Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 3-4, 2009, Pages 207-216

  Quinten, Thomas ^a   Gonnissen, Yves ^a   Adriaens, Els ^a   Beer, Thomas De ^a   Cnudde, Veerle ^a   Masschaele, Bert ^a   Van Hoorebeke, Luc ^a   Siepmann, Juergen ^b   Remon, Jean Paul ^a   Vervaet, Chris ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIV LILLE   (France)

Author keywords

Drug delivery; Ethylcellulose; Injection moulding; L HPC; Low substituted hydroxypropylcellulose; Matrix; Melt extrusion; Metoprolol tartrate; Sustained release; Tablet

Indexed keywords

ETHYL CELLULOSE; HYDROXYPROPYLCELLULOSE; METOPROLOL TARTRATE; SEBACIC ACID DIBUTYL ESTER;

ANISOTROPY; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STRUCTURE; MATRIX TABLET; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TABLET FORMULATION; TABLET HARDNESS; TABLET POROSITY; TEMPERATURE; VISCOMETRY; X RAY POWDER DIFFRACTION;

ADRENERGIC BETA-ANTAGONISTS; ALGORITHMS; CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; METOPROLOL; MODELS, STATISTICAL; SOLUBILITY; TABLETS; TEMPERATURE; VISCOSITY;

EID: 67349157304     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.02.006     Document Type: Article

References (24)

1. Bodea A., and Leucata S.E. Optimization of hydrophilic matrix tablets using a D-optimal design. Int. J. Pharm. 153 (1997) 247-255
2. Breitenbach J., Scrof W., and Neumann J. Confocal Raman-spectroscopy: analytical approach to solid dispersion and mapping of drugs. Pharm. Res. 16 (1999) 1109-1113
3. Crowley M.M., Schroeder B., Fredersdorf A., Obara S., Talarico M., Kucera S., and McGinity J.W. Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion. Int. J. Pharm. 269 (2004) 509-522
4. Crowley M.M., Zhang F., Repka M.A., Thumma S., Upadhye S.B., Battu S.K., McGinity J.W., and Martin C. Pharmaceutical applications of hot-melt extrusion. Part 1. Drug Dev. Ind. Pharm. 33 (2007) 909-926
5. Follonier N., Doelker E., and Cole E.T. Evaluation of hot-melt extrusion as a new technique for the production of polymer-based pellets for sustained-release capsules containing high loadings of freely soluble drugs. Drug Dev. Ind. Pharm. 20 (1994) 1323-1339
6. Forster A., Hempenstall J., Tucker I., and Rades T. Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis. Int. J. Pharm. 226 (2001) 147-161
7. Harper C.A. Modern Plastics Handbook (2000), McGraw-Hill Professional
8. Hicks C.R., and Turner K.V. Fundamental Concepts in the Design of Experiments (1999), Oxford University Press, England
9. Lewis G.A., and Chariot M. Non classical experimental designs in pharmaceutical formulation. Drug Dev. Ind. Pharm. 17 (1991) 1551-1570
10. Quinten T., De Beer T., Vervaet C., and Remon J.P. Evaluation of injection moulding as a pharmaceutical technology to produce matrix tablets. Eur. J. Pharm. Biopharm. 71 (2009) 145-154
11. Repka M.A., Gutta K., Prodduturi S., Munjal M., and Stodghill S.P. Characterization of cellulosic hot-melt extruded films containing lidocaine. Eur. J. Pharm. Biopharm. 59 (2005) 189-196
12. Ritger R.L., and Peppas N.S. A simple equation for disposition of solute release. II. Fickian and anomalous release from swellable devices. J. Control Release 5 (1987) 37-42
13. Rosato D.V. Plastic Processing Data Handbook. 2nd edition (1997), Chapman & Hall, London
14. Rothen-Weinhold A., Besseghir K., Vuaridel E., Sublet E., Oudry N., Kubel F., and Gurny R. Injection-molding versus extrusion as manufacturing technique for the preparation of biodegradable implants. Eur. J. Pharm. Biopharm. 48 (1999) 113-121
15. Schilling S.A., Shah N., Malick A., Waseem A.W., Infeld M.H., and McGinity J.W. Citric acid as a solid-state plasticizer for Eudragit RS PO. J. Pharm. Pharmacol. 11 (2007) 1493-1500
16. Tanaka N., Imai K., Okimoto K., Ueda S., Tokunaga Y., Ohike A., Ibuki R., Higaki K., and Kimura T. Development of novel sustained-release systems, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine. J. Control Release 108 (2005) 386-395
17. Trey S.M., Wicks D.A., and Mididoddi P.K. Delivery of itraconazole from extruded HPC films. Drug Dev. Ind. Pharm. 33 (2007) 727-735
18. Vaz C.M., Van Doeveren P.F.N.M., Dias G.R., Reis R.L., and Cunha A.M. Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding. Macromol. Biosci. 4 (2004) 795-801
19. Verhoeven E., Vervaet C., and Remon J.P. Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation. Eur. J. Pharm. Biopharm. 63 (2006) 320-330
20. Verreck G., Decorte A., Heymans K., Adriaensen J., Cleeren D., Jacobs A., Liu D., Tomasko D., Arien A., Peeters J., Rombaut P., Van den Mooter G., and Brewster M.E. The effect of pressurized carbon dioxide as a temporary plasticizer and foaming agent on the hot stage extrusion process and extrudate properties of solid dispersions of itraconazole with PVP-VA 64. Eur. J. Pharm. Sci. 26 (2005) 349-358
21. Young C.R., Crowley M., Dietzsch C., and McGinity J.W. Physicochemical properties of film-coated melt-extruded pellets. J. Microencapsul. 24 (2007) 57-71
22. Young C.R., Koleng J.J., and McGinity J.W. Production of spherical pellets by a hot-melt extrusion and spheronization process. Int. J. Pharm. 242 (2002) 87-92
23. Zhang Y.E., Tchao R., and Schwartz J.B. Effect of processing methods and heat treatment on the formation of wax matrix tablets for sustained drug release. Pharm. Dev. Technol. 6 (2001) 131-144
24. Zheng W., Cerea M., Sauer D., and McGinity J.W. Properties of theophylline tablets powder-coated with methacrylate ester copolymers. J. Drug Deliv. Sci. Technol. 14 (2004) 319-325