The effect of pressurized carbon dioxide as a temporary plasticizer and foaming agent on the hot stage extrusion process and extrudate properties of solid dispersions of itraconazole with PVP-VA 64

European Journal of Pharmaceutical Sciences

Volumn 26, Issue 3-4, 2005, Pages 349-358

  Verreck, Geert ^a   Decorte, Annelies ^a   Heymans, Koen ^a   Adriaensen, Jef ^a   Cleeren, Dirk ^a   Jacobs, Adri ^a   Liu, Dehua ^b   Tomasko, David ^b   Arien, Albertina ^a   Peeters, Jef ^a   Rombaut, Patrick ^c   Van Den Mooter, Guy ^c   Brewster, Marcus E ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Ohio State University   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Carbon dioxide; Hot stage extrusion; Itraconazole; Pressurized gas; Solid dispersion; Supercritical

Indexed keywords

CARBON DIOXIDE; FOAMING AGENT; ITRACONAZOLE; PLASTICIZER; POLYMER; POLYVINYLPYRROLIDONE CO VINYL ACETATE 64; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; DISPERSION; DISSOLUTION; DRUG MANUFACTURE; HOT STAGE EXTRUSION PROCESS; MORPHOLOGY; PHYSICAL CHEMISTRY; POROSITY; PRESSURE; PRIORITY JOURNAL; TECHNIQUE; TEMPERATURE; WETTABILITY;

ACRYLATES; CARBON DIOXIDE; ITRACONAZOLE; MICROSCOPY; PLASTICIZERS; PYRROLIDINES; PYRROLIDINONES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; VINYL COMPOUNDS;

EID: 24644486062     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.07.006     Document Type: Article

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