Comparable dose-dependent inhibition of AP-7 sensitive strychnine- induced allodynia and paw pinch-induced nociception by mexiletine in the rat

Pain

Volumn 72, Issue 3, 1997, Pages 299-308

  Khandwala, Hemal ^a   Hodge, Elizabeth ^a   Loomis, Christopher W ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Allodynia; AP 7; Mexiletine; Rat; Spinal; Strychnine

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; ALLYL ISOTHIOCYANATE; MEXILETINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; STRYCHNINE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROENCEPHALOGRAPHY; HEART RATE; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MECHANICAL STIMULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; WITHDRAWAL REFLEX;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOT; HYPERESTHESIA; MALE; MEXILETINE; NOCICEPTORS; PAIN; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; STRYCHNINE;

EID: 0030863922     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(97)00021-3     Document Type: Article

References (54)

1. Aanonsen, L.M. and Wilcox, G.L., Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists, J. Pharm. Exp. Ther., 243 (1987) 9-19.
2. Beyer, C., Banas, C., Gomora, P. and Komisaruk, B.R., Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids, Pharmacol. Biochem. Behav., 29 (1988) 73-78.
3. Beyer, C., Roberts, L.A. and Komisaruk, B.R., Hyperalgesia induced by altered glycinergic activity at the spinal cord, Life Sci., 37 (1985) 875-882.
4. Campbell, N.J., Raja, N.S., Meyer, A.R. and Mackinnon, E.S., Myelinated afferents signal hyperalgesia associated with nerve injury, Pain, 32 (1988) 89-94.
5. Chabal, C., Jacobson, L., Mariano, A., Chaney, E. and Britell, W.C., The use of oral mexiletine for the treatment of pain after peripheral nerve injury, Anesthesiology, 76 (1992) 513-517.
6. Chabal, C., Russell, L.C. and Burchiel, K.J., The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas, Pain, 38 (1989) 333-338.
7. Chaplan, S.R., Bach, F.W., Shafer, S.L. and Yaksh, T.L., Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats, Anesthesiology, 83 (1995) 775-785.
8. Cline, M.A., Ochoa, J. and Torebjörk, H.E., Chronic hyperalgesia and skin warming caused by sensitized C nociceptors, Brain, 112 (1989) 621-647.
9. Curtis, D.R., Duggan, A.W. and Johnston, G.A.R., The specificity of strychnine as a glycine antagonist in the mammalian spinal cord, Exp. Brain Res., 12 (1971) 547-565.
10. Curtis, D.R., Hösli, L. and Johnston, G.A.R., A pharmacological study of the depression of spinal neurones by glycine and related amino acids, Exp. Brain Res., 6 (1968) 1-18.
11. Dejgard, A., Petersen, P. and Kastrup, J., Mexiletine for treatment of chronic painful diabetic neuropathy, Lancet, 29 (1988) 9-11.
12. DeJong, R.H., Robles, R. and Corbin, R.W., Central actions of lidocaine; synaptic transmission, Anesthesiology, 30 (1969) 19-23.
13. Devor, M., Wall, P.D. and Catalan, N., Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction, Pain, 48 (1992) 261-268.
14. Dickenson, A.H., Recent advances in the physiology and pharmacology of pain: plasticity and its implications for clinical analgesia, J. Psychopharmacol., 5 (1991) 342-351.
15. Dickenson, A.H. and Sullivan, A.F., Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep dorsal horn neurons following C-fibre stimulation, Neuropharmacology, 26 (1987) 1235-1238.
16. Dohi, S., Kitihata, L.M., Toyooka, H., Ohtani, M., Namiki, A. and Taub, A., An analgesic action of intravenously administered lidocaine on dorsal horn neurons responding to noxious thermal stimulation, Anesthesiology, 51 (1979) 123-126.
