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Volumn 19, Issue 4, 2009, Pages 229-235

T antigen transgenic mouse models

Author keywords

Large T antigen; Model system; Mutant analysis; SV40; Transgenic

Indexed keywords

PROTEIN P107; PROTEIN P130; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; VIRUS LARGE T ANTIGEN; VIRUS SMALL T ANTIGEN; VIRUS T ANTIGEN;

EID: 67349156691     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2009.02.002     Document Type: Review
Times cited : (35)

References (66)
  • 1
    • 0022965278 scopus 로고
    • Germ-line transformation of mice
    • Palmiter R.D., and Brinster R.L. Germ-line transformation of mice. Annu Rev Genet 20 (1986) 465-499
    • (1986) Annu Rev Genet , vol.20 , pp. 465-499
    • Palmiter, R.D.1    Brinster, R.L.2
  • 2
    • 0021183267 scopus 로고
    • Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors
    • Brinster R.L., Chen H.Y., Messing A., van Dyke T., Levine A.J., and Palmiter R.D. Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37 2 (1984) 367-379
    • (1984) Cell , vol.37 , Issue.2 , pp. 367-379
    • Brinster, R.L.1    Chen, H.Y.2    Messing, A.3    van Dyke, T.4    Levine, A.J.5    Palmiter, R.D.6
  • 3
    • 0022361679 scopus 로고
    • SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice
    • Palmiter R.D., Chen H.Y., Messing A., and Brinster R.L. SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice. Nature 316 6027 (1985) 457-460
    • (1985) Nature , vol.316 , Issue.6027 , pp. 457-460
    • Palmiter, R.D.1    Chen, H.Y.2    Messing, A.3    Brinster, R.L.4
  • 4
    • 27944459717 scopus 로고    scopus 로고
    • SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation
    • Ahuja D., Saenz-Robles M.T., and Pipas J.M. SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation. Oncogene 24 52 (2005) 7729-7745
    • (2005) Oncogene , vol.24 , Issue.52 , pp. 7729-7745
    • Ahuja, D.1    Saenz-Robles, M.T.2    Pipas, J.M.3
  • 5
    • 0035956239 scopus 로고    scopus 로고
    • Transforming functions of Simian Virus 40
    • Saenz-Robles M.T., Sullivan C.S., and Pipas J.M. Transforming functions of Simian Virus 40. Oncogene 20 54 (2001) 7899-7907
    • (2001) Oncogene , vol.20 , Issue.54 , pp. 7899-7907
    • Saenz-Robles, M.T.1    Sullivan, C.S.2    Pipas, J.M.3
  • 6
    • 0035100475 scopus 로고    scopus 로고
    • Cellular transformation by SV40 large T antigen: interaction with host proteins
    • Ali S.H., and DeCaprio J.A. Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 11 1 (2001) 15-23
    • (2001) Semin Cancer Biol , vol.11 , Issue.1 , pp. 15-23
    • Ali, S.H.1    DeCaprio, J.A.2
  • 7
    • 33748250439 scopus 로고    scopus 로고
    • Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor
    • Lilyestrom W., Klein M.G., Zhang R., Joachimiak A., and Chen X.S. Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor. Genes Dev 20 17 (2006) 2373-2382
    • (2006) Genes Dev , vol.20 , Issue.17 , pp. 2373-2382
    • Lilyestrom, W.1    Klein, M.G.2    Zhang, R.3    Joachimiak, A.4    Chen, X.S.5
  • 8
    • 0031746554 scopus 로고    scopus 로고
    • Polyomavirus T antigens: molecular chaperones for multiprotein complexes
    • Brodsky J.L., and Pipas J.M. Polyomavirus T antigens: molecular chaperones for multiprotein complexes. J Virol 72 7 (1998) 5329-5334
    • (1998) J Virol , vol.72 , Issue.7 , pp. 5329-5334
    • Brodsky, J.L.1    Pipas, J.M.2
  • 9
    • 0036286620 scopus 로고    scopus 로고
    • T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis
    • Sullivan C.S., and Pipas J.M. T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis. Microbiol Mol Biol Rev 66 2 (2002) 179-202
    • (2002) Microbiol Mol Biol Rev , vol.66 , Issue.2 , pp. 179-202
    • Sullivan, C.S.1    Pipas, J.M.2
  • 10
    • 0035882105 scopus 로고    scopus 로고
