Production of spherical pellets by a hot-melt extrusion and spheronization process

International Journal of Pharmaceutics

Volumn 242, Issue 1-2, 2002, Pages 87-92

  Young, Christopher R ^a   Koleng, John J ^a   McGinity, James W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

EUDRAGIT Preparation 4135 F; Hot melt extrusion; Spheronization; Theophylline

Indexed keywords

EUDRAGIT; MACROGOL 8000; MICROCRYSTALLINE CELLULOSE; THEOPHYLLINE;

ARTICLE; CONTROLLED DRUG RELEASE; DISSOLUTION; PELLET EXTRUSION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPHERONIZATION; SURFACE PROPERTY; TEMPERATURE;

BRONCHODILATOR AGENTS; DELAYED-ACTION PREPARATIONS; DIFFERENTIAL THERMAL ANALYSIS; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; METHACRYLATES; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; POWDERS; SOLUBILITY; THEOPHYLLINE; TIME FACTORS;

EID: 0037151506     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00152-7     Document Type: Article

References (11)

1. Hot-melt extrusion of acrylic films
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5. Extrusion and spheronization in the development of oral controlled-release dosage forms
6. Diffusion-controlled matrix systems
7. Hot-melt extrusion technology
8. Physical-mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films
9. Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot-melt extrusion
10. Free volume and coatings formulator
11. Properties of sustained release tablets prepared by hot-melt extrusion