17. Duggan, S., Milne, B. and Loomis, C., Use of differential normal pulse voltammetry for the measurement of locus coeruleus catecholaminergic metabolism in an acute anesthetized rodent model of allodynia: effect of mexiletine, J. Neurosci. Methods (1997) in press.
18. Fraser, H.M., Chapman, V. and Dickenson, A.H., Spinal local anesthetic action on afferent evoked responses and wind-up of nociceptive neurones in the rat spinal cord; combination with morphine produces marked potentiation of antinociception, Pain, 49 (1992) 33-41.
19. Game, C.J.A. and Lodge, D., The pharmacology of inhibition of dorsal horn neurons by impulses in myelinated cutaneous afferents in the cat, Exp. Brain Res., 23 (1975) 75-84.
20. Hao, J.-X., Xu, X.-J., Aldskogius, H., Seiger, Å. and Weisenfeld-Hallin, Z., The excitatory amino acid receptor antagonist MK-801 prevents the hypersensitivity induced by spinal cord ischemia in the rat, Exp. Neurol., 113 (1991) 182-191.
21. Hegarty, A. and Portenoy, R.K., Pharmacotherapy of neuropathic pain, Semin. Neurol., 14 (1994) 213-224.
22. Igwemezie, L.N., Beatch, G.N., McErlane, K.M. and Walker, M.J.A., Mexiletine's antifibrillatory actions are limited by the occurrence of convulsions in conscious animals, Eur. J. Pharmacol., 210 (1992) 271-277.
23. Igwemezie, L., Beatch, G.N., Walker, M.J.A. and McErlane, K.M., Tissue distribution of mexiletine enantiomers in rats, Xenobiotica, 21 (1991) 1153-1158.
24. Jessell, T.M., Yoshioka, K. and Jahr, C.E., Amino acid receptor-mediated transmission at primary afferent synapses in rat spinal cord, J. Exp. Biol., 124 (1986) 239-258.
25. Meyer, R.A., Campbell, J.N. and Raja, S.N., Peripheral neural mechanisms of cutaneous hyperalgesia. In: H.L. Fields, R. Dubner and P. Cervero (Eds.), Advances in Pain Research and Therapy, Vol. 9, Raven Press, New York, 1985, pp. 53-71.
26. Milne, B., Duggan, S., Jhamandas, K. and Loomis, C.W., Innocuous hair deflection evokes a nociceptive-like activation of catechol oxidation in the rat locus coeruleus following intrathecal strychnine: a biochemical index of allodynia using in vivo voltammetry, Brain Res., 718 (1996) 198-202.
27. Morris, R., Responses of spinal dorsal horn neurones evoked by myelinated primary afferent stimulation are blocked by excitatory amino acid antagonists acting at kainate/quisqualate receptors, Neurosci. Lett., 105 (1989) 79-85.
28. Nagy, I. and Woolf, C.J., Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N-methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations: implications for the development of novel centrally acting analgesics, Pain, 64 (1996) 59-70.
29. Nässtrom, J., Karlsson, U. and Post, C., Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice, Eur. J. Pharmacol., 212 (1992) 21-29.
30. Onaka, M., Minami, T., Nishihara, I. and Ito, S., Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice, Anesthesiology, 84 (1996) 1215-1222.
31. Price, D.D., Bennett, J.G. and Rafii, A., Psychophysiological observations on patients with neuropathic pain relieved by a sympathetic block, Pain, 36 (1989) 273-288.
32. Salt, T.E. and Hill, R.G., Neurotransmitter candidates of somatosensory primary afferent fibres, Neuroscience, 10 (1983) 1083-1103.
33. Sherman, S.E. and Loomis, C.W., Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat, Pain, 56 (1994) 17-29.
34. Sherman, S.E. and Loomis, C.W., Strychnine-dependent allodynia in the urethane-anesthetized rat is segmentally distributed and prevented by intrathecal glycine and betaine, Can. J. Physiol. Pharmacol., 73 (1995) 1698-1705.