    • The virus-chaperone connection
    • Sullivan C.S., and Pipas J.M. The virus-chaperone connection. Virology 287 1 (2001) 1-8
    • (2001) Virology , vol.287 , Issue.1 , pp. 1-8
    • Sullivan, C.S.1    Pipas, J.M.2
  • 11
    • 1542317755 scopus 로고    scopus 로고
    • Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation
    • Ali S.H., Kasper J.S., Arai T., and DeCaprio J.A. Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation. J Virol 78 6 (2004) 2749-2757
    • (2004) J Virol , vol.78 , Issue.6 , pp. 2749-2757
    • Ali, S.H.1    Kasper, J.S.2    Arai, T.3    DeCaprio, J.A.4
  • 12
    • 0026576333 scopus 로고
    • Simian virus 40 large T antigen stably complexes with a 185-kilodalton host protein
    • Kohrman D.C., and Imperiale M.J. Simian virus 40 large T antigen stably complexes with a 185-kilodalton host protein. J Virol 66 3 (1992) 1752-1760
    • (1992) J Virol , vol.66 , Issue.3 , pp. 1752-1760
    • Kohrman, D.C.1    Imperiale, M.J.2
  • 13
    • 0034603002 scopus 로고    scopus 로고
    • Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm
    • Tsai S.C., Pasumarthi K.B., Pajak L., Franklin M., Patton B., Wang H., et al. Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm. J Biol Chem 275 5 (2000) 3239-3246
    • (2000) J Biol Chem , vol.275 , Issue.5 , pp. 3239-3246
    • Tsai, S.C.1    Pasumarthi, K.B.2    Pajak, L.3    Franklin, M.4    Patton, B.5    Wang, H.6
  • 14
    • 10744222730 scopus 로고    scopus 로고
    • Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1
    • Cotsiki M., Lock R.L., Cheng Y., Williams G.L., Zhao J., Perera D., et al. Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A 101 4 (2004) 947-952
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.4 , pp. 947-952
    • Cotsiki, M.1    Lock, R.L.2    Cheng, Y.3    Williams, G.L.4    Zhao, J.5    Perera, D.6
  • 16
    • 0031060151 scopus 로고    scopus 로고
    • p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen
    • Lill N.L., Tevethia M.J., Eckner R., Livingston D.M., and Modjtahedi N. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. J Virol 71 1 (1997) 129-137
    • (1997) J Virol , vol.71 , Issue.1 , pp. 129-137
    • Lill, N.L.1    Tevethia, M.J.2    Eckner, R.3    Livingston, D.M.4    Modjtahedi, N.5
  • 17
    • 3242683268 scopus 로고    scopus 로고
    • p53 targets simian virus 40 large T antigen for acetylation by CBP
    • Poulin D.L., Kung A.L., and DeCaprio J.A. p53 targets simian virus 40 large T antigen for acetylation by CBP. J Virol 78 15 (2004) 8245-8253
    • (2004) J Virol , vol.78 , Issue.15 , pp. 8245-8253
    • Poulin, D.L.1    Kung, A.L.2    DeCaprio, J.A.3
  • 18
    • 0036118368 scopus 로고    scopus 로고
    • Enumeration of the simian virus 40 early region elements necessary for human cell transformation
    • Hahn W.C., Dessain S.K., Brooks M.W., King J.E., Elenbaas B., Sabatini D.M., et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 22 7 (2002) 2111-2123
    • (2002) Mol Cell Biol , vol.22 , Issue.7 , pp. 2111-2123
    • Hahn, W.C.1    Dessain, S.K.2    Brooks, M.W.3    King, J.E.4    Elenbaas, B.5    Sabatini, D.M.6
  • 19
    • 23444435456 scopus 로고
    • Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation
    • Mungre S., Enderle K., Turk B., Porras A., Wu Y.Q., Mumby M.C., et al. Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation. J Virol 68 3 (1994) 1675-1681
    • (1994) J Virol , vol.68 , Issue.3 , pp. 1675-1681
    • Mungre, S.1    Enderle, K.2    Turk, B.3    Porras, A.4    Wu, Y.Q.5    Mumby, M.C.6
  • 20
    • 0026578113 scopus 로고
    • T-antigen mutant activities in vivo: roles of p53 and pRB binding in tumorigenesis of the choroid plexus
    • Chen J., Tobin G.J., Pipas J.M., and Van Dyke T. T-antigen mutant activities in vivo: roles of p53 and pRB binding in tumorigenesis of the choroid plexus. Oncogene 7 6 (1992) 1167-1175
