In vivo function of VDR in gene expression-VDR knock-out mice

Journal of Steroid Biochemistry and Molecular Biology

Volumn 69, Issue 1-6, 1999, Pages 247-251

  Kato, Shigeaki ^a,b   Takeyama, Ken Ichi ^a   Kitanaka, Sachiko ^a   Murayama, Akiko ^a   Sekine, Keisuke ^a   Yoshizawa, Tatsuya ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; VITAMIN D; VITAMIN D RECEPTOR;

CONFERENCE PAPER; FAMILIAL DISEASE; GENE EXPRESSION; GROWTH RETARDATION; HUMAN; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE MUTANT; NONHUMAN; OSSIFICATION; PHENOTYPE; RECEPTOR INTRINSIC ACTIVITY; RICKETS; SEQUENCE HOMOLOGY; TRANSACTIVATION; VITAMIN BLOOD LEVEL;

ANIMALS; BONE DEVELOPMENT; CLONING, MOLECULAR; GENE EXPRESSION REGULATION; GENE TARGETING; HUMANS; MICE; MICE, KNOCKOUT; RECEPTORS, CALCITRIOL; RICKETS; STEROID HYDROXYLASES; VITAMIN D;

EID: 0032977450     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(99)00042-4     Document Type: Conference Paper

References (23)

1. Bouillon R., Okamura W.H., Norman A.W. Structure-function relationships in the vitamin D endocrine system. End. Rev. 16:1995;200-257.
2. Studzinski G.P., McLane J.A., Uskokovic M.R. Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases. Crit. Rev. Eukar. Gene Exp. 3:1993;279-312.
3. Darwish H., DeLuca H.F. Vitamin D-regulated gene expression. Cric. Rev. Eukar. Gene Exp. 3:1993;89-116.
4. Mangelsdorf D.J., Evans R.M. The RXR heterodimers and orphan receptors. Cell. 83:1995;841-850.
5. Ebihara K., Masuhiro Y., Kitamoto T., Suzawa M., Uematsu Y., Yoshizawa T., Ono T., Harada H., Hasegawa T., Masushige S., Kato S. Intron retention generates α novel isoform of the murine vitamin D receptor that acts in α dominant negative way on the vitamin D signaling pathway. Mol. Cell. Biol. 16:1996;3393-3400.
6. Reichel H., Koeffler H.P., Norman A.W. The role of the vitamin D endocrine system in health and disease. N. Engl. J. Med. 320:1989;980-991.
7. Fraser D.R. Regulation of the metabolism of vitamin D. Physiol. Rev. 60:1980;551-613.
8. Yoshizawa T., Handa Y., Uemasu Y., Takeda S., Sekine K., Yoshihara Y., Kawakami T., Arioka K., Sato H., Uchiyama Y., Masushige S., Fukamizu A., Matsumoto T., Kato S. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nature Gen. 16:1997;391-396.
9. Lian J.B., Coutts M., Canalis E. Studies of hormonal regulation of osteocalcin synthesis in cultured fetal rat calvariae. J. Biol. Chem. 260:1985;8706-8710.
10. Li Y.C., Pirro A.E., Amling M., et al. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc. Natl. Acad. Sci. USA. 94:1997;9831-9835.
11. Marx S.J., Liberman U.A., Eil C., et al. Hereditary resistance to 1,25-dihydroxyvitamin D. Rec. Prog. Hor. Res. 40:1984;589-620.
12. Hughes M.R., Malloy P.J., Kieback D.G., et al. Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science. 242:1988;1702-1705.
13. Fraser D.R. Regulation of the vitamin D metabolism. Physiol. Reviews. 60:1980;556-613.
14. Noda M., Vogel R.L., Craig A.M., et al. Identification of α DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc. Natl. Acad. Sci. USA. 87:1990;9995-9999.
15. Stein G.S., Lian J.B. Molecular mechanisms mediating proliferation/differentiation inter-relationship during progressive development of the osteoblast phenotype. Endocr. Rev. 14:1993;424-442.
16. Rigby W.F.C. The immunobiology of vitamin D. Immunology Today. 9:1988;54-58.
17. Takeyama K., Kitanaka S., Sato T., Kobori M., Yanagisawa J., Kato S. 25-Hydroxyvitamin D3 1α-hydroxylase and vitamin D synthesis. Science. 277:1997;1827-1830.
18. Kitanaka S., Takeyama K., Murayama A., Sato T., Okumura K., Nogami M., Hasegawa Y., Niimi H., Yanagisawa J., Tanaka T., Kato S. Inactivating mutations in the 25-hydroxyvitamin D3 1α-hydroxylase gene in patients with pseudovitamin D-deficient rickets. N. Engl. J. Med. 338:1998;653-661.
19. Henry H.L., Midgett R.J., Norman A.W. Studies on calciferol metabolism: Regulation of 25-hydroxyvitamin D3-1α-hydroxylase, in vivo. J. Biol. Chem. 249:1974;7584-7592.
20. Henry H.L. Regulation of the hydroxylation of 25-hydroxvitamin D3 in vivo and in primary cultures of chick kidney cells. J. Biol. Chem. 254:1979;2722-2729.
21. Malloy P.J., Hochberg Z., Tiosano D., Pike J.W., Hughes M.R., Feldman D. The molecular basis of hereditary 1,25-dihydroxyvitamin D3 resistant rickets in seven related families. J. Clin. Invest. 86:1990;2071-2079.
22. Labuda M., Morgan K., Glorieux F.H. Mapping autosomal recessive vitamin D dependency type 1 to chromosomal 12q14 by linkage abalysis. Am. J. Hum. Genet. 47:1990;28-36.
23. Ohyama Y., Ozono K., Uchida M., Shinki T., Kato S., Suda T., Yamamoto O., Noshiro M., Kato Y. Identification of α vitamin D-responsive element in the 5′-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene. J. Biol. Chem. 265:1994;10,545-10,550.