Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion

International Journal of Pharmaceutics

Volumn 269, Issue 2, 2004, Pages 509-522

  Crowley, Michael M ^a   Schroeder, Britta ^b   Fredersdorf, Anke ^b   Obara, Sakae ^c   Talarico, Mark ^d   Kucera, Shawn ^a   McGinity, James W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c SHIN ETSU CHEMICAL CO LTD   (Japan)

^d Micromeritics Instrumental Ltd   (United States)

Author keywords

Ethyl cellulose; Free volume; Guaifenesin; Higuchi diffusion model; Hot melt extrusion; Matrix tablets; Mercury porosimetry; Percolation; Porosity; Sustained release; Tortuosity

Indexed keywords

ETHYL CELLULOSE; GUAIFENESIN; HELIUM;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DIFFUSION; DRUG SOLUBILITY; DRUG STABILITY; EXCIPIENT COMPATIBILITY; MEASUREMENT; PHARMACEUTICAL ENGINEERING; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION; TABLET FORMULATION; THERMOSTABILITY; TIMED DRUG RELEASE;

EID: 0347990425     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.09.037     Document Type: Article

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