    • (1992) Oncogene , vol.7 , Issue.6 , pp. 1167-1175
    • Chen, J.1    Tobin, G.J.2    Pipas, J.M.3    Van Dyke, T.4
  • 21
    • 0026039802 scopus 로고
    • Uniform cell-autonomous tumorigenesis of the choroid plexus by papovavirus large T antigens
    • Chen J.D., and Van Dyke T. Uniform cell-autonomous tumorigenesis of the choroid plexus by papovavirus large T antigens. Mol Cell Biol 11 12 (1991) 5968-5976
    • (1991) Mol Cell Biol , vol.11 , Issue.12 , pp. 5968-5976
    • Chen, J.D.1    Van Dyke, T.2
  • 22
    • 0028226679 scopus 로고
    • Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen
    • Sáenz Robles M.T., Symonds H., Chen J., and Van Dyke T. Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol 14 4 (1994) 2686-2698
    • (1994) Mol Cell Biol , vol.14 , Issue.4 , pp. 2686-2698
    • Sáenz Robles, M.T.1    Symonds, H.2    Chen, J.3    Van Dyke, T.4
  • 23
    • 0028169994 scopus 로고
    • p53-dependent apoptosis suppresses tumor growth and progression in vivo
    • Symonds H., Krall L., Remington L., Sáenz-Robles M., Lowe S., Jacks T., et al. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78 4 (1994) 703-711
    • (1994) Cell , vol.78 , Issue.4 , pp. 703-711
    • Symonds, H.1    Krall, L.2    Remington, L.3    Sáenz-Robles, M.4    Lowe, S.5    Jacks, T.6
  • 24
    • 0032160407 scopus 로고    scopus 로고
    • Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
    • Pan H., Yin C., Dyson N.J., Harlow E., Yamasaki L., and Van Dyke T. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell 2 3 (1998) 283-292
    • (1998) Mol Cell , vol.2 , Issue.3 , pp. 283-292
    • Pan, H.1    Yin, C.2    Dyson, N.J.3    Harlow, E.4    Yamasaki, L.5    Van Dyke, T.6
  • 25
    • 0032949352 scopus 로고    scopus 로고
    • Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction
    • Liao M.J., Yin C., Barlow C., Wynshaw-Boris A., and van Dyke T. Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction. Mol Cell Biol 19 4 (1999) 3095-3102
    • (1999) Mol Cell Biol , vol.19 , Issue.4 , pp. 3095-3102
    • Liao, M.J.1    Yin, C.2    Barlow, C.3    Wynshaw-Boris, A.4    van Dyke, T.5
  • 26
    • 0036490954 scopus 로고    scopus 로고
    • Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
    • Xiao A., Wu H., Pandolfi P.P., Louis D.N., and Van Dyke T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1 2 (2002) 157-168
    • (2002) Cancer Cell , vol.1 , Issue.2 , pp. 157-168
    • Xiao, A.1    Wu, H.2    Pandolfi, P.P.3    Louis, D.N.4    Van Dyke, T.5
  • 27
    • 0026658127 scopus 로고
    • Glucagon gene 5′-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice
    • Lee Y.C., Asa S.L., and Drucker D.J. Glucagon gene 5′-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice. J Biol Chem 267 15 (1992) 10705-10708
    • (1992) J Biol Chem , vol.267 , Issue.15 , pp. 10705-10708
    • Lee, Y.C.1    Asa, S.L.2    Drucker, D.J.3
  • 28
    • 0034320192 scopus 로고    scopus 로고
    • Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice
    • Ratineau C., Ronco A., and Leiter A.B. Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Gastroenterology 119 5 (2000) 1305-1311
    • (2000) Gastroenterology , vol.119 , Issue.5 , pp. 1305-1311
    • Ratineau, C.1    Ronco, A.2    Leiter, A.B.3
  • 29
    • 0030006158 scopus 로고    scopus 로고
    • Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice
    • Upchurch B.H., Fung B.P., Rindi G., Ronco A., and Leiter A.B. Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice. Development 122 4 (1996) 1157-1163
    • (1996) Development , vol.122 , Issue.4 , pp. 1157-1163
    • Upchurch, B.H.1    Fung, B.P.2    Rindi, G.3    Ronco, A.4    Leiter, A.B.5
  • 30
    • 0030863618 scopus 로고    scopus 로고
    • Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice
