Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model

Acta Pharmacologica Sinica

Volumn 28, Issue 12, 2007, Pages 1947-1956

  Mao, Xian Qing ^a   Wu, Yong ^b   Wu, Ke ^a   Liu, Ming ^a   Zhang, Jing Fang ^c   Zou, Feng ^a   Ou Yang, Jing Ping ^a  

^a WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c Jingmen Technical College   (China)

Author keywords

Astragalus membranaceus; Endoplasmic reticulum; Insulin resistance; Polysaccharide; Stress; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; POLYSACCHARIDE; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTRAGALUS MEMBRANACEUS; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FATTY LIVER; FEMALE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN SENSITIVITY; LIVER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ASTRAGALUS PLANT; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; HOMEOSTASIS; INSULIN; LIVER; MICE; MICE, INBRED C57BL; POLYSACCHARIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 36649011202     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00674.x     Document Type: Article

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