Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 63, Issue 3, 2006, Pages 320-330

  Verhoeven, E ^a   Vervaet, C ^a   Remon, J P ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Hot melt extrusion; Ibuprofen; Matrix system; Multiple unit dosage form; Sustained release; Xanthan gum

Indexed keywords

ETHYL CELLULOSE; IBUPROFEN; XANTHAN; XANTURAL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFUSION; DISSOLUTION; DOG; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; EROSION; HYDRODYNAMICS; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; IONIC STRENGTH; MALE; MAXIMUM ALLOWABLE CONCENTRATION; NONHUMAN; PARTICLE SIZE; SUSTAINED DRUG RELEASE; SWELLING;

ANIMALS; CELLULOSE; DELAYED-ACTION PREPARATIONS; DOGS; DRUG STABILITY; IBUPROFEN; MALE; OSMOLAR CONCENTRATION; PARTICLE SIZE; POLYSACCHARIDES, BACTERIAL; SOLUBILITY;

EID: 33646835243     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.12.004     Document Type: Article

References (28)

1. Mueller W., Spengler R., Grabowski S., and Sanner A. Feste pharmazeutische Retardforme, European Patent 0 544 144 B1. BASF Aktiengesellschaft (1992)
2. Breitenbach J., Grabowski S., and Rosenberg J. Extrusion von Polymer-Wirkstoff-Gemischen zur Herstellung von Arzneiformen. Spektrum der Wissenschaft (1995) 18-20
3. Breitenbach J. Melt extrusion: from process to drug delivery technology. Eur. J. Pharm. Biopharm. 54 2 (2002) 107-117
4. McGinity J.W., Koleng J.J., Repka M.A., and Zhang F. Hot-melt extrusion technology. In: Swarbrick J., and Boylan J.C. (Eds). Encyclopedia of Pharmaceutical Technology vol. 19 (2001), Marcel Dekker, New York 203-226
5. Follonier N., Doelker E., and Cole E.T. Evaluation of hot-melt extrusion as a new technique for the production of polymer based pellets for sustained release capsules containing high loadings of freely soluble drugs. Drug Dev. Ind. Pharm. 20 8 (1994) 1323-1339
6. Follonier N., Doelker E., and Cole E.T. Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained release pellets prepared using polymeric materials. J. Control Release 36 (1995) 243-250
7. De Brabander C., Vervaet C., and Remon J.P. Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion. J. Control Release 89 2 (2003) 235-247
8. Van Den Abeele W.M., De Brabander C., Vervaet C., Remon J.P., and Van Bortel L.M. Bioavailability of ibuprofen from hot-melt extruded mini-matrices. Br. J. Clin. Pharmacol. 57 3 (2004) 366-367
9. De Brabander C., Vervaet C., Van Bortel L., and Remon J.P. Bioavailability of ibuprofen from hot-melt extruded mini-matrices. Int. J. Pharm. 271 1-2 (2004) 77-84
10. Dhopeshwarkar V., and Zatz J.L. Evaluation of xanthan gum in the preparation of sustained release matrix tablets. Drug Dev. Ind. Pharm. 19 9 (1993) 999-1017
11. Talukdur M.M., Michoel A., Rombaut P., and Kinget R. Comparative study on xanthan gum and hydroxypropyl methylcellulose as matrices for controlled drug delivery. I. Compaction and in vitro drug release behaviour. Int. J. Pharm. 129 (1996) 233-241
12. Talukdur M.M., and Kinget R. Comparative study on xanthan gum and hydropropyl methylcellulose as matrices for controlled-release drug delivery. II. Drug diffusion in hydrated matrices. Int. J. Pharm. 151 (1997) 99-107
13. Talukdur M.M., Vinckier I., Moldenaers P., and Kinget R. Rheological characterisation of xanthan gum and hydroxypropyl methylcellulose with respect to controlled-release drug delivery. J. Pharm. Sci. 85 5 (1996) 537-540
14. Talukdur M.M., and Kinget R. Swelling and drug release behaviour of xanthan gum matrix tablets. Int. J. Pharm. 120 (1995) 63-72
15. Ritger P.L., and Peppas N.A. A simple equation for description of solute release: II. Fickian and anomalous release from swellable devices. J. Control. Release 5 (1987) 37-42
16. U.S. Pharmacopeia 27 & National Formulary 22, The United States Pharmacopeial Convention, Rockville, MD, USA, 2004.
17. Meier J., Nuesch E., and Schmidt R. Pharmacokinetic criteria for the evaluation of retard formulations. Eur. J. Clin. Pharmacol. 7 6 (1974) 429-432
18. Steinijans V.W. Pharmacokinetic characterization of controlled-release formulations. Eur. J. Drug Metab. Pharmacokinet. 15 (1990) 173-181
19. De Brabander C., Van den Mooter G., Vervaet C., and Remon J.P. Characterisation of ibuprofen as a non-traditional plasticizer of ethyl cellulose. J. Pharm. Sci. 91 7 (2002) 1678-1685
20. Talukdar M.M., and Plaizier-Vercammen J. Evaluation of xanthan gum as a hydrophilic matrix for controlled-release dosage form preparations. Drug Dev. Ind. Pharm. 19 9 (1993) 1037-1046
21. Fu Lu M., Woodward L., and Borodkin S. Xanthan gum and alginate based controlled release theophylline formulations. Drug Dev. Ind. Pharm. 17 14 (1991) 1987-2004
22. Cox P.J., Khan K.A., Munday D.L., and Sujja-areevath J. Development and evaluation of a multiple-unit oral sustained release dosage form for S(+)-ibuprofen: preparation and release kinetics. Int. J. Pharm. 193 (1999) 73-84
23. Billa N., Yuen K., Khader M.A.A., and Omar A. Gamma-scintigraphic study of the gastrointestinal transit and in vivo dissolution of a controlled release diclofenac sodium formulation in xanthan gum matrices. Int. J. Pharm. 201 (2000) 109-120
24. Lindner W.D., and Lippold B.C. Drug release from hydrocolloid embeddings with high or low susceptibility to hydrodynamic stress. Pharm. Res. 12 (1995) 1781-1785
25. Callet F., Milas M., and Rinaudo M. Influence of acetyl and pyruvate contents on rheological properties of xanthan in dilute solution. Int. J. Biol. Macromol. 9 (1987) 291-293
26. Johnson J.L., Holiney J., and Williams M.D. Influence of ionic strength on matrix integrity and drug release from hydroxypropyl cellulose compacts. Int. J. Pharm. 90 (1993) 151-159
27. Ingani H.M., and Moes A.J. Utilisation de la gomme xanthane dans la formation des matrices hydrophiles. STP Pharm. 4 (1988) 188-195
28. Peppas N.A. Analysis of Fickian and Non-Fickian drug release from polymers. Pharm. Acta Helv. 60 4 (1985) 110-111