    • Garabedian E.M., Roberts L.J., McNevin M.S., and Gordon J.I. Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J Biol Chem 272 38 (1997) 23729-23740
    • (1997) J Biol Chem , vol.272 , Issue.38 , pp. 23729-23740
    • Garabedian, E.M.1    Roberts, L.J.2    McNevin, M.S.3    Gordon, J.I.4
  • 31
    • 0035870260 scopus 로고    scopus 로고
    • Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi
    • Gum Jr. J.R., Hicks J.W., Gillespie A.M., Rius J.L., Treseler P.A., Kogan S.C., et al. Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi. Cancer Res 61 8 (2001) 3472-3479
    • (2001) Cancer Res , vol.61 , Issue.8 , pp. 3472-3479
    • Gum Jr., J.R.1    Hicks, J.W.2    Gillespie, A.M.3    Rius, J.L.4    Treseler, P.A.5    Kogan, S.C.6
  • 32
    • 0033580850 scopus 로고    scopus 로고
    • Targeted expression of SV40 large T-antigen to visceral smooth muscle induces proliferation of contractile smooth muscle cells and results in megacolon
    • Herring B.P., Hoggatt A.M., Smith A.F., and Gallagher P.J. Targeted expression of SV40 large T-antigen to visceral smooth muscle induces proliferation of contractile smooth muscle cells and results in megacolon. J Biol Chem 274 25 (1999) 17725-17732
    • (1999) J Biol Chem , vol.274 , Issue.25 , pp. 17725-17732
    • Herring, B.P.1    Hoggatt, A.M.2    Smith, A.F.3    Gallagher, P.J.4
  • 33
    • 0027363255 scopus 로고
    • Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia
    • Kim S.H., Roth K.A., Moser A.R., and Gordon J.I. Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia. J Cell Biol 123 4 (1993) 877-893
    • (1993) J Cell Biol , vol.123 , Issue.4 , pp. 877-893
    • Kim, S.H.1    Roth, K.A.2    Moser, A.R.3    Gordon, J.I.4
  • 34
    • 0028277921 scopus 로고
    • Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice
    • Kim S.H., Roth K.A., Coopersmith C.M., Pipas J.M., and Gordon J.I. Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice. Proc Natl Acad Sci U S A 91 15 (1994) 6914-6918
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.15 , pp. 6914-6918
    • Kim, S.H.1    Roth, K.A.2    Coopersmith, C.M.3    Pipas, J.M.4    Gordon, J.I.5
  • 35
    • 0026636048 scopus 로고
    • Expression of SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle but has no apparent effect on cellular differentiation programs and does not cause neoplastic transformation
    • Hauft S.M., Kim S.H., Schmidt G.H., Pease S., Rees S., Harris S., et al. Expression of SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle but has no apparent effect on cellular differentiation programs and does not cause neoplastic transformation. J Cell Biol 117 4 (1992) 825-839
    • (1992) J Cell Biol , vol.117 , Issue.4 , pp. 825-839
    • Hauft, S.M.1    Kim, S.H.2    Schmidt, G.H.3    Pease, S.4    Rees, S.5    Harris, S.6
  • 36
    • 19944395197 scopus 로고    scopus 로고
    • Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53
    • Markovics J.A., Carroll P.A., Robles M.T., Pope H., Coopersmith C.M., and Pipas J.M. Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53. J Virol 79 12 (2005) 7492-7502
    • (2005) J Virol , vol.79 , Issue.12 , pp. 7492-7502
    • Markovics, J.A.1    Carroll, P.A.2    Robles, M.T.3    Pope, H.4    Coopersmith, C.M.5    Pipas, J.M.6
  • 37
    • 0030852842 scopus 로고    scopus 로고
    • Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle
    • Coopersmith C.M., Chandrasekaran C., McNevin M.S., and Gordon J.I. Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle. J Cell Biol 138 1 (1997) 167-179
    • (1997) J Cell Biol , vol.138 , Issue.1 , pp. 167-179
    • Coopersmith, C.M.1    Chandrasekaran, C.2    McNevin, M.S.3    Gordon, J.I.4
  • 38
    • 36348937368 scopus 로고    scopus 로고
    • Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2
