Injection-molding versus extrusion as manufacturing technique for the preparation of biodegradable implants

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 48, Issue 2, 1999, Pages 113-121

  Rothen Weinhold, A ^a,b   Besseghir, K ^c   Vuaridel, E ^b,c   Sublet, E ^b,c   Oudry, N ^a,b   Kubel, F ^a   Gurny, R ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b International Business Park   (France)

^c DEBIOPHARM SA   (Switzerland)

Author keywords

Controlled release; Extrusion; Implant; Injection molding; Polylactic acid; Somatostatin analogue

Indexed keywords

POLYLACTIC ACID; POLYMER; SOMATOSTATIN DERIVATIVE; VAPREOTIDE;

ARTICLE; BIODEGRADATION; CRYSTAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; INTERMETHOD COMPARISON; MOLECULAR WEIGHT; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; SUSTAINED RELEASE PREPARATION; TECHNIQUE; TEMPERATURE;

ABSORBABLE IMPLANTS; BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR WEIGHT; POLYMERS; SOMATOSTATIN; SPECTROPHOTOMETRY, INFRARED; X-RAY DIFFRACTION;

EID: 0032807422     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(99)00034-X     Document Type: Article

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