35. Sherman, S.E. and Loomis, C.W., Strychnine-sensitive modulation is selective for non-noxious somatosensory input in the spinal cord, Pain, 66 (1996) 321-330.
36. Sherman, S.E., Luo, L. and Dostrovsky, D.O., Spinal strychnine alters receptive fields and sensory modalities of rat thalamic neurons, Proceedings of the 8th World Congress on Pain, Vancouver, Canada, IASP Press, 1996, p. 245.
37. Sorkin, L.S. and Puig, S., Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a μ-opiate receptor agonist, Pain, 68 (1996) 283-292.
38. Sosnowski, M. and Yaksh, T.L., Role of spinal adenosine receptors in modulating the hyperesthesia produced by spinal glycine receptor antagonism, Anesth. Analg., 69 (1989) 587-592.
39. Tallarida, R.J. and Murray, R.B., Manual of Pharmacologic Calculations, Springer-Verlag, New York, 1987, pp. 10-30.
40. Tanelian, D.L. and MacIver, M.B., Analgesic concentrations of lidocaine suppress tonic A-delta and C fiber discharges produced by acute injury, Anesthesiology, 74 (1991) 934-936.
41. Todd, A.J., An electron microscope study of glycine-like immunoreactivity in lamina I-III of the spinal dorsal horn of the rat, Neuroscience, 39 (1990) 387-394.
42. Todd, .J. and Sullivan, A.C., Light microscopic study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat, J. Comp. Neurol., 296 (1990) 496-505.
43. Treede, R.-D., Raja, S.N., Davis, K.D., Meyer, R.A. and Campbell, J.N., Evidence that alpha-adrenergic receptors mediate sympathetically maintained pain. In: M.R. Bond, J.E. Charlton and C.J. Woolf (Eds.), Proceedings of the VIth World Congress on Pain, Elsevier, Amsterdam, 1991, pp. 377-382.
44. Urban, L., Thompson, S.W.N. and Dray, A., Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters, Trends Neurosci., 17 (1994) 432-438.
45. Wall, P.D. and Devor, M., Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats, Pain, 17 (1983) 321-339.
46. Wilcockson, W.S., Chung, J.M., Hori, Y., Lee, K.H. and Willis, W.D., Effects of iontophoretically released peptides on primate spinothalamic tract cells, J. Neurosci., 4 (1984) 741-750.
47. Wilcox, G.L., Kitto, K.F. and Loomis, C.W., Spinal neuronal responses to innocuous stimulation 'wind-up' in the presence of i.t. strychnine, Soc. Neurosci., 208.10 (1996), 511.
48. Woolf, C.J. and Thompson, S.W.N., The induction and maintenance of central sensitization is dependent on NMDA receptor activation: implication for the treatment of post-injury pain hypersensitivity states, Pain, 44 (1991) 293-299.
49. Woolf, C.J. and Wall, P.D., The relative effectiveness of C-primary affer-ent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat, J. Neurosci., 6 (1986) 1433-1442.
50. Woolf, C.J. and Wiesenfeld-Hallin, Z., The systemic administration of local anesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord, Pain, 23 (1985) 361-374.
51. Xu, X.-J., Hao, J.-X., Seiger, Å., Arner, S., Lindblom, U. and Wiesenfeld-Hallin, Z., Systemic mexiletine relieves chronic allodynia-like symptoms in rats with ischemic spinal cord injury, Anesth. Analg., 74 (1992) 649-652.
52. Xu, X.-J., Hao, J.-X., Seiger, Å. and Weisenfeld-Hallin, Z., Systemic excitatory amino acid receptor antagonists of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor and of the N-methyl-D-aspartate receptor relieve mechanical hypersensitivity after transient spinal cord ischemia in rats, J. Pharmacol. Exp. Ther., 267 (1993) 140-144.
53. Yaksh, T.L., Behavioral and autonomic correlates of tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists, Pain, 37 (1989) 111-123.
54. Yaksh, T.L. and Rudy, T.A., Chronic catheterization of the spinal subarachnoid space, Physiol. Behav., 17 (1976) 1031-1036.