    • Saenz-Robles M.T., Markovics J.A., Chong J.L., Opavsky R., Whitehead R.H., Leone G., et al. Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2. J Virol 81 23 (2007) 13191-13199
    • (2007) J Virol , vol.81 , Issue.23 , pp. 13191-13199
    • Saenz-Robles, M.T.1    Markovics, J.A.2    Chong, J.L.3    Opavsky, R.4    Whitehead, R.H.5    Leone, G.6
  • 39
    • 0029854273 scopus 로고    scopus 로고
    • Use of normal and transgenic mice to examine the relationship between terminal differentiation of intestinal epithelial cells and accumulation of their cell cycle regulators
    • Chandrasekaran C., Coopersmith C.M., and Gordon J.I. Use of normal and transgenic mice to examine the relationship between terminal differentiation of intestinal epithelial cells and accumulation of their cell cycle regulators. J Biol Chem 271 45 (1996) 28414-28421
    • (1996) J Biol Chem , vol.271 , Issue.45 , pp. 28414-28421
    • Chandrasekaran, C.1    Coopersmith, C.M.2    Gordon, J.I.3
  • 40
    • 34548191457 scopus 로고    scopus 로고
    • Enterocyte proliferation and intestinal hyperplasia induced by simian virus 40 T antigen require a functional J domain
    • Rathi A.V., Saenz Robles M.T., and Pipas J.M. Enterocyte proliferation and intestinal hyperplasia induced by simian virus 40 T antigen require a functional J domain. J Virol 81 17 (2007) 9481-9489
    • (2007) J Virol , vol.81 , Issue.17 , pp. 9481-9489
    • Rathi, A.V.1    Saenz Robles, M.T.2    Pipas, J.M.3
  • 41
    • 33644862798 scopus 로고    scopus 로고
    • The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium
    • Haigis K., Sage J., Glickman J., Shafer S., and Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J Biol Chem 281 1 (2006) 638-647
    • (2006) J Biol Chem , vol.281 , Issue.1 , pp. 638-647
    • Haigis, K.1    Sage, J.2    Glickman, J.3    Shafer, S.4    Jacks, T.5
  • 42
    • 0030842829 scopus 로고    scopus 로고
    • gamma-Ray-induced apoptosis in transgenic mice with proliferative abnormalities in their intestinal epithelium: re-entry of villus enterocytes into the cell cycle does not affect their radioresistance but enhances the radiosensitivity of the crypt by inducing p53
    • Coopersmith C.M., and Gordon J.I. gamma-Ray-induced apoptosis in transgenic mice with proliferative abnormalities in their intestinal epithelium: re-entry of villus enterocytes into the cell cycle does not affect their radioresistance but enhances the radiosensitivity of the crypt by inducing p53. Oncogene 15 2 (1997) 131-141
    • (1997) Oncogene , vol.15 , Issue.2 , pp. 131-141
    • Coopersmith, C.M.1    Gordon, J.I.2
  • 43
    • 0034601420 scopus 로고    scopus 로고
    • Different impact of p53 and p21 on the radiation response of mouse tissues
    • Komarova E.A., Christov K., Faerman A.I., and Gudkov A.V. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene 19 33 (2000) 3791-3798
    • (2000) Oncogene , vol.19 , Issue.33 , pp. 3791-3798
    • Komarova, E.A.1    Christov, K.2    Faerman, A.I.3    Gudkov, A.V.4
  • 46
    • 2342443437 scopus 로고    scopus 로고
    • Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb
    • Chen Q., Liang D., Fromm L.D., and Overbeek P.A. Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb. J Biol Chem 279 17 (2004) 17667-17673
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 17667-17673
    • Chen, Q.1    Liang, D.2    Fromm, L.D.3    Overbeek, P.A.4
  • 47
    • 0028071541 scopus 로고
    • The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice
    • Fromm L., Shawlot W., Gunning K., Butel J.S., and Overbeek P.A. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol Cell Biol 14 10 (1994) 6743-6754
    • (1994) Mol Cell Biol , vol.14 , Issue.10 , pp. 6743-6754
    • Fromm, L.1    Shawlot, W.2    Gunning, K.3    Butel, J.S.4    Overbeek, P.A.5
  • 48
