation and signal molecules in the spleen of broilers (in Chinese). Chin. J. Vet., 2003; 39: 11-14.
29. Kong, X.F., Hu, Y.L., Rui, R. Wang, D., Li, X.: Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. Int. Immunopharmacol., 2004; 4: 975-982.