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser S.D., Williams B.O., Jacks T., and DePinho R.A. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371 6492 (1994) 72-74
    • (1994) Nature , vol.371 , Issue.6492 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 49
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
    • Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315 6015 (1985) 115-122
    • (1985) Nature , vol.315 , Issue.6015 , pp. 115-122
    • Hanahan, D.1
  • 50
    • 27144556188 scopus 로고    scopus 로고
    • Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis
    • Casanovas O., Hager J.H., Chun M.G., and Hanahan D. Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. Oncogene 24 44 (2005) 6597-6604
    • (2005) Oncogene , vol.24 , Issue.44 , pp. 6597-6604
    • Casanovas, O.1    Hager, J.H.2    Chun, M.G.3    Hanahan, D.4
  • 51
    • 0033015334 scopus 로고    scopus 로고
    • An unexpected role for p53 in augmenting SV40 large T antigen-mediated tumorigenesis
    • Herzig M., Novatchkova M., and Christofori G. An unexpected role for p53 in augmenting SV40 large T antigen-mediated tumorigenesis. Biol Chem 380 2 (1999) 203-211
    • (1999) Biol Chem , vol.380 , Issue.2 , pp. 203-211
    • Herzig, M.1    Novatchkova, M.2    Christofori, G.3
  • 52
    • 0028356419 scopus 로고
    • A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
    • Christofori G., Naik P., and Hanahan D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 369 6479 (1994) 414-418
    • (1994) Nature , vol.369 , Issue.6479 , pp. 414-418
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 53
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
    • Lopez T., and Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1 4 (2002) 339-353
    • (2002) Cancer Cell , vol.1 , Issue.4 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 54
    • 0023247255 scopus 로고
    • Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice
    • Ornitz D.M., Hammer R.E., Messing A., Palmiter R.D., and Brinster R.L. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science 238 4824 (1987) 188-193
    • (1987) Science , vol.238 , Issue.4824 , pp. 188-193
    • Ornitz, D.M.1    Hammer, R.E.2    Messing, A.3    Palmiter, R.D.4    Brinster, R.L.5
  • 55
    • 0025148310 scopus 로고
    • Hyperplasia and tumors of the islets of Langerhans in mice bearing an elastase I-SV40 T-antigen fusion gene
    • Bell Jr. R.H., Memoli V.A., and Longnecker D.S. Hyperplasia and tumors of the islets of Langerhans in mice bearing an elastase I-SV40 T-antigen fusion gene. Carcinogenesis 11 8 (1990) 1393-1398
    • (1990) Carcinogenesis , vol.11 , Issue.8 , pp. 1393-1398
    • Bell Jr., R.H.1    Memoli, V.A.2    Longnecker, D.S.3
  • 56
    • 0025964473 scopus 로고
    • Transgenic mice carrying a murine amylase 2.2/SV40 T antigen fusion gene develop pancreatic acinar cell and stomach carcinomas
    • Ceci J.D., Kovatch R.M., Swing D.A., Jones J.M., Snow C.M., Rosenberg M.P., et al. Transgenic mice carrying a murine amylase 2.2/SV40 T antigen fusion gene develop pancreatic acinar cell and stomach carcinomas. Oncogene 6 2 (1991) 323-332
    • (1991) Oncogene , vol.6 , Issue.2 , pp. 323-332
    • Ceci, J.D.1    Kovatch, R.M.2    Swing, D.A.3    Jones, J.M.4    Snow, C.M.5    Rosenberg, M.P.6
  • 57
    • 0029143354 scopus 로고
    • Inactivation of p53 and the development of tetraploidy in the elastase-SV40 T antigen transgenic mouse pancreas
    • Ramel S., Sanchez C.A., Schimke M.K., Neshat K., Cross S.M., Raskind W.H., et al. Inactivation of p53 and the development of tetraploidy in the elastase-SV40 T antigen transgenic mouse pancreas. Pancreas 11 3 (1995) 213-222
    • (1995) Pancreas , vol.11 , Issue.3 , pp. 213-222
    • Ramel, S.1    Sanchez, C.A.2    Schimke, M.K.3    Neshat, K.4    Cross, S.M.5    Raskind, W.H.6
  • 58
    • 0030843485 scopus 로고    scopus 로고
    • A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice
    • Tevethia M.J., Bonneau R.H., Griffith J.W., and Mylin L. A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice. J Virol 71 11 (1997) 8157-8166
    • (1997) J Virol , vol.71 , Issue.11 , pp. 8157-8166
    • Tevethia, M.J.1    Bonneau, R.H.2    Griffith, J.W.3    Mylin, L.4
  • 59
    • 0032504956 scopus 로고    scopus 로고
    • The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice
    • Bennoun M., Grimber G., Couton D., Seye A., Molina T., Briand P., et al. The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice. Oncogene 17 10 (1998) 1253-1259
    • (1998) Oncogene , vol.17 , Issue.10 , pp. 1253-1259
    • Bennoun, M.1    Grimber, G.2    Couton, D.3    Seye, A.4    Molina, T.5    Briand, P.6
  • 60
    • 0027269675 scopus 로고
    • Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant
    • Symonds H.S., McCarthy S.A., Chen J., Pipas J.M., and Van Dyke T. Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant. Mol Cell Biol 13 6 (1993) 3255-3265
    • (1993) Mol Cell Biol , vol.13 , Issue.6 , pp. 3255-3265
    • Symonds, H.S.1    McCarthy, S.A.2    Chen, J.3    Pipas, J.M.4    Van Dyke, T.5
  • 61
    • 0033842443 scopus 로고    scopus 로고
    • The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism
    • Sullivan C.S., Cantalupo P., and Pipas J.M. The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism. Mol Cell Biol 20 17 (2000) 6233-6243
    • (2000) Mol Cell Biol , vol.20 , Issue.17 , pp. 6233-6243
    • Sullivan, C.S.1    Cantalupo, P.2    Pipas, J.M.3
  • 62
    • 0030794278 scopus 로고    scopus 로고
    • Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
    • Stubdal H., Zalvide J., Campbell K.S., Schweitzer C., Roberts T.M., and DeCaprio J.A. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol 17 9 (1997) 4979-4990
    • (1997) Mol Cell Biol , vol.17 , Issue.9 , pp. 4979-4990
    • Stubdal, H.1    Zalvide, J.2    Campbell, K.S.3    Schweitzer, C.4    Roberts, T.M.5    DeCaprio, J.A.6
  • 63
    • 0027074996 scopus 로고
    • Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter
    • al-Ubaidi M.R., Font R.L., Quiambao A.B., Keener M.J., Liou G.I., Overbeek P.A., et al. Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. J Cell Biol 119 6 (1992) 1681-1687
    • (1992) J Cell Biol , vol.119 , Issue.6 , pp. 1681-1687
    • al-Ubaidi, M.R.1    Font, R.L.2    Quiambao, A.B.3    Keener, M.J.4    Liou, G.I.5    Overbeek, P.A.6
  • 64
    • 0027384597 scopus 로고
    • Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development
    • Pichel J.G., Lakso M., and Westphal H. Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development. Oncogene 8 12 (1993) 3333-3342
    • (1993) Oncogene , vol.8 , Issue.12 , pp. 3333-3342
    • Pichel, J.G.1    Lakso, M.2    Westphal, H.3
  • 65
    • 0036133649 scopus 로고    scopus 로고
    • p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo
    • Tolbert D., Lu X., Yin C., Tantama M., and Van Dyke T. p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo. Mol Cell Biol 22 1 (2002) 370-377
    • (2002) Mol Cell Biol , vol.22 , Issue.1 , pp. 370-377
    • Tolbert, D.1    Lu, X.2    Yin, C.3    Tantama, M.4    Van Dyke, T.5
  • 66
    • 61649094675 scopus 로고    scopus 로고
    • Cantalupo Sáenz Robles MT, Rathi AV, Beerman RW, Patterson WH, Whitehead RH, et al. Cell-type specific regulation of gene expression by simian virus 40 T antigens. Virology. 2009 Feb 6. [Epub ahead of print]. PMID: 19201438.
    • Cantalupo PG, Sáenz Robles MT, Rathi AV, Beerman RW, Patterson WH, Whitehead RH, et al. Cell-type specific regulation of gene expression by simian virus 40 T antigens. Virology. 2009 Feb 6. [Epub ahead of print]. PMID: 